Eras of designer Tregs: Harnessing synthetic biology for immune suppression

Low-dose IL-2 promotes immune regulation in face transplantation: A pilot study

(2023) Naoka Murakami et al.   AMERICAN JOURNAL OF TRANSPLANTATION

TIGIT agonism alleviates costimulation blockade-resistant rejection in a regulatory T cell–dependent manner

(2023) Christina R. Hartigan et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Optimum timing of antithymocyte globulin in relation to adoptive regulatory T cell therapy

(2023) Moritz Muckenhuber et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Enforced gut homing of murine regulatory T cells reduces early graft-versus-host disease severity

(2023) Jemma H. Larson et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

(2023) Mehmet Emrah Selli et al.   BLOOD

Targeting regulatory T cell metabolism in disease: Novel therapeutic opportunities

(2023) Torin Halvorson et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Principles of regulatory T cell function

(2023) Stanislav Dikiy et al.   IMMUNITY

A chemically inducible IL-2 receptor signaling complex allows for effective in vitro and in vivo selection of engineered CD4+ T cells

(2023) Peter J. Cook et al.   MOLECULAR THERAPY

Tonic-signaling chimeric antigen receptors drive human regulatory T cell exhaustion

(2023) Caroline Lamarche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal regulation of peripheral T cell tolerance

(2023) Chrysothemis C. Brown et al.   SCIENCE

Hypoimmune anti-CD19 chimeric antigen receptor T cells provide lasting tumor control in fully immunocompetent allogeneic humanized mice

(2023) Xiaomeng Hu et al.   Nature Communications

Co-expression of Foxp3 and Helios facilitates the identification of human T regulatory cells in health and disease

(2023) Lyra Morina et al.   Frontiers in Immunology

Targeting of chimeric antigen receptor T cell metabolism to improve therapeutic outcomes

(2023) Priyanka Maridhi Nanjireddy et al.   Frontiers in Immunology

Allogeneic chimeric antigen receptor-T cells with CRISPR-disrupted programmed death-1 checkpoint exhibit enhanced functional fitness

(2023) Elaine Lau et al.   CYTOTHERAPY

Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application

(2023) Pierre Henschel et al.   JOURNAL OF AUTOIMMUNITY

Anti‐HLA‐A2‐CAR Tregs prolong vascularized mouse heterotopic heart allograft survival

(2022) Johanna C. Wagner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Towards gene therapy for IPEX syndrome

(2022) Simon Borna et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation

(2022) Lidia Yshii et al.   NATURE IMMUNOLOGY

Dynamic transcriptional activity and chromatin remodeling of regulatory T cells after varied duration of interleukin-2 receptor signaling

(2022) Alejandro Moro et al.   NATURE IMMUNOLOGY

Study Design: Human Leukocyte Antigen Class I Molecule A∗02-Chimeric Antigen Receptor Regulatory T Cells in Renal Transplantation

(2022) Katharina Schreeb et al.   Kidney International Reports

Preclinical assessment of antigen-specific chimeric antigen receptor regulatory T cells for use in solid organ transplantation

(2022) Emma Proics et al.   GENE THERAPY

mTORC1 Inhibition Protects Human Regulatory T Cells From Granzyme-B-Induced Apoptosis

(2022) Siawosh K. Eskandari et al.   Frontiers in Immunology

FOXP3 exon 2 controls T reg stability and autoimmunity

(2022) Jianguang Du et al.   Science Immunology

Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses

(2022) Sara Bolivar-Wagers et al.   JCI Insight

IL ‐2 receptor engineering enhances regulatory T cell function suppressed by calcineurin inhibitor

(2022) Toshihito Hirai et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Forced Fox-P3 expression can improve the safety and antigen-specific function of engineered regulatory T cells

(2022) Jenny McGovern et al.   JOURNAL OF AUTOIMMUNITY

Low dose interleukin-2 selectively expands circulating regulatory T cells but fails to promote liver allograft tolerance in humans

(2022) Tiong Y. Lim et al.   JOURNAL OF HEPATOLOGY

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulation

(2022) Alan Kennedy et al.   NATURE IMMUNOLOGY

Post-infusion CAR TReg cells identify patients resistant to CD19-CAR therapy

(2022) Zinaida Good et al.   NATURE MEDICINE

Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma

(2022) Nicholas J. Haradhvala et al.   NATURE MEDICINE

Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy

(2022) Sebastian Bittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pancreatic islet-specific engineered T regs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models

(2022) Soo Jung Yang et al.   Science Translational Medicine

Selective decrease of donor-reactive T regs after liver transplantation limits T reg therapy for promoting allograft tolerance in humans

(2022) Qizhi Tang et al.   Science Translational Medicine

Costimulation blockade and Tregs in solid organ transplantation

(2022) Moritz Muckenhuber et al.   Frontiers in Immunology

Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection

(2022) Marcos Iglesias et al.   Frontiers in Immunology

IL-2-based Approaches to Treg Enhancement

(2022) Ffion Harris et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Manufacturing next-generation regulatory T-cell therapies

(2022) Katherine N MacDonald et al.   CURRENT OPINION IN BIOTECHNOLOGY

Flagellin-specific human CAR Tregs for immune regulation in IBD

(2022) Dominic A. Boardman et al.   JOURNAL OF AUTOIMMUNITY

BLIMP1 and NR4A3 transcription factors reciprocally regulate antitumor CAR T cell stemness and exhaustion

(2022) In-Young Jung et al.   Science Translational Medicine

Costimulation blockade in combination with IL-2 permits regulatory T cell sparing immunomodulation that inhibits autoimmunity

(2022) Chun Jing Wang et al.   Nature Communications

Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors

(2022) Jakob Kremer et al.   Frontiers in Immunology

Ex Vivo Expanded Donor Alloreactive Regulatory T Cells Lose Immunoregulatory, Proliferation and Anti-Apoptotic Markers After Infusion Into ATG-Lymphodepleted, Nonhuman Primate Heart Allograft Recipients

(2021) Mohamed B. Ezzelarab et al.   TRANSPLANTATION

Basiliximab impairs regulatory T cell (TREG) function and could affect the short-term graft acceptance in children with heart transplantation

(2021) Jacobo López-Abente et al.   Scientific Reports

Targeted De-Methylation of the FOXP3-TSDR Is Sufficient to Induce Physiological FOXP3 Expression but Not a Functional Treg Phenotype

(2021) Christopher Kressler et al.   Frontiers in Immunology

Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals

(2021) Emily K. Sims et al.   Science Translational Medicine

Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion

(2021) Keli L. Hippen et al.   CYTOTHERAPY

Regulatory T cells and transplantation tolerance: Emerging from the darkness?

(2021) Herman Waldmann   EUROPEAN JOURNAL OF IMMUNOLOGY

CAR- and TRuC-redirected regulatory T cells differ in capacity to control adaptive immunity to FVIII

(2021) Jyoti Rana et al.   MOLECULAR THERAPY

CAR-T cell therapy: current limitations and potential strategies

(2021) Robert C. Sterner et al.   Blood Cancer Journal

Chimeric antigen receptor‐modified human regulatory T cells that constitutively express IL‐10 maintain their phenotype and are potently suppressive

(2021) Yasmin R. Mohseni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells

(2021) Murat Tekguc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function

(2021) Alexander I. Salter et al.   Science Signaling

Optimized CRISPR-mediated gene knockin reveals FOXP3-independent maintenance of human Treg identity

(2021) Avery J. Lam et al.   Cell Reports

Precision Engineering of an Anti-HLA-A2 Chimeric Antigen Receptor in Regulatory T Cells for Transplant Immune Tolerance

(2021) Yannick D. Muller et al.   Frontiers in Immunology

Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives

(2021) Shuntaro Ikegawa et al.   Frontiers in Immunology

The effect of low-dose IL-2 and Treg adoptive cell therapy in patients with type 1 diabetes

(2021) Shen Dong et al.   JCI Insight

Helios is a marker, not a driver, of human Treg stability

(2021) Avery J. Lam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

An autoimmune stem-like CD8 T cell population drives type 1 diabetes

(2021) Sofia V. Gearty et al.   NATURE

Treg engineers take aim at autoimmunity

(2021) Elie Dolgin   NATURE BIOTECHNOLOGY

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

(2021) Baptiste Lamarthée et al.   Nature Communications

Using the T Cell Receptor as a Biomarker in Type 1 Diabetes

(2021) Maki Nakayama et al.   Frontiers in Immunology

Co-Expression of FOXP3FL and FOXP3Δ2 Isoforms Is Required for Optimal Treg-Like Cell Phenotypes and Suppressive Function

(2021) Yohei Sato et al.   Frontiers in Immunology

Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes

(2021) Peter S. Linsley et al.   JCI Insight

Donor‐specific chimeric antigen receptor Tregs limit rejection in naive but not sensitized allograft recipients

(2020) Antoine Sicard et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Regulatory T Cells and Human Disease

(2020) Shimon Sakaguchi et al.   Annual Review of Immunology

Treatment of experimental autoimmune encephalomyelitis with engineered bi-specific Foxp3+ regulatory CD4+ T cells

(2020) Manish Malviya et al.   JOURNAL OF AUTOIMMUNITY

CRISPR-engineered T cells in patients with refractory cancer

(2020) Edward A. Stadtmauer et al.   SCIENCE

A comprehensive review of the impact of tacrolimus intrapatient variability on clinical outcomes in kidney transplantation

(2020) Haley M. Gonzales et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

(2020) Lars Fugger et al.   CELL

Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials

(2020) Birgit Sawitzki et al.   LANCET

CRISPR screen in regulatory T cells reveals modulators of Foxp3

(2020) Jessica T. Cortez et al.   NATURE

CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells

(2020) M. Goodwin et al.   Science Advances

Infectious tolerance. What are we missing?

(2020) Herman Waldmann et al.   CELLULAR IMMUNOLOGY

Inefficient CAR-proximal signaling blunts antigen sensitivity

(2020) Venugopal Gudipati et al.   NATURE IMMUNOLOGY

Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function

(2020) Yuchi Honaker et al.   Science Translational Medicine

CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

(2020) Yuki Imura et al.   JCI Insight

Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

(2020) Devin M. Jones et al.   JOURNAL OF IMMUNOLOGY

Functional CRISPR dissection of gene networks controlling human regulatory T cell identity

(2020) Kathrin Schumann et al.   NATURE IMMUNOLOGY

Functional effects of chimeric antigen receptor co-receptor signaling domains in human regulatory T cells

(2020) Nicholas A. J. Dawson et al.   Science Translational Medicine

A method for expansion and retroviral transduction of mouse regulatory T cells

(2020) Dan Wu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

B7-CD28 co-stimulation modulates central tolerance via thymic clonal deletion and Treg generation through distinct mechanisms

(2020) Masashi Watanabe et al.   Nature Communications

Lentiviral Gene Therapy in HSCs Restores Lineage-Specific Foxp3 Expression and Suppresses Autoimmunity in a Mouse Model of IPEX Syndrome

(2019) Katelyn E. Masiuk et al.   Cell Stem Cell

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

(2019) Kevin H. Toomer et al.   Nature Communications

Innate Control of Tissue-Reparative Human Regulatory T Cells

(2019) Avery J. Lam et al.   JOURNAL OF IMMUNOLOGY

The response to lymphodepletion impacts PFS in aggressive non-Hodgkin lymphoma patients treated with CD19 CAR-T cells

(2019) Alexandre V. Hirayama et al.   BLOOD

Regulatory T cells engineered with a novel insulin-specific chimeric antigen receptor as a candidate immunotherapy for type 1 diabetes

(2019) Michel Tenspolde et al.   JOURNAL OF AUTOIMMUNITY

CTLA-4–mediated transendocytosis of costimulatory molecules primarily targets migratory dendritic cells

(2019) Vitalijs Ovcinnikovs et al.   Science Immunology

Regulatory T Cell Development in the Thymus

(2019) David L. Owen et al.   JOURNAL OF IMMUNOLOGY

Opportunistic Infections in Transplant Patients

(2019) Rebecca Kumar et al.   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions

(2018) R. E. Hoeppli et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Chimeric antigen receptor T cells form nonclassical and potent immune synapses driving rapid cytotoxicity

(2018) A. J. Davenport et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer

(2018) Furong Zeng et al.   Seminars in Immunopathology

Alternative Splicing of FOXP3—Virtue and Vice

(2018) Reiner K. W. Mailer   Frontiers in Immunology

A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity

(2018) Prabhakaran Kumar et al.   JOURNAL OF AUTOIMMUNITY

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Generation of human islet-specific regulatory T cells by TCR gene transfer

(2017) Caroline M. Hull et al.   JOURNAL OF AUTOIMMUNITY

Alloimmune T cells in transplantation

(2017) Susan DeWolf et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-Cell RNA Sequencing Reveals Expanded Clones of Islet Antigen-Reactive CD4+T Cells in Peripheral Blood of Subjects with Type 1 Diabetes

(2017) Karen Cerosaletti et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Low-Affinity TCRs Support Regulatory T Cell Function in Autoimmunity

(2017) Maran L. Sprouse et al.   JOURNAL OF IMMUNOLOGY

Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains

(2017) Daniel T. Harris et al.   JOURNAL OF IMMUNOLOGY

Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing De Novo Autoreactive T-Cell Receptors in Type 1 Diabetes

(2017) Wen-I Yeh et al.   Frontiers in Immunology

A pilot study of operational tolerance with a regulatory T-cell-based cell therapy in living donor liver transplantation

(2016) Satoru Todo et al.   HEPATOLOGY

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Immune-Modulatory Drugs on Regulatory T Cell

(2016) Akiko Furukawa et al.   TRANSPLANTATION

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Novel GMP-Compatible Protocol Employing an Allogeneic B Cell Bank for Clonal Expansion of Allospecific Natural Regulatory T Cells

