CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD

Sustained B cell depletion by CD19-targeted CAR T cells is a highly effective treatment for murine lupus

(2019) Rita Kansal et al.   Science Translational Medicine

Human FOXP3+ Regulatory T Cell Heterogeneity and Function in Autoimmunity and Cancer

(2019) James B. Wing et al.   IMMUNITY

B cell checkpoints in autoimmune rheumatic diseases

(2019) Samuel J. S. Rubin et al.   Nature Reviews Rheumatology

New therapies for systemic lupus erythematosus — past imperfect, future tense

(2019) Grainne Murphy et al.   Nature Reviews Rheumatology

Targeting cardiac fibrosis with engineered T cells

(2019) Haig Aghajanian et al.   NATURE

The NOTCH-FOXM1 Axis Plays a Key Role in Mitochondrial Biogenesis in the Induction of Human Stem Cell Memory-like CAR-T Cells

(2019) Taisuke Kondo et al.   CANCER RESEARCH

Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells

(2018) Yong Chan Kim et al.   JOURNAL OF AUTOIMMUNITY

B cells in the pathogenesis of primary Sjögren syndrome

(2018) Gaëtane Nocturne et al.   Nature Reviews Rheumatology

Mechanistic Insights into Autoimmune Pancreatitis and IgG4-Related Disease

(2018) Tomohiro Watanabe et al.   TRENDS IN IMMUNOLOGY

Generation of allo-antigen-specific induced Treg stabilized by vitamin C treatment and its application for prevention of acute graft versus host disease model

(2017) Hidenori Kasahara et al.   INTERNATIONAL IMMUNOLOGY

TGF-β3 Inhibits Antibody Production by Human B Cells

(2017) Yumi Tsuchida et al.   PLoS One

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

(2017) Taisuke Kondo et al.   Nature Communications

Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision

(2017) Patrick R. Adair et al.   Frontiers in Immunology

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

(2017) Nicholas A. J. Dawson et al.   Frontiers in Immunology

FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII

(2016) Jeongheon Yoon et al.   BLOOD

Garp as a therapeutic target for modulation of T regulatory cell function

(2016) Ethan M. Shevach   EXPERT OPINION ON THERAPEUTIC TARGETS

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor

(2016) Katherine G. MacDonald et al.   JOURNAL OF CLINICAL INVESTIGATION

Induced Regulatory T Cells: Their Development, Stability, and Applications

(2016) Mitsuhiro Kanamori et al.   TRENDS IN IMMUNOLOGY

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

(2015) X. Liu et al.   CANCER RESEARCH

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

(2015) Anke Theil et al.   CYTOTHERAPY

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

Engineered antigen-specific human regulatory T cells: immunosuppression of FVIII-specific T- and B-cell responses

(2014) Y. C. Kim et al.   BLOOD

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia

(2014) M. L. Davila et al.   Science Translational Medicine

Toxicity management for patients receiving novel T-cell engaging therapies

(2013) David M. Barrett et al.   CURRENT OPINION IN PEDIATRICS

Human T cells depend on functional calcineurin, tumour necrosis factor-α and CD80/CD86 for expansion and activation in mice

(2012) H. Søndergaard et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Administration of CD4+CD25highCD127- Regulatory T Cells Preserves  -Cell Function in Type 1 Diabetes in Children

(2012) N. Marek-Trzonkowska et al.   DIABETES CARE

CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery

(2012) Moa Fransson et al.   Journal of Neuroinflammation

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

(2011) M. Di Ianni et al.   BLOOD

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

(2011) Kenji Ichiyama et al.   IMMUNITY

Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells

(2011) P. Sagoo et al.   Science Translational Medicine

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

Amelioration of Colitis by Genetically Engineered Murine Regulatory T Cells Redirected by Antigen-Specific Chimeric Receptor

(2009) Eran Elinav et al.   GASTROENTEROLOGY

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL