Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis

Risk of oral cancer associated with gutka and other tobacco products: A hospital-based case-control study

(2015) Sandeep Mahapatra et al.   Journal of Cancer Research and Therapeutics

Expression and inactivation of glycogen synthase kinase 3 alpha/ beta and their association with the expression of cyclin D1 and p53 in oral squamous cell carcinoma progression

(2015) Rajakishore Mishra et al.   Molecular Cancer

Pharmacogenomic and molecular docking studies on the cytotoxicity of the natural steroid wortmannin against multidrug-resistant tumor cells

(2015) Victor Kuete et al.   PHYTOMEDICINE

GSK-3 as potential target for therapeutic intervention in cancer

(2015) James A. McCubrey et al.   Oncotarget

Ellagic Acid Inhibits VEGF/VEGFR2, PI3K/Akt and MAPK Signaling Cascades in the Hamster Cheek Pouch Carcinogenesis Model

(2014) Jaganathan Kowshik et al.   Anti-Cancer Agents in Medicinal Chemistry

PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer

(2014) HaiXia Li et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

(2014) AndrewC Hsieh et al.   ASIAN JOURNAL OF ANDROLOGY

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

(2014) Sree Vidya Krishna Rao et al.   Asian Pacific Journal of Cancer Prevention

ERKs in Cancer: Friends or Foes?

(2014) Xavier Deschênes-Simard et al.   CANCER RESEARCH

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Tight regulation between cell survival and programmed cell death in GBM stem-like cells by EGFR/GSK3b/PP2A signaling

(2014) Demirkan B. Gürsel et al.   JOURNAL OF NEURO-ONCOLOGY

β-Catenin in oral cancer: An update on current knowledge

(2014) M.A. González-Moles et al.   ORAL ONCOLOGY

Astaxanthin Inhibits JAK/STAT-3 Signaling to Abrogate Cell Proliferation, Invasion and Angiogenesis in a Hamster Model of Oral Cancer

(2014) J. Kowshik et al.   PLoS One

Differential activity of GSK-3 isoforms regulates NF-κB and TRAIL- or TNFα induced apoptosis in pancreatic cancer cells

(2014) J-S Zhang et al.   Cell Death & Disease

Activator or inhibitor? GSK-3 as a new drug target

(2013) Fumi Takahashi-Yanaga   BIOCHEMICAL PHARMACOLOGY

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

(2013) K. Kavitha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line

(2013) Paulraj Raja Singh et al.   CELL BIOCHEMISTRY AND FUNCTION

Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway

(2013) Xu Sun et al.   CELLULAR SIGNALLING

Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth

(2013) S. Karkare et al.   CLINICAL CANCER RESEARCH

Glycogen synthase kinase-3 beta regulates Snail and β-catenin expression during Fas-induced epithelial–mesenchymal transition in gastrointestinal cancer

(2013) Haoxuan Zheng et al.   EUROPEAN JOURNAL OF CANCER

Growth Inhibition and Apoptosis-Inducing Effects of Cudraflavone B in Human Oral Cancer Cells via MAPK, NF-κB, and SIRT1 Signaling Pathway

(2013) Hwa-Jeong Lee et al.   PLANTA MEDICA

Of Humans and Hamsters: The Hamster Buccal Pouch Carcinogenesis Model as a Paradigm for Oral Oncogenesis and Chemoprevention

(2012) S. Nagini   Anti-Cancer Agents in Medicinal Chemistry

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Regulation of glycogen synthase kinase-3 beta (GSK-3β) by the Akt pathway in gliomas

(2012) Ryan J. Atkins et al.   JOURNAL OF CLINICAL NEUROSCIENCE

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Quercetin suppresses cytochrome P450 mediated ROS generation and NFκB activation to inhibit the development of 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch carcinomas

(2011) Ramamurthi Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

(2011) Suboj Babykutty et al.   MOLECULAR CARCINOGENESIS

Aberrant activation of Wnt/β-catenin signaling pathway contributes to the sequential progression of DMBA-induced HBP carcinomas

(2011) Ramamurthi Vidya Priyadarsini et al.   ORAL ONCOLOGY

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

(2010) R. Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

Glycogen synthase kinase 3 beta: can it be a target for oral cancer

(2010) Rajakishore Mishra   Molecular Cancer

Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

(2010) Steven D. Knight et al.   ACS Medicinal Chemistry Letters

Transcriptional Upregulation of Mitochondrial Uncoupling Protein 2 Protects Against Oxidative Stress-Associated Neurogenic Hypertension

(2009) Samuel H.H. Chan et al.   CIRCULATION RESEARCH

The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis

(2009) Ramamurthi Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis

(2009) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS