Harnessing Treg Homeostasis to Optimize Posttransplant Immunity: Current Concepts and Future Perspectives

Maturation and Phenotypic Heterogeneity of Human CD4+ Regulatory T Cells From Birth to Adulthood and After Allogeneic Stem Cell Transplantation

(2021) Tiago R. Matos et al.   Frontiers in Immunology

Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide

(2021) Benedetta Rambaldi et al.   Blood Advances

Allogeneic transplantation after PD-1 blockade for classic Hodgkin lymphoma

(2021) Reid W. Merryman et al.   LEUKEMIA

Pretransplant nivolumab further enhanced Treg expansion after posttransplant cyclophosphamide; another aspect for immune tolerance by PTCy after nivolumab

(2021) Shuntaro Ikegawa et al.   LEUKEMIA

Identification of resistance pathways and therapeutic targets in relapsed multiple myeloma patients through single-cell sequencing

(2021) Yael C. Cohen et al.   NATURE MEDICINE

Haploidentical age-adapted myeloablative transplant and regulatory and effector T cells for acute myeloid leukemia

(2021) Antonio Pierini et al.   Blood Advances

RNA-seq of human T cells after hematopoietic stem cell transplantation identifies Linc00402 as a regulator of T cell alloimmunity

(2021) Daniel Peltier et al.   Science Translational Medicine

Donor Treg expansion by liposomal α‐galactosylceramide modulates Tfh cells and prevents sclerodermatous chronic graft‐versus‐host disease

(2021) Hiroyuki Sugiura et al.   Immunity Inflammation and Disease

Reduced dose of PTCy followed by adjuvant α-galactosylceramide enhances GVL effect without sacrificing GVHD suppression

(2021) Makoto Nakamura et al.   Scientific Reports

Sustained Immunogenic and Clinical Effects of Low-Dose Interleukin-2 Therapy with an Intermittent Maintenance Method for Refractory Chronic Graft-Versus-Host Disease: Results of Phase1/2a LDIL2-01 Study

(2020) Yusuke Meguri et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Posttransplantation cyclophosphamide improves transplantation outcomes in patients with AML/MDS who are treated with checkpoint inhibitors

(2020) Betül Oran et al.   CANCER

Posttransplant cyclophosphamide after allogeneic hematopoietic cell transplantation mitigates the immune activation induced by previous nivolumab therapy

(2020) Juan C. Nieto et al.   LEUKEMIA

Dissecting the biology of allogeneic HSCT to enhance the GvT effect whilst minimizing GvHD

(2020) Bruce R. Blazar et al.   Nature Reviews Clinical Oncology

Ruxolitinib for Glucocorticoid-Refractory Acute Graft-versus-Host Disease

(2020) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-Myeloablative Allogeneic Transplantation with Post-Transplant Cyclophosphamide after Immune Checkpoint Inhibition for Classic Hodgkin Lymphoma: A Retrospective Cohort Study

(2020) Suman Paul et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

(2020) Joel Kidman et al.   Frontiers in Immunology

Targeting Interleukin-2-Inducible T-Cell Kinase (ITK) Differentiates GVL and GVHD in Allo-HSCT

(2020) Mahinbanu Mammadli et al.   Frontiers in Immunology

Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report

(2019) Lucy B. Cook et al.   JOURNAL OF CLINICAL ONCOLOGY

Immune Reconstitution after T-cell Replete HLA-Haploidentical Transplantation

(2019) Shannon R. McCurdy et al.   SEMINARS IN HEMATOLOGY

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Posttransplantation cyclophosphamide prevents graft-versus-host disease by inducing alloreactive T cell dysfunction and suppression

(2019) Lucas P. Wachsmuth et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-1+ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer

(2019) Takahiro Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasma exchange eliminates residual mogamulizumab but does not warrant prompt recovery of peripheral Treg levels

(2019) Hiroyuki Sugiura et al.   TRANSFUSION AND APHERESIS SCIENCE

A prospective observational study of immune reconstitution following transplantation with post‐transplant reduced‐dose cyclophosphamide from HLA ‐haploidentical donors

(2019) Hirohisa Nakamae et al.   TRANSPLANT INTERNATIONAL

Loss of Lkb1 impairs Treg function and stability to aggravate graft-versus-host disease after bone marrow transplantation

(2019) Xiuhua Su et al.   Cellular & Molecular Immunology

The role of regulatory T cells in graft-versus-host disease management

(2019) Jennifer S. Whangbo et al.   Expert Review of Hematology

Recommendations for managing PD-1 blockade in the context of allogeneic HCT in Hodgkin lymphoma: taming a necessary evil

