Review
Urology & Nephrology
Charles G. Rickert, James F. Markmann
Summary: Solid organ transplantation has been successful in immunosuppression, but there are significant costs and challenges. Immunosuppression and tolerance based on regulatory T cells provide an attractive alternative.
SEMINARS IN NEPHROLOGY
(2022)
Article
Genetics & Heredity
Sabine Muth, Annekatrin Klaric, Markus Radsak, Hansjoerg Schild, Hans Christian Probst
Summary: Treg-expressed CD27 maintains DC tolerogenic in steady state and limits anti-tumor immunity; Ablation of Treg-expressed CD27 synergizes with PD-1 blockade to improve CTL-mediated tumor control.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Immunology
Bruce M. Hall, Rachael M. Hall, Giang T. Tran, Catherine M. Robinson, Paul L. Wilcox, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Suzanne J. Hodgkinson
Summary: The CD4(+)CD25(+)Foxp3(+)T cell population is heterogeneous, consisting of three major subgroups with different functions and characteristics. Treatment with rIL-5 can prevent rejection of transplants by activating Ts2 cells and Th2-like Treg. This therapeutic approach significantly improves survival rates and reduces rejection reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Casey O. Lightbourn, Dietlinde Wolf, Sabrina N. Copsel, Ying Wang, Brent J. Pfeiffer, Henry Barreras, Cameron S. Bader, Krishna V. Komanduri, Victor L. Perez, Robert B. Levy
Summary: Cyclophosphamide administered post hematopoietic stem cell transplantation may prolong survival of solid organ transplants by deleting or suppressing allo-reactive T cells, potentially reducing rejection responses. The timing of post-transplant cyclophosphamide administration is critical for the success of corneal transplants.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jie Sun, Guang-Peng Zhou, Shi-Peng Li, Xiao-Jie Chen, Jin-Ming Zhang, Yi-Zhou Jiang, Bin Cui, Hai-Ming Zhang, Li-Ying Sun, Zhi-Jun Zhu
Summary: The role of ILC2s in acute rejection after liver transplantation remains unclear. This study found that hepatic ILC2s were significantly increased in rejection cases compared to non-rejection cases, and there was a close correlation between hepatic ILC2s and Treg cells. The number of allograft infiltrating ILC2s may play inhibitory roles in posttransplant immune homeostasis, favoring resolution of liver allograft rejection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Pierre Henschel, Sybille Landwehr-Kenzel, Niklas Engels, Andrea Schienke, Jakob Kremer, Tobias Riet, Nella Redel, Konstantinos Iordanidis, Valerie Saetzler, Katharina John, Miriam Heider, Matthias Hardtke-Wolenski, Heiner Wedemeyer, Elmar Jaeckel, Fatih Noyan
Summary: Researchers have developed an HLA-A2specific CAR vector that co-expresses FOXP3, which can increase the safety and efficacy of CAR-Treg products. Stable expression of FOXP3 in Tregs prevents conversion into pathogenic T effector cells under pro-inflammatory conditions.
JOURNAL OF AUTOIMMUNITY
(2023)
Article
Immunology
Cheng-Hung Lin, Madonna Rica Anggelia, Hui-Yun Cheng, Yun-Huan Hsieh, Wen-Yu Chuang, Huang-Yu Yang, Chih-Hung Lin
Summary: This study demonstrated that VBM transplantation is an efficient strategy to induce and maintain donor-specific tolerance for an osseous-free allograft.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Tomoki Murata, Naoki Hama, Tomoki Kamatani, Akihiro Mori, Ryo Otsuka, Haruka Wada, Ken-ichiro Seino
Summary: This study investigated the immune regulation in transplantation using allogeneic induced pluripotent stem cells (iPSCs). The researchers found that minor antigen mismatches are a risk factor for graft rejection, highlighting the importance of immune regulation. They demonstrated that iPSC-derived hematopoietic stem/progenitor cells (iHSPCs) can induce allograft tolerance, providing a new approach for transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Plant Sciences
Yuanduo Wang, Piaopiao Tan, Liang Chang, Zheming Yue, Chaozhen Zeng, Mei Li, Zhixiang Liu, Xujie Dong, Mingli Yan
Summary: Exogenous proline treatment enhances the tolerance of Brassica juncea to cadmium by reducing cadmium accumulation and reestablishing redox homeostasis.
Review
Immunology
Brian H. Johnstone, Franka Messner, Gerald Brandacher, Erik J. Woods
Summary: Induction of immune tolerance for solid organ and vascular composite allografts is crucial in transplantation medicine to avoid lifelong immunosuppression. The most promising means of tolerance induction is through transplantation of donor hematopoietic stem cells, but durable immune tolerance has not been achieved on a large scale in other solid organs or vascular composite allografts. Ossium Health has established a bank of cryopreserved bone marrow from deceased organ donor vertebral bodies, which has the potential to be a valuable resource for treating hematological malignancies and inducing transplant tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Tomoki Murata, Ryo Otsuka, Airi Sasaki, Tomoki Kamatani, Haruka Wada, Hisashi Yamakawa, Yoshinori Hasegawa, Ken-ichiro Seino
Summary: When considering cellular or tissue transplantation using iPSCs, the use of allogeneic ones is being considered due to time and economic cost. Immune regulation is crucial in successful allogeneic transplantation. While efforts have been made to eliminate the effects of MHC on iPSC-derived grafts, minor antigen-induced rejection cannot be ignored.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Immunology
Sam R. Adhikary, Peter Cuthbertson, Leigh Nicholson, Katrina M. Bird, Chloe Sligar, Min Hu, Philip J. O'Connell, Ronald Sluyter, Stephen Alexander, Debbie Watson
Summary: This study demonstrates that PTCy reduces GVHD in a preclinical humanized mouse model by depleting reactive human donor T cells and reducing human Tregs, resulting in decreased weight loss, clinical GVHD, and improved survival.
Article
Plant Sciences
Nan Hou, Chaoshuo Li, Jieqiang He, Yu Liu, Sisi Yu, Mickael Malnoy, Muhammad Mobeen Tahir, Lingfei Xu, Fengwang Ma, Qingmei Guan
Summary: This study reveals the global involvement and molecular regulatory mechanism of N-6-methyladenosine modification (m(6)A) in the drought response of perennial apple trees, providing candidate genes for the breeding of stress-tolerant apple cultivars.
Article
Biochemistry & Molecular Biology
Bei-Chia Guo, Ko-Lin Kuo, Jenq-Wen Huang, Chia-Hui Chen, Der-Cherng Tarng, Tzong-Shyuan Lee
Summary: During hemodialysis, phthalates leaching from medical tubes interfere with the lipid-lowering effect of statins by activating the NOX-ROS-TRPA1 pathway and down-regulating the expression of low-density lipoprotein receptor (LDLR) through PPAR gamma-PCSK9 and LXR alpha-IDOL signaling. As a result, the statin-mediated lipid-lowering effect is diminished in hepatocytes.
Article
Surgery
Nattawat Klomjit, Mireille El Ters, Benjamin A. Adam, Priya Sampathkumar, Raymund R. Razonable, Sandra J. Taler, Timucin Taner, Mariam Priya Alexander
Summary: Neutralizing monoclonal antibodies like bamlanivimab show promise in treating COVID-19 in kidney transplant recipients, but their impact on kidney allograft histology is unclear. A case study reported diffuse peritubular capillary C4d staining following bamlanivimab treatment in a kidney transplant recipient with stable kidney function at 6 months post-biopsy.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
Kristopher P. Croome, Amit K. Mathur, Bashar Aqel, Liu Yang, Timucin Taner, Julie K. Heimbach, Charles B. Rosen, Ricardo Paz-Fumagalli, C. Burcin Taner
Summary: This study provides a detailed analysis of the natural history and clinical course of IC, showing that IC can be classified into 4 distinct patterns with different clinical courses.
Editorial Material
Gastroenterology & Hepatology
Michael J. Levy, Emily C. Bendel, Haraldur Bjarnason, Christopher J. Reisenauer, Hatem Amer, Don C. Codipilly, Patrick G. Dean, Ferga C. Gleeson, Julie K. Heimbach, Manju Kalra, Mikel Prieto, Mark D. Stegall, Timucin Taner, Patrick S. Kamath
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Daniel S. Ramon, Danielle M. Troop, Theresa N. Kinard, Caroline C. Jadlowiec, Margaret S. Ryan, Winston R. Hewitt, Linda G. Olsen, Andres Jaramillo, Timucin Taner, Raymond L. Heilman
Summary: Simultaneous liver-kidney transplant (SLKT) with donor-specific antibodies (DSA) is common, but after a second liver transplant, an abrupt increase in DSA levels against the kidney led to antibody-mediated rejection (AMR). The clearance of antibodies depended on the HLA antigens expressed by the transplanted liver cells.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Editorial Material
Surgery
John R. Greenland, John F. McDyer
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Alyson N. Fox, AnnMarie Liapakis, Ramesh Batra, Therese Bittermann, Juliet Emamaullee, Sukru Emre, Yuri Genyk, Hyosun Han, Whitney Jackson, Elizabeth Pomfret, Muhammad Raza, Manuel Rodriguez-Davalos, Susan Rubman Gold, Benjamin Samstein, Akhil Shenoy, Timucin Taner, John P. Roberts
Summary: This article reviews the increasing interest in anonymous nondirected living organ donation in the United States, discusses current transplant policy and emerging data in living donor liver transplantation, and aims to provide consensus guidance for safe evaluation and selection of nondirected living liver donors and just allocation of grafts.
Editorial Material
Gastroenterology & Hepatology
Randi J. Ryan, Timucin Taner, Julie K. Heimbach
LIVER TRANSPLANTATION
(2022)
Article
Respiratory System
Catarina Aragon Pinto, Vivek Iyer, Yahya A. Almodallal, Hasan Albitar, Hilary Dubrock, Hector Cajigas, Julie K. Heimbach, Charles B. Rosen, Kimberly Watt, Timucin Taner, Scott Nyberg, Hugo Vargas, Rodrigo Cartin-Ceba, Andrew P. Keaveny, Michael Krowka, Alice Gallo de Moraes
Summary: This study retrospectively analyzed hospital and intensive care unit outcomes in patients with hepatopulmonary syndrome (HPS) following liver transplantation. The results showed that most HPS patients had short durations of invasive mechanical ventilation, ICU stay, and hospital stay post-transplant, and the severity of HPS did not impact hospital mortality.
Article
Surgery
Daniel R. Calabrese, Tiffany Chong, Jonathan P. Singer, Raja Rajalingam, Steven R. Hays, Jasleen Kukreja, Lorriana Leard, Jeffrey A. Golden, Lewis L. Lanier, John R. Greenland
Summary: Acute and chronic rejections limit the long-term survival after lung transplant. Pulmonary antibody-mediated rejection (AMR) is an incompletely understood driver of long-term outcomes characterized by donor-specific antibodies (DSAs), innate immune infiltration, and evidence of complement activation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Naba Farooqui, Mark Zaidi, Lisa Vaughan, Trevor D. McKee, Eram Ahsan, Kevin D. Pavelko, Jose C. Villasboas, Svetomir Markovic, Timucin Taner, Nelson Leung, Haidong Dong, Mariam P. Alexander, Sandra M. Herrmann
Summary: This study found that immune checkpoint inhibitors (ICIs) therapy may lead to acute kidney injury (AKI) and there are no biomarkers currently available to distinguish AKI caused by ICIs from other causes. The urine levels of cytokines such as TNF-a, IL-2, and IL-10 were significantly higher in AKI-ICI patients. Therefore, these T-cell responses and their respective cytokines may be helpful in differentiating AKI-ICI from AKI-other.
KIDNEY INTERNATIONAL REPORTS
(2023)
Editorial Material
Multidisciplinary Sciences
Qizhi Tang
Summary: Inflammation caused by surgical trauma hinders the survival of transplanted stem-cell-derived neurons in rodent models of Parkinson's disease. However, co-transplanting regulatory T cells enhances the efficacy of the therapy.
Article
Biochemical Research Methods
Pierce Hadley, Yuanzhou Chen, Lariana Cline, Zhiyuan Han, Qizhi Tang, Xiao Huang, Tejal Desai
Summary: The biofunctionalization of synthetic materials has extensive utility for biomedical applications. However, current approaches to bioconjugation often lack efficiency and controllability. This study presents a novel method using synthetic DNA scaffolds on biomaterial surfaces to precisely control cargo density and ratio, improving the assembly and organization of functional cargos. The results demonstrate that this approach can be utilized for the modulation and phenotypic adaptation of immune cells.
Article
Surgery
Brittany Koons, Michaela R. Anderson, Patrick J. Smith, John R. Greenland, Jonathan P. Singer
Summary: Older adults, aged 65 and above, are the fastest growing age group undergoing lung transplantation. Emerging evidence suggests that measures of physiological age, such as frailty and neurocognitive function, may better predict poor transplant outcomes than chronological age. Efforts are needed to improve outcomes for this growing cohort of older lung transplant patients through better risk assessment and interventions targeting physiological aging.
CURRENT TRANSPLANTATION REPORTS
(2022)
Article
Gastroenterology & Hepatology
Nidhi Jalan-Sakrikar, Thiago M. De Assuncao, Amaia Navarro-Corcuera, Feda H. Hamdan, Lorena Loarca, Lindsey A. Kirkeby, Zachary T. Resch, Steven P. O'Hara, Brian D. Juran, Konstantinos N. Lazaridis, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Vijay H. Shah, Nicholas F. LaRusso, Robert C. Huebert
Summary: The research team successfully generated specific cholangiocytes and biliary organoids from patients with PSC, revealing an intrinsic predisposition to cellular senescence in PSC cholangiocytes.
HEPATOLOGY COMMUNICATIONS
(2022)