Nimbolide enhances the antitumor effect of docetaxel via abrogation of the NF-κB signaling pathway in prostate cancer preclinical models

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

(2022) Sepideh Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chemopreventive Potential of Dietary Nanonutraceuticals for Prostate Cancer: An Extensive Review

(2022) Hitesh Chopra et al.   Frontiers in Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Paradoxical functions of long noncoding RNAs in modulating STAT3 signaling pathway in hepatocellular carcinoma

(2021) Chakrabhavi Dhananjaya Mohan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?

(2021) Sepideh Mirzaei et al.   CANCER LETTERS

Diosgenin attenuates tumor growth and metastasis in transgenic prostate cancer mouse model by negatively regulating both NF-κB/STAT3 signaling cascades

(2021) Sakshi Sikka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway

(2021) Loukik Arora et al.   Cancers

Targeting STAT3 signaling pathway in cancer by agents derived from Mother Nature

(2020) Chakrabhavi Dhananjaya Mohan et al.   SEMINARS IN CANCER BIOLOGY

Small Molecule NF-κB Pathway Inhibitors in Clinic

(2020) Venkataramanan Ramadass et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NF-κB signaling promotes castration-resistant prostate cancer initiation and progression

(2020) Shayna E. Thomas-Jardin et al.   PHARMACOLOGY & THERAPEUTICS

Pharmacological significance of the non-canonical NF-κB pathway in tumorigenesis

(2020) Dhakshayini Morgan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Formononetin Regulates Multiple Oncogenic Signaling Cascades and Enhances Sensitivity to Bortezomib in a Multiple Myeloma Mouse Model

(2019) Chulwon Kim et al.   Biomolecules

Impact of taxanes on androgen receptor signaling

(2018) Yan Dong et al.   ASIAN JOURNAL OF ANDROLOGY

Formononetin-induced oxidative stress abrogates the activation of STAT3/5 signaling axis and suppresses the tumor growth in multiple myeloma preclinical model

(2018) Chulwon Kim et al.   CANCER LETTERS

Recent Advances in Prostate Cancer Treatment and Drug Discovery

(2018) Ekaterina Nevedomskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endophytic Fungi—Alternative Sources of Cytotoxic Compounds: A Review

(2018) Fazilath Uzma et al.   Frontiers in Pharmacology

Celastrol Attenuates the Invasion and Migration and Augments the Anticancer Effects of Bortezomib in a Xenograft Mouse Model of Multiple Myeloma

(2018) Muthu K. Shanmugam et al.   Frontiers in Pharmacology

Novel 1,3,4-Oxadiazole Induces Anticancer Activity by Targeting NF-κB in Hepatocellular Carcinoma Cells

(2018) Chakrabhavi Dhananjaya Mohan et al.   Frontiers in Oncology

Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial

(2018) Liselotte M.S. Boevé et al.   EUROPEAN UROLOGY

Oleuropein induces apoptosis via abrogating NF-κB activation cascade in estrogen receptor-negative breast cancer cells

(2018) Lian Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications

(2018) Jens Staal et al.   Cells

Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis

(2018) Muthu K. Shanmugam et al.   Frontiers in Pharmacology

N-Substituted Pyrido-1,4-Oxazin-3-Ones Induce Apoptosis of Hepatocellular Carcinoma Cells by Targeting NF-κB Signaling Pathway

(2018) Chakrabhavi Dhananjaya Mohan et al.   Frontiers in Pharmacology

Dissecting major signaling pathways in prostate cancer development and progression: Mechanisms and novel therapeutic targets

(2017) Senthilmurugan Ramalingam et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Neem ( Azadirachta indica ): An indian traditional panacea with modern molecular basis

(2017) Subash Chandra Gupta et al.   PHYTOMEDICINE

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nimbolide inhibits androgen independent prostate cancer cells survival and proliferation by modulating multiple pro-survival signaling pathways

(2016) P. Raja Singh et al.   BIOMEDICINE & PHARMACOTHERAPY

Survivin: a unique target for tumor therapy

(2016) Himani Garg et al.   Cancer Cell International

Targeting the NF-κB pathway in prostate cancer: a promising therapeutic approach?

(2016) Daniela Verzella et al.   CURRENT DRUG TARGETS

Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles

(2016) Kebballi N. Nandeesh et al.   NEW JOURNAL OF CHEMISTRY

Potential of neem ( Azadirachta indica L.) for prevention and treatment of oncologic diseases

(2016) Shradha M. Patel et al.   SEMINARS IN CANCER BIOLOGY

Capsazepine inhibits JAK/STAT3 signaling, tumor growth, and cell survival in prostate cancer

(2016) Jong Hyun Lee et al.   Oncotarget

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

(2016) Lingzhi Wang et al.   Oncotarget

Metastatic castration-resistant prostate cancer (CRPC): preclinical and clinical evidence for the sequential use of novel therapeutics

(2014) Deborah Mukherji et al.   CANCER AND METASTASIS REVIEWS

Bergamottin, a natural furanocoumarin obtained from grapefruit juice induces chemosensitization and apoptosis through the inhibition of STAT3 signaling pathway in tumor cells

(2014) Sung-Moo Kim et al.   CANCER LETTERS

Development of a Novel Azaspirane That Targets the Janus Kinase-Signal Transducer and Activator of Transcription (STAT) Pathway in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Chakrabhavi Dhananjaya Mohan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Synthetic Biscoumarins Target Tumor Necrosis Factor-α in Hepatocellular Carcinomain Vitroandin Vivo

(2014) Hosadurga Kumar Keerthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression

(2014) R Jin et al.   ONCOGENE

Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms

(2014) Lakshmi Narendra Bodduluru et al.   TOXICOLOGY IN VITRO

Synthesis, biological evaluation and in silico and in vitro mode-of-action analysis of novel dihydropyrimidones targeting PPAR-γ

(2014) Hanumantharayappa Bharathkumar et al.   RSC Advances

X-Linked Inhibitor of Apoptosis Protein – A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer Therapy

(2014) Petra Obexer et al.   Frontiers in Oncology

Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth

(2013) S. Karkare et al.   CLINICAL CANCER RESEARCH

Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment

(2013) S. C. Gupta et al.   CLINICAL CANCER RESEARCH

Simvastatin sensitizes human gastric cancer xenograft in nude mice to capecitabine by suppressing nuclear factor-kappa B-regulated gene products

(2013) Kanjoormana A. Manu et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Novel therapeutic approaches for the treatment of castration-resistant prostate cancer

(2013) Isabel Heidegger et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

First Evidence That  -Tocotrienol Inhibits the Growth of Human Gastric Cancer and Chemosensitizes It to Capecitabine in a Xenograft Mouse Model through the Modulation of NF- B Pathway

(2012) K. A. Manu et al.   CLINICAL CANCER RESEARCH

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Targeting PPARγSignaling Cascade for the Prevention and Treatment of Prostate Cancer

(2012) Sakshi Sikka et al.   PPAR Research

Overcoming docetaxel resistance in prostate cancer: a perspective review

(2012) Clara Hwang   Therapeutic Advances in Medical Oncology

PARP-1 cleavage fragments: signatures of cell-death proteases in neurodegeneration

(2011) Ganta Chaitanya et al.   Cell Communication and Signaling

Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model

(2011) Muthu K. Shanmugam et al.   INTERNATIONAL JOURNAL OF CANCER

Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

(2011) Muthu K. Shanmugam et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Characterisation and manipulation of docetaxel resistant prostate cancer cell lines

(2011) Amanda J O'Neill et al.   Molecular Cancer

Docetaxel-based combination therapy for castration-resistant prostate cancer

(2010) M. D. Galsky et al.   ANNALS OF ONCOLOGY

Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells

(2010) Angeline Wei Ling Chua et al.   BIOCHEMICAL PHARMACOLOGY

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combination of Bevacizumab and Docetaxel in Docetaxel-Pretreated Hormone-Refractory Prostate Cancer: A Phase 2 Study

(2008) Giuseppe Di Lorenzo et al.   EUROPEAN UROLOGY

Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-κB ligand through modulation of NF-κB pathway

(2008) Kwang Seok Ahn et al.   INTERNATIONAL JOURNAL OF CANCER

Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway

(2007) Kwang Seok Ahn et al.   BIOCHEMICAL PHARMACOLOGY