(2014) S. Landwehr-Kenzel et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

(2014) Y. C. Kim et al.   BLOOD

Reduction in CD4 Central Memory T-Cell Subset in Costimulation Modulator Abatacept-Treated Patients With Recent-Onset Type 1 Diabetes Is Associated With Slower C-Peptide Decline

(2014) T. Orban et al.   DIABETES

Isoform-Specific Inhibition of ROR -Mediated Transcriptional Activation by Human FOXP3

(2014) J. Du et al.   JOURNAL OF IMMUNOLOGY

Suppression of Murine Colitis and its Associated Cancer by Carcinoembryonic Antigen-Specific Regulatory T Cells

(2014) Dan Blat et al.   MOLECULAR THERAPY

The impact of induction therapy on the homeostasis and function of regulatory T cells in kidney transplant patients

(2014) A. P. Bouvy et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Attenuation of Donor-Reactive T Cells Allows Effective Control of Allograft Rejection Using Regulatory T Cell Therapy

(2013) K. Lee et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Clinical Grade Manufacturing of Human Alloantigen-Reactive Regulatory T Cells for Use in Transplantation

(2013) A. L. Putnam et al.   AMERICAN JOURNAL OF TRANSPLANTATION

All-trans retinoic acid and rapamycin synergize with transforming growth factor-β1 to induce regulatory T cells but confer different migratory capacities

(2013) Siddharth Jhunjhunwala et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD4+ T Cells from IPEX Patients Convert into Functional and Stable Regulatory T Cells by FOXP3 Gene Transfer

(2013) L. Passerini et al.   Science Translational Medicine

Differing Effects of Rapamycin or Calcineurin Inhibitor on T-Regulatory Cells in Pediatric Liver and Kidney Transplant Recipients

(2012) T. Akimova et al.   AMERICAN JOURNAL OF TRANSPLANTATION

TCR affinity and specificity requirements for human regulatory T-cell function

(2012) G. Plesa et al.   BLOOD

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells

(2012) A. N. McMurchy et al.   BLOOD

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells

(2012) Wenxian Fu et al.   NATURE IMMUNOLOGY

The Potency of Allospecific Tregs Cells Appears to Correlate With T Cell Receptor Functional Avidity

(2011) J. Y. S. Tsang et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Ex vivo expansion of human Tregs specific for alloantigens presented directly or indirectly

(2011) A. Veerapathran et al.   BLOOD

Genetics of the HLA Region in the Prediction of Type 1 Diabetes

(2011) Janelle A. Noble et al.   Current Diabetes Reports

Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cells

(2011) Vanessa G. Oliveira et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

A role for the transcription factor Helios in human CD4+CD25+ regulatory T cells

(2010) Derese Getnet et al.   MOLECULAR IMMUNOLOGY

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

(2010) Gavin M Bendle et al.   NATURE MEDICINE

Human Antigen-Specific Regulatory T Cells Generated by T Cell Receptor Gene Transfer

(2010) Todd M. Brusko et al.   PLoS One

Special Issue: KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients

(2009)   AMERICAN JOURNAL OF TRANSPLANTATION

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Redirecting human CD4+CD25+ regulatory T cells from the peripheral blood with pre-defined target specificity

(2009) A A Hombach et al.   GENE THERAPY

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

(2009) Nan Zhang et al.   IMMUNITY

Adoptive therapy with redirected primary regulatory T cells results in antigen-specific suppression of arthritis

(2009) Graham P. Wright et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tacrolimus causes a blockage of protein secretion which reinforces its immunosuppressive activity and also explains some of its toxic side-effects

(2009) M.C. Rauch et al.   TRANSPLANT IMMUNOLOGY

Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4+CD25– cells

(2008) Tineke Aarts-Riemens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

DNA methylation controls Foxp3 gene expression

(2008) Julia K. Polansky et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

(2008) Eran Elinav et al.   GASTROENTEROLOGY

Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways

(2008) Brian T. Fife et al.   IMMUNOLOGICAL REVIEWS

Conferring indirect allospecificity on CD4+CD25+ Tregs by TCR gene transfer favors transplantation tolerance in mice

(2008) Julia Yuen-Shan Tsang et al.   JOURNAL OF CLINICAL INVESTIGATION

Ex Vivo Generation of Human Alloantigen-Specific Regulatory T Cells from CD4posCD25high T Cells for Immunotherapy

(2008) Jorieke H. Peters et al.   PLoS One

Generation of Potent and Stable Human CD4+ T Regulatory Cells by Activation-independent Expression of FOXP3

(2007) Sarah E Allan et al.   MOLECULAR THERAPY