Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Min Hu, Natasha M. Rogers, Jennifer Li, Geoff Y. Zhang, Yuan Min Wang, Karli Shaw, Philip J. O'Connell, Stephen Alexander
Summary: Tregs play a crucial role in kidney transplantation by limiting immune activation and potentially reducing the need for immunosuppression. Studies have shown their importance in improving allo-specific Treg function in both animal and human models.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Ilse Gille, Frans H. J. Claas, Geert W. Haasnoot, Mirjam H. M. Heemskerk, Sebastiaan Heidt
Summary: Solid organ transplantation is an effective treatment for end-stage diseases, but the need for immunosuppression can lead to serious side effects. CAR Treg therapy, specifically with HLA-A2 CAR Tregs, shows potential in promoting transplantation tolerance and improving graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander Merleev, Flavio Vincenti, Emanual Maverakis, Angus W. Thomson, Qizhi Tang
Summary: In this study comparing arTregs expanded ex vivo using different types of antigen-presenting cells, it was found that sDCs stimulated Tregs to expand in much larger numbers. Additionally, sDC-generated arTregs expressed higher levels of CD80, CD86, and T cell-attracting chemokines, indicating their superior expansion-inducing capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Aikaterini Hatzioannou, Athina Boumpas, Miranta Papadopoulou, Iosif Papafragkos, Athina Varveri, Themis Alissafi, Panayotis Verginis
Summary: Treg cell plasticity plays a significant role in autoimmunity and cancer, characterized by loss of Foxp3 expression. It has great therapeutic potential through destabilizing Treg cells to promote anti-tumor immunity or enhancing Treg cell stability to attenuate chronic inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Natalia M. Krajewska, Remi Fiancette, Ye H. Oo
Summary: Immune-mediated cholangiopathies are characterized by the destruction of bile ducts, leading to liver inflammation and fibrosis. Regulatory T cells (Tregs) play a crucial role in these diseases, but their function can be impaired by the inflamed microenvironment. Mast cells (MCs) are also involved in the pathogenesis by releasing pro-inflammatory mediators. MCs can indirectly influence Treg function and there are also direct interactions between MCs and Tregs. Understanding the crosstalk between Tregs and MCs is important for the progression of autoimmune cholangiopathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jian Lu, Peiyuan Li, Xuezhi Du, Yanhong Liu, Baotong Zhang, Feng Qi
Summary: Regulatory T cells (Tregs) are promising research targets for inducing immune tolerance in organ transplantation, and Treg-based cellular therapies have shifted towards clinical trials for transplantation.
TRANSPLANT IMMUNOLOGY
(2021)
Review
Immunology
Qi Jiang, Guocan Yang, Qi Liu, Shengjun Wang, Dawei Cui
Summary: Rheumatoid arthritis is a systemic and heterogeneous autoimmune disease characterized by symmetrical polyarthritis, with dysfunction of regulatory T (Treg) cells potentially contributing to the breakdown of self-tolerance. The ideal treatment strategy for RA should focus on re-inducing self-tolerance to prevent obvious tissue injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Sharad K. Mittal, WonKyung Cho, Elsayed Elbasiony, Yilin Guan, William Foulsham, Sunil K. Chauhan
Summary: The study showed that CD80 in MSCs plays a crucial role in modulating Treg function. In vitro and in vivo experiments, as well as a mouse transplantation model, demonstrated the impact of CD80 on Tregs.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Immunology
Gabriel Orozco, Meera Gupta, Roberto Gedaly, Francesc Marti
Summary: This review discusses the major challenges that Treg cell transplant investigators currently face, including Treg cell diversity, manufacturing process, administration route, and lack of effective monitoring and biomarkers.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Prerana Muralidhara, Vanshika Sood, Vishnu Vinayak Ashok, Kushagra Bansal
Summary: Immunological tolerance is critical during pregnancy to protect the semi-allogeneic fetus from immune responses. Regulatory T cells (Tregs) accumulate at the placenta in the uterus during pregnancy and confer immunological tolerance at the maternal-fetal interface. Tregs play a role in supporting proper growth of the embryo during pregnancy and their dysfunction is associated with pregnancy-related complications. Tregs also have a similar role in tumor immunity by creating a tolerogenic system.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Fatemeh Bayati, Mahsa Mohammadi, Maryam Valadi, Saeid Jamshidi, Arron Munggela Foma, Ehsan Sharif-Paghaleh
Summary: Regulatory T cells (Tregs) are a subgroup of CD4(+) T cells that play a key role in immune tolerance regulation, preventing autoimmunity and aiding tumor evasion of immune recognition. Their therapeutic potential in transplantation, autoimmune diseases, and cancer therapy is being actively studied for improving treatment options.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Xinting Wang, Hua Zhou, Qian Liu, Peipei Cheng, Tingyao Zhao, Tianshu Yang, Yue Zhao, Wanjing Sha, Yanyan Zhao, Huiyan Qu
Summary: Cardiovascular diseases (CVDs) are a major cause of global death and disability, with inflammatory progression and immune responses playing a crucial role. Regulatory T cells (Tregs), as a subset of CD4(+)T cells, have immunosuppressive function and are important in inflammatory diseases. Using Tregs as biomarkers or targeting them for cardioprotective effects by regulating immune balance, suppressing inflammation, and promoting cardiac regeneration has become a research focus in CVD treatment. However, Tregs have plasticity and can lose their immunosuppressive function, causing toxic effects on target organs in certain diseases. This review provides an overview of Tregs' role in CVDs, discusses their plasticity, and lays a foundation for future studies targeting Tregs in CVD prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Ke-jia Wu, Qu-fei Qian, Jin-ren Zhou, Dong-lin Sun, Yun-fei Duan, Xi Zhu, Kurt Sartorius, Yun-jie Lu
Summary: The human liver plays crucial roles in synthesizing extracellular matrix (ECM) and regulating fibrogenesis for maintaining homeostasis. Chronic liver injury induces fibrogenesis due to the imbalance between ECM accumulation and fibrosis resolution. Liver diseases that cause fibrogenesis are associated with various risk factors, including hepatitis infection, schistosomiasis, alcohol, certain drugs, toxicants, diabetes, and obesity. Hepatic stellate cells (HSCs) activation, which generate and accumulate ECM, is a key event in liver fibrosis. The paper reviews the dual role of regulatory T-cells (Tregs) in liver fibrogenesis, including their promotion of immunosuppression and activation of fibrosis. Understanding the contradictory roles of Tregs in different immune microenvironments and molecular pathways is important for managing liver fibrosis.
CELL DEATH DISCOVERY
(2023)
Review
Immunology
Nardos Cheru, David A. Hafler, Tomokazu S. Sumida
Summary: Maintenance of peripheral tolerance by CD4(+)Foxp3(+) regulatory T cells is crucial for regulating autoreactive T cells. Dysfunction of Foxp3 leads to autoimmune diseases. Tregs not only maintain immune homeostasis, but also establish tissue microenvironment and homeostasis of non-lymphoid tissues. Tissue resident Tregs show unique profiles and interact with both immune and non-immune cells, exerting suppressive function and adopting to local microenvironment through bidirectional interactions.
FRONTIERS IN IMMUNOLOGY
(2023)