(2018) Charles Herbaux et al.   BLOOD

Nivolumab for Relapsed/Refractory Classic Hodgkin Lymphoma After Failure of Autologous Hematopoietic Cell Transplantation: Extended Follow-Up of the Multicohort Single-Arm Phase II CheckMate 205 Trial

(2018) Philippe Armand et al.   JOURNAL OF CLINICAL ONCOLOGY

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Significant Risk of Graft-versus-Host Disease with Exposure to Checkpoint Inhibitors Before and After Allogeneic transplantation

(2018) Awais Ijaz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Anti-CTLA-4 immunotherapy does not deplete FOXP3+ regulatory T cells (Tregs) in human cancers-Letter

(2018) Roberto Ferrara et al.   CLINICAL CANCER RESEARCH

A long-lived IL-2 mutein that selectively activates and expands regulatory T cells as a therapy for autoimmune disease

(2018) Laurence B. Peterson et al.   JOURNAL OF AUTOIMMUNITY

Low-dose interleukin-2 as a modulator of Treg homeostasis after HSCT: current understanding and future perspectives

(2017) Ken-ichi Matsuoka   INTERNATIONAL JOURNAL OF HEMATOLOGY

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pathophysiology of Chronic Graft-versus-Host Disease and Therapeutic Targets

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy, durability, and response predictors of low-dose interleukin-2 therapy for chronic graft-versus-host disease

(2016) John Koreth et al.   BLOOD

A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation

(2016) S. Nikiforow et al.   HAEMATOLOGICA

Pretransplantation Anti-CCR4 Antibody Mogamulizumab Against Adult T-Cell Leukemia/Lymphoma Is Associated With Significantly Increased Risks of Severe and Corticosteroid-Refractory Graft-Versus-Host Disease, Nonrelapse Mortality, and Overall Mortality

(2016) Shigeo Fuji et al.   JOURNAL OF CLINICAL ONCOLOGY

Nivolumab for classical Hodgkin's lymphoma after failure of both autologous stem-cell transplantation and brentuximab vedotin: a multicentre, multicohort, single-arm phase 2 trial

(2016) Anas Younes et al.   LANCET ONCOLOGY

Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model

(2016) Baihao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phase I study of CD25/regulatory T-cell-depleted donor lymphocyte infusion for relapse after allogeneic stem cell transplantation

(2016) S. Nikiforow et al.   HAEMATOLOGICA

Umbilical cord blood-derived T regulatory cells to prevent GVHD: kinetics, toxicity profile, and clinical effect

(2015) C. G. Brunstein et al.   BLOOD

Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD

(2015) A. C. Alho et al.   BLOOD

Adoptive transfer of allogeneic regulatory T cells into patients with chronic graft-versus-host disease

(2015) Anke Theil et al.   CYTOTHERAPY

Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response

(2015) You Jeong Lee et al.   IMMUNITY

PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+T Cells

(2015) Hyo Jin Park et al.   JOURNAL OF IMMUNOLOGY

Donor CD4+ Foxp3+ regulatory T cells are necessary for posttransplantation cyclophosphamide-mediated protection against GVHD in mice

(2014) S. Ganguly et al.   BLOOD

CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells

(2014) D. Schneidawind et al.   BLOOD

Single-agent GVHD prophylaxis with posttransplantation cyclophosphamide after myeloablative, HLA-matched BMT for AML, ALL, and MDS

(2014) C. G. Kanakry et al.   BLOOD

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

(2014) M. F. Martelli et al.   BLOOD

Activity of therapeutic JAK 1/2 blockade in graft-versus-host disease

(2014) S. Spoerl et al.   BLOOD

Increased mitochondrial apoptotic priming of human regulatory T cells after allogeneic hematopoietic stem cell transplantation

(2014) K. Murase et al.   HAEMATOLOGICA

Lineage stability and phenotypic plasticity of Foxp3+regulatory T cells

(2014) Shohei Hori   IMMUNOLOGICAL REVIEWS

Ibrutinib treatment ameliorates murine chronic graft-versus-host disease

(2014) Jason A. Dubovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Multi-Institutional Study of Post-Transplantation Cyclophosphamide As Single-Agent Graft-Versus-Host Disease Prophylaxis After Allogeneic Bone Marrow Transplantation Using Myeloablative Busulfan and Fludarabine Conditioning

(2014) Christopher G. Kanakry et al.   JOURNAL OF CLINICAL ONCOLOGY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

(2013) A. Saha et al.   BLOOD

Thymic Damage, Impaired Negative Selection, and Development of Chronic Graft-versus-Host Disease Caused by Donor CD4+ and CD8+ T Cells

(2013) T. Wu et al.   JOURNAL OF IMMUNOLOGY

Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells

(2013) Wim Pierson et al.   NATURE IMMUNOLOGY

A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application

(2013) Taku Okazaki et al.   NATURE IMMUNOLOGY

Aldehyde Dehydrogenase Expression Drives Human Regulatory T Cell Resistance to Posttransplantation Cyclophosphamide

(2013) C. G. Kanakry et al.   Science Translational Medicine

Low-Dose Interleukin-2 Therapy Restores Regulatory T Cell Homeostasis in Patients with Chronic Graft-Versus-Host Disease

(2013) K.-i. Matsuoka et al.   Science Translational Medicine

STAT3 Transcription Factor Promotes Instability of nTreg Cells and Limits Generation of iTreg Cells during Acute Murine Graft-versus-Host Disease

(2012) Arian Laurence et al.   IMMUNITY

Defucosylated Anti-CCR4 Monoclonal Antibody (KW-0761) for Relapsed Adult T-Cell Leukemia-Lymphoma: A Multicenter Phase II Study

(2012) Takashi Ishida et al.   JOURNAL OF CLINICAL ONCOLOGY

Post-Transplantation Cyclophosphamide for Tolerance Induction in HLA-Haploidentical Bone Marrow Transplantation

(2012) Leo Luznik et al.   SEMINARS IN ONCOLOGY

Prophylactic Effects of Interleukin-2 Receptor Antagonists against Graft-versus-Host Disease Following Unrelated Donor Peripheral Blood Stem Cell Transplantation

(2011) Jun Fang et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Thymic T-cell development in allogeneic stem cell transplantation

(2011) W. Krenger et al.   BLOOD

Low telomerase activity in CD4+ regulatory T cells in patients with severe chronic GVHD after hematopoietic stem cell transplantation

(2011) Y. Kawano et al.   BLOOD

Instability of Foxp3 Expression Limits the Ability of Induced Regulatory T Cells to Mitigate Graft versus Host Disease

(2011) A. Beres et al.   CLINICAL CANCER RESEARCH

High TCR diversity ensures optimal function andhomeostasis of Foxp3+regulatory Tcells

(2011) Lisa Föhse et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Response to self antigen imprints regulatory memory in tissues

(2011) Michael D. Rosenblum et al.   NATURE

Interleukin-2 and Regulatory T Cells in Graft-versus-Host Disease

(2011) John Koreth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Upfront Denileukin Diftitox as in vivo regulatory T-cell depletion in order to enhance vaccination effects in a canine allogeneic hematopoietic stem cell transplantation model

(2011) Anne Knueppel et al.   VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY

Pharmacologic Expansion of Donor-Derived, Naturally Occurring CD4+Foxp3+ Regulatory T Cells Reduces Acute Graft-versus-Host Disease Lethality Without Abrogating the Graft-versus-Leukemia Effect in Murine Models

(2010) Omar Duramad et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease

(2010) L. Luznik et al.   BLOOD

Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics

(2010) C. G. Brunstein et al.   BLOOD

Interleukin-2 Receptor Signaling: At the Interface between Tolerance and Immunity

(2010) Thomas R. Malek et al.   IMMUNITY

Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation

(2010) Ken-ichi Matsuoka et al.   JOURNAL OF CLINICAL INVESTIGATION

Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma

(2010) Kazuhito Yamamoto et al.   JOURNAL OF CLINICAL ONCOLOGY

Raising the NKT cell family

(2010) Dale I Godfrey et al.   NATURE IMMUNOLOGY

Combined CD4+ Donor Lymphocyte Infusion and Low-Dose Recombinant IL-2 Expand FOXP3+ Regulatory T Cells following Allogeneic Hematopoietic Stem Cell Transplantation

(2009) Emmanuel Zorn et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Fatal Hyperacute Graft-versus-Host Disease following Denileukin Diftitox Treatment for Recurrent T Cell Lymphoma after Allogeneic Stem Cell Transplantation

(2009) Sapna Khubchandani et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease

(2009) A. B. Pillai et al.   BLOOD

First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127− T regulatory cells

(2009) Piotr Trzonkowski et al.   CLINICAL IMMUNOLOGY

CD4 + CD25 + Foxp3 + T Regulatory Cells with Limited TCR Diversity in Control of Autoimmunity

(2009) Dennis Adeegbe et al.   JOURNAL OF IMMUNOLOGY

Graft-versus-host disease

(2009) James LM Ferrara et al.   LANCET

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT

(2008) A. L. Bayer et al.   BLOOD

Regulatory T Cells and Immune Tolerance

(2008) Shimon Sakaguchi et al.   CELL

Alpha-galactosylceramide-driven immunotherapy for allergy

(2008) Yasuyuki Ishii   Frontiers in Bioscience-Landmark

Homeostasis of Naive and Memory T Cells

(2008) Charles D. Surh et al.   IMMUNITY