DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets

A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility

(2013) Michael C. Bassik et al.   CELL

Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients

(2013) Gerald Schwank et al.   Cell Stem Cell

Kinesin-12 Differentially Affects Spindle Assembly Depending on Its Microtubule Substrate

(2013) Emma G. Sturgill et al.   CURRENT BIOLOGY

EGF-Induced Centrosome Separation Promotes Mitotic Progression and Cell Survival

(2013) Balca R. Mardin et al.   DEVELOPMENTAL CELL

Mitotic Kinesin Eg5 Overcomes Inhibition to the Phase I/II Clinical Candidate SB743921 by an Allosteric Resistance Mechanism

(2013) Sandeep K. Talapatra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The “survivin suppressants” NSC 80467 and YM155 induce a DNA damage response

(2012) Trevor G. Glaros et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Using transcriptome sequencing to identify mechanisms of drug action and resistance

(2012) Sarah A Wacker et al.   Nature Chemical Biology

Cancer drug's survivin suppression called into question

(2012) David Holmes   NATURE MEDICINE

Identification and validation of protein targets of bioactive small molecules

(2011) Denis V. Titov et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The cancer genome

(2009) Michael R. Stratton et al.   NATURE

Next-generation DNA sequencing

(2008) Jay Shendure et al.   NATURE BIOTECHNOLOGY