Dynamic Roles for IL-2–STAT5 Signaling in Effector and Regulatory CD4+ T Cell Populations

Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4+ T Cells

(2020) Anna Śledzińska et al.   IMMUNITY

A distal enhancer at risk locus 11q13.5 promotes suppression of colitis by Treg cells

(2020) Rabab Nasrallah et al.   NATURE

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells

(2019) Kevin H. Toomer et al.   Nature Communications

The γc Family of Cytokines: Basic Biology to Therapeutic Ramifications

(2019) Warren J. Leonard et al.   IMMUNITY

T Follicular Helper Cell Biology: A Decade of Discovery and Diseases

(2019) Shane Crotty   IMMUNITY

Guidance factors orchestrating regulatory T cell positioning in tissues during development, homeostasis, and response

(2019) Thorsten R. Mempel et al.   IMMUNOLOGICAL REVIEWS

BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors

(2019) Jessica A. Kotov et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance

(2019) Zinan Zhang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Flip the coin: IL-7 and IL-7R in health and disease

(2019) João T. Barata et al.   NATURE IMMUNOLOGY

Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19

(2019) Masahiko Akamatsu et al.   Science Immunology

Signaling and Function of Interleukin-2 in T Lymphocytes

(2018) Sarah H. Ross et al.   Annual Review of Immunology

The role of cytokines in T-cell memory in health and disease

(2018) Miro E. Raeber et al.   IMMUNOLOGICAL REVIEWS

Characterization of Blimp-1 function in effector regulatory T cells

(2018) Erika Cretney et al.   JOURNAL OF AUTOIMMUNITY

Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer

(2018) Bettina Wingelhofer et al.   LEUKEMIA

Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes

(2018) Jonathan T. Sockolosky et al.   SCIENCE

Unexpected Help: Follicular Regulatory T Cells in the Germinal Center

(2018) Markus M. Xie et al.   Frontiers in Immunology

Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cells

(2018) Daniel DiToro et al.   SCIENCE

IL-2 Inhibition of Th17 Generation Rather Than Induction of Treg Cells Is Impaired in Primary Sjögren’s Syndrome Patients

(2018) Jing Luo et al.   Frontiers in Immunology

Several Follicular Regulatory T Cell Subsets With Distinct Phenotype and Function Emerge During Germinal Center Reactions

(2018) Nicolas Fazilleau et al.   Frontiers in Immunology

Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism

(2018) Marc O. Johnson et al.   CELL

Differential Roles of IL-2 Signaling in Developing versus Mature Tregs

(2018) Martin Y. Fan et al.   Cell Reports

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

(2017) Frederick Arce Vargas et al.   IMMUNITY

CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs

(2017) Danielle A. Chisolm et al.   IMMUNITY

STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of theIl2ragene locus

(2017) Peng Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A distinct subpopulation of CD25−T-follicular regulatory cells localizes in the germinal centers

(2017) James Badger Wing et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytokine Signaling in the Development and Homeostasis of Regulatory T cells

(2017) Kevin H. Toomer et al.   Cold Spring Harbor Perspectives in Biology

Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4

(2017) Lucia Campos Carrascosa et al.   Nature Communications

Role of TET enzymes in DNA methylation, development, and cancer

(2016) Kasper Dindler Rasmussen et al.   GENES & DEVELOPMENT

An essential role for the IL-2 receptor in Treg cell function

(2016) Takatoshi Chinen et al.   NATURE IMMUNOLOGY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

(2016) Valerie A Gerriets et al.   NATURE IMMUNOLOGY

Low-dose interleukin-2 treatment selectively modulates CD4+ T cell subsets in patients with systemic lupus erythematosus

(2016) Jing He et al.   NATURE MEDICINE

Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism

(2016) M. Peng et al.   SCIENCE

Improved cancer immunotherapy by a CD25-mimobody conferring selectivity to human interleukin-2

(2016) N. Arenas-Ramirez et al.   Science Translational Medicine

TH9 cells in anti-tumor immunity

(2016) Thaiz Rivera Vargas et al.   Seminars in Immunopathology

Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells

(2016) Meryem Aloulou et al.   Nature Communications

IL-7 signalling represses Bcl-6 and the TFH gene program

(2016) Paul W. McDonald et al.   Nature Communications

Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation

(2016) Xindong Liu et al.   Cell Reports

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

(2016) Alejandro Villarino et al.   eLife

Insights into Cytokine–Receptor Interactions from Cytokine Engineering

(2015) Jamie B. Spangler et al.   Annual Review of Immunology

T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production

(2015) Jinfang Zhu   CYTOKINE

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms

(2015) Jamie B. Spangler et al.   IMMUNITY

The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells

(2015) John P. Ray et al.   IMMUNITY

Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps

(2015) Suman Mitra et al.   IMMUNITY

Hydrogen Sulfide Promotes Tet1- and Tet2-Mediated Foxp3 Demethylation to Drive Regulatory T Cell Differentiation and Maintain Immune Homeostasis

(2015) Ruili Yang et al.   IMMUNITY

Interplay between mTOR and STAT5 signaling modulates the balance between regulatory and effective T cells

