Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

Correction to: Licarin A induces cell death by activation of autophagy and apoptosis in non-small cell lung cancer cells

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Ginkgolic acid induces interplay between apoptosis and autophagy regulated by ROS generation in colon cancer

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Nimbolide reduces CD44 positive cell population and induces mitochondrial apoptosis in pancreatic cancer cells

(2018) Sandeep Kumar et al.   CANCER LETTERS

Till Death Do Us Part: The Marriage of Autophagy and Apoptosis

(2018) Katrina F. Cooper   Oxidative Medicine and Cellular Longevity

Nimbolide epigenetically regulates autophagy and apoptosis in breast cancer

(2018) Venkatesh Pooladanda et al.   TOXICOLOGY IN VITRO

Nimbolide induces apoptosis in human nasopharyngeal cancer cells

(2017) Su-Yu Chien et al.   ENVIRONMENTAL TOXICOLOGY

Global incidence of oral and oropharynx cancer in patients younger than 45 years versus older patients: A systematic review

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Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

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A novel interplay between HOTAIR and DNA methylation in osteosarcoma cells indicates a new therapeutic strategy

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Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

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Evaluation of Apoptosis and Autophagy Inducing Potential of Berberis aristata, Azadirachta indica, and Their Synergistic Combinations in Parental and Resistant Human Osteosarcoma Cells

(2017) Pracheta Sengupta et al.   Frontiers in Oncology

Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model

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Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways

(2016) Yashi Mi et al.   FREE RADICAL BIOLOGY AND MEDICINE

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(2016) Shradha M. Patel et al.   SEMINARS IN CANCER BIOLOGY

Nimbolide, a neem limonoid inhibits Phosphatidyl Inositol-3 Kinase to activate Glycogen Synthase Kinase-3β in a hamster model of oral oncogenesis

(2016) Josephraj Sophia et al.   Scientific Reports

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

The critical molecular interconnections in regulating apoptosis and autophagy

(2015) Gao-Xiang Zhao et al.   ANNALS OF MEDICINE

Caspase-mediated cleavage of Beclin1 inhibits autophagy and promotes apoptosis induced by S1 in human ovarian cancer SKOV3 cells

(2015) Xiaoning Li et al.   APOPTOSIS

Cancer-type-specific crosstalk between autophagy, necroptosis and apoptosis as a pharmacological target

(2015) Flavia Radogna et al.   BIOCHEMICAL PHARMACOLOGY

Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway

(2015) Feng Wang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma

(2015) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells

(2015) Benoît Marchand et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-mediated crosstalk between autophagy and apoptosis: Mutual adjustment or matter of dominance

(2015) ShrawanKumar Singh et al.   Journal of Cancer Research and Therapeutics

Pterostilbene induce autophagy on human oral cancer cells through modulation of Akt and mitogen-activated protein kinase pathway

(2015) Chung-Po Ko et al.   ORAL ONCOLOGY

Induction of cell cycle arrest, DNA damage, and apoptosis by nimbolide in human renal cell carcinoma cells

(2015) Yi-Hsien Hsieh et al.   TUMOR BIOLOGY

Potential Compounds for Oral Cancer Treatment: Resveratrol, Nimbolide, Lovastatin, Bortezomib, Vorinostat, Berberine, Pterostilbene, Deguelin, Andrographolide, and Colchicine

(2015) Saurabh Bundela et al.   PLoS One

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Natural Products Targeting Autophagy via the PI3K/Akt/mTOR Pathway as Anticancer Agents

(2013) Hui Sun et al.   Anti-Cancer Agents in Medicinal Chemistry

Anti-proliferative and apoptosis inducing effect of nimbolide by altering molecules involved in apoptosis and IGF signalling via PI3K/Akt in prostate cancer (PC-3) cell line

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Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth

(2013) S. Karkare et al.   CLINICAL CANCER RESEARCH

High LC3 expression correlates with poor survival in patients with oral squamous cell carcinoma

(2013) Jen-Yang Tang et al.   HUMAN PATHOLOGY

Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2

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Of Humans and Hamsters: The Hamster Buccal Pouch Carcinogenesis Model as a Paradigm for Oral Oncogenesis and Chemoprevention

(2012) S. Nagini   Anti-Cancer Agents in Medicinal Chemistry

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

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Aberrant activation of Wnt/β-catenin signaling pathway contributes to the sequential progression of DMBA-induced HBP carcinomas

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The Bcl-2-Beclin 1 interaction in (-)-gossypol-induced autophagy versus apoptosis in prostate cancer cells

(2010) Jiqin Lian et al.   Autophagy

The neem limonoids azadirachtin and nimbolide induce cell cycle arrest and mitochondria-mediated apoptosis in human cervical cancer (HeLa) cells

(2010) R. Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

The neem limonoids azadirachtin and nimbolide inhibit hamster cheek pouch carcinogenesis by modulating xenobiotic-metabolizing enzymes, DNA damage, antioxidants, invasion and angiogenesis

(2009) Ramamurthi Vidya Priyadarsini et al.   FREE RADICAL RESEARCH

The neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis

(2009) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

A combination of indol-3-carbinol and genistein synergistically induces apoptosis in human colon cancer HT-29 cells by inhibiting Akt phosphorylation and progression of autophagy

(2009) Yoshitaka Nakamura et al.   Molecular Cancer

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS