Nimbolide attenuates gut dysbiosis and prevents bacterial translocation by improving intestinal barrier integrity and ameliorating inflammation in hepatocellular carcinoma

Profiling of tumour-associated microbiota in human hepatocellular carcinoma

(2021) Seiga Komiyama et al.   Scientific Reports

Nimbolide ameliorates the streptozotocin-induced diabetic retinopathy in rats through the inhibition of TLR4/NF-κB signaling pathway

(2021) Xiangwen Shu et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Epidemiology and surveillance for hepatocellular carcinoma: New trends

(2020) Amit G. Singal et al.   JOURNAL OF HEPATOLOGY

Gut microbiome in HCC – Mechanisms, diagnosis and therapy

(2020) Robert F. Schwabe et al.   JOURNAL OF HEPATOLOGY

Epidemiology of Hepatocellular Carcinoma

(2020) Katherine A. McGlynn et al.   HEPATOLOGY

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

(2020) Xiang Zhang et al.   GUT

Ginkgolide-A attenuates bacterial translocation through activating PXR and improving antimicrobial peptide Reg 3A in experimental cirrhosis

(2020) Sundhar Mohandas et al.   LIFE SCIENCES

Tight Junction Structure and Function Revisited

(2020) Tetsuhisa Otani et al.   TRENDS IN CELL BIOLOGY

Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies

(2020) Ceyhan Ceran Serdar et al.   Biochemia Medica

Nimbolide inhibits tumor growth by restoring hepatic tight junction protein expression and reduced inflammation in an experimental hepatocarcinogenesis

(2020) Amit Kumar Ram et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The Intestinal Microbiota and Colorectal Cancer

(2020) Yiwen Cheng et al.   Frontiers in Immunology

Bacterial translocation and risk of liver cancer in a Finnish cohort

(2019) Baiyu Yang et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Inflammation and Liver Cancer: Molecular Mechanisms and Therapeutic Targets

(2019) Yoon Yang et al.   SEMINARS IN LIVER DISEASE

Nimbolide protects against endotoxin-induced acute respiratory distress syndrome by inhibiting TNF-α mediated NF-κB and HDAC-3 nuclear translocation

(2019) Venkatesh Pooladanda et al.   Cell Death & Disease

Resveratrol attenuates high-fat diet-induced non-alcoholic steatohepatitis by maintaining gut barrier integrity and inhibiting gut inflammation through regulation of the endocannabinoid system

(2019) Mengting Chen et al.   CLINICAL NUTRITION

Effect of protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice

(2019) Shafinaz Abd Gani et al.   PLoS One

Pregnane X receptor activation by its natural ligand Ginkgolide-A improves tight junction proteins expression and attenuates bacterial translocation in cirrhosis

(2019) Sundhar Mohandas et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Increased systemic zonula occludens 1 associated with inflammation and independent biomarker in patients with hepatocellular carcinoma

(2018) Amit Kumar Ram et al.   BMC CANCER

Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in nonalcoholic fatty liver disease

(2018) Francesca Romana Ponziani et al.   HEPATOLOGY

On determining sample size in experiments involving laboratory animals

(2018) Michael FW Festing   LABORATORY ANIMALS

Resveratrol Ameliorates Intestinal Barrier Defects and Inflammation in Colitic Mice and Intestinal Cells

(2018) Yunika Mayangsari et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Nimbolide, a neem limonoid inhibits cytoprotective autophagy to activate apoptosis via modulation of the PI3K/Akt/GSK-3β signalling pathway in oral cancer

(2018) Josephraj Sophia et al.   Cell Death & Disease

Exposure to a Social Stressor Induces Translocation of Commensal Lactobacilli to the Spleen and Priming of the Innate Immune System

(2017) William P. Lafuse et al.   JOURNAL OF IMMUNOLOGY

Prognostic significance of serum procalcitonin in patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoembolization

(2017) Hujia Shen et al.   MEDICINE

Regulation of the intestinal tight junction by natural polyphenols: A mechanistic perspective

(2016) Guan Yang et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Therapeutics Role ofAzadirachta indica(Neem) and Their Active Constituents in Diseases Prevention and Treatment

(2016) Mohammad A. Alzohairy   Evidence-based Complementary and Alternative Medicine

Intracellular, biofilm-inhibitory and membrane-damaging activities of nimbolide isolated from Azadirachta indica A. Juss (Meliaceae) against meticillin-resistant Staphylococcus aureus

(2016) Prodipta Sarkar et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Nimbolide Inhibits Nuclear Factor-КB Pathway in Intestinal Epithelial Cells and Macrophages and Alleviates Experimental Colitis in Mice

(2016) Ji Yeon Seo et al.   PHYTOTHERAPY RESEARCH

Probiotics modulated gut microbiota suppresses hepatocellular carcinoma growth in mice

(2016) Jun Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis

(2015) Jie Yin et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Doxorubicin and curcumin co-delivery by lipid nanoparticles for enhanced treatment of diethylnitrosamine-induced hepatocellular carcinoma in mice

(2015) Xiaojing Zhao et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Methods to determine intestinal permeability and bacterial translocation during liver disease

(2015) Lirui Wang et al.   JOURNAL OF IMMUNOLOGICAL METHODS

20(S)-Ginsenoside Rg3 is a novel inhibitor of autophagy and sensitizes hepatocellular carcinoma to doxorubicin

(2015) Dong-Gun Kim et al.   Oncotarget

Lactobacillus amylovorus Inhibits the TLR4 Inflammatory Signaling Triggered by Enterotoxigenic Escherichia coli via Modulation of the Negative Regulators and Involvement of TLR2 in Intestinal Caco-2 Cells and Pig Explants

(2014) Alberto Finamore et al.   PLoS One

Modulation of Intestinal TLR4-Inflammatory Signaling Pathways by Probiotic Microorganisms: Lessons Learned from Lactobacillus jensenii TL2937

(2014) Julio Villena et al.   Frontiers in Immunology

Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment

(2013) S. C. Gupta et al.   CLINICAL CANCER RESEARCH

Lipopolysaccharide-Induced Toll-Like Receptor 4 Signaling in Cancer Cells Promotes Cell Survival and Proliferation in Hepatocellular Carcinoma

(2013) Lili Wang et al.   DIGESTIVE DISEASES AND SCIENCES

Correlation analysis of preoperative serum alpha-fetoprotein (AFP) level and prognosis of hepatocellular carcinoma (HCC) after hepatectomy

(2013) Wen-jun Ma et al.   World Journal of Surgical Oncology

Lipopolysaccharide Causes an Increase in Intestinal Tight Junction Permeability in Vitro and in Vivo by Inducing Enterocyte Membrane Expression and Localization of TLR-4 and CD14

(2012) Shuhong Guo et al.   AMERICAN JOURNAL OF PATHOLOGY

Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4

(2012) Dianne H. Dapito et al.   CANCER CELL

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Profound impact of gut homeostasis on chemically-induced pro-tumorigenic inflammation and hepatocarcinogenesis in rats

(2012) Hui-Lu Zhang et al.   JOURNAL OF HEPATOLOGY

Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2 and antibacterial peptides

(2012) A L Frantz et al.   Mucosal Immunology

Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway

(2012) P. Elumalai et al.   TOXICOLOGY LETTERS

Endotoxin accumulation prevents carcinogen-induced apoptosis and promotes liver tumorigenesis in rodents

(2010) Le-Xing Yu et al.   HEPATOLOGY

Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cells

(2010) G. Cuevas-Ramos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens

(2009) J G Fox et al.   GUT

Nimbolide a limonoid from Azadirachta indica inhibits proliferation and induces apoptosis of human choriocarcinoma (BeWo) cells

(2008) G. Harish Kumar et al.   INVESTIGATIONAL NEW DRUGS

The Interplay between Entamoeba and Enteropathogenic Bacteria Modulates Epithelial Cell Damage

(2008) José Manuel Galván-Moroyoqui et al.   PLoS Neglected Tropical Diseases