(2015) Juan Shan et al.   IMMUNOBIOLOGY

The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

(2015) Mélanie Bruchard et al.   NATURE IMMUNOLOGY

Dual-Specificity Phosphatase 4 Regulates STAT5 Protein Stability and Helper T Cell Polarization*

(2015) Wan-Yi Hsiao et al.   PLoS One

Control of the Inheritance of Regulatory T Cell Identity by a cis Element in the Foxp3 Locus

(2014) Yongqiang Feng et al.   CELL

Bcl-6 directly represses the gene program of the glycolysis pathway

(2014) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression

(2014) Wei Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FoxP3+ regulatory T cells promote influenza-specific Tfh responses by controlling IL-2 availability

(2014) Beatriz León et al.   Nature Communications

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

(2013) Chih-Hao Chang et al.   CELL

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells

(2013) Jennifer A. Jenks et al.   CLINICAL IMMUNOLOGY

Interleukin-2 at the Crossroads of Effector Responses, Tolerance, and Immunotherapy

(2013) Wei Liao et al.   IMMUNITY

Th9 cells: differentiation and disease

(2013) Mark H. Kaplan   IMMUNOLOGICAL REVIEWS

CD4 T cell-intrinsic IL-2 signaling differentially affects Th1 and Th17 development

(2013) Kenjiro Fujimura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Validated Regulatory Network for Th17 Cell Specification

(2012) Maria Ciofani et al.   CELL

Critical Role of STAT5 Transcription Factor Tetramerization for Cytokine Responses and Normal Immune Function

(2012) Jian-Xin Lin et al.   IMMUNITY

Interleukin-2 Inhibits Germinal Center Formation by Limiting T Follicular Helper Cell Differentiation

(2012) André Ballesteros-Tato et al.   IMMUNITY

STAT5 Protein Negatively Regulates T Follicular Helper (Tfh) Cell Generation and Function

(2012) Roza I. Nurieva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

STAT5 is a potent negative regulator of TFHcell differentiation

(2012) Robert J. Johnston et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exploiting a natural conformational switch to engineer an interleukin-2 ‘superkine’

(2012) Aron M. Levin et al.   NATURE

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

(2012) Kenneth J Oestreich et al.   NATURE IMMUNOLOGY

DUSP4 deficiency enhances CD25 expression and CD4+T-cell proliferation without impeding T-cell development

(2011) Ching-Yu Huang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

(2011) Marion Pepper et al.   IMMUNITY

Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types

(2011) Gang Wei et al.   IMMUNITY

Regulatory T cells and Foxp3

(2011) Alexander Y. Rudensky   IMMUNOLOGICAL REVIEWS

IL-2 Regulates Expression of C-MAF in Human CD4 T Cells

(2011) A. Rani et al.   JOURNAL OF IMMUNOLOGY

A Brief History of IL-9

(2011) R. Goswami et al.   JOURNAL OF IMMUNOLOGY

Regulation of the Germinal Center Reaction by Foxp3+ Follicular Regulatory T Cells

(2011) I. Wollenberg et al.   JOURNAL OF IMMUNOLOGY

STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease

(2011) Kari Nadeau et al.   JOURNAL OF PEDIATRICS

Epigenetic repression of the Igk locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2

(2011) Malay Mandal et al.   NATURE IMMUNOLOGY

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

(2011) Wei Liao et al.   NATURE IMMUNOLOGY

Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5

(2011) Xiang-Ping Yang et al.   NATURE IMMUNOLOGY

Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions

(2011) Yeonseok Chung et al.   NATURE MEDICINE

Foxp3+ follicular regulatory T cells control the germinal center response

(2011) Michelle A Linterman et al.   NATURE MEDICINE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells

(2010) Yenkel Grinberg-Bleyer et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation

(2010) Hua-Chen Chang et al.   NATURE IMMUNOLOGY

IL-2/anti-IL-2 antibody complexes show strong biological activity by avoiding interaction with IL-2 receptor   subunit CD25

(2010) S. Letourneau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival

(2010) T. W. Hand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

(2009) Di Yu et al.   IMMUNITY

Control of Regulatory T Cell Lineage Commitment and Maintenance

(2009) Steven Z. Josefowicz et al.   IMMUNITY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Eos Mediates Foxp3-Dependent Gene Silencing in CD4+ Regulatory T Cells

(2009) F. Pan et al.   SCIENCE

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

(2009) R. J. Johnston et al.   SCIENCE

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

A Fundamental Role for Interleukin-21 in the Generation of T Follicular Helper Cells

(2008) Alexis Vogelzang et al.   IMMUNITY

Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction

(2008) Qizhi Tang et al.   IMMUNITY

T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

(2008) Xuexian O. Yang et al.   IMMUNITY

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

(2008) Fuping Zhang et al.   NATURE IMMUNOLOGY

Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

(2008) Marc Veldhoen et al.   NATURE IMMUNOLOGY

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

(2008) Wei Liao et al.   NATURE IMMUNOLOGY

IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

(2008) Valérie Dardalhon et al.   NATURE IMMUNOLOGY

The Biology of Interleukin-2

(2007) Thomas R. Malek   Annual Review of Immunology

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology