Microfluidic characterization of single‐cell biophysical properties and the applications in cancer diagnosis

Highly efficient mRNA delivery with nonlinear microfluidic cell stretching for cellular engineering

(2023) Chan Kwon et al.   LAB ON A CHIP

Machine learning empowered multi-stress level electromechanical phenotyping for high-dimensional single cell analysis

(2023) Minhui Liang et al.   BIOSENSORS & BIOELECTRONICS

Modified Red Blood Cells as Multimodal Standards for Benchmarking Single-Cell Cytometry and Separation Based on Electrical Physiology

(2022) Armita Salahi et al.   ANALYTICAL CHEMISTRY

Robotic automation of droplet microfluidics

(2022) Tuan M. Tran et al.   Biomicrofluidics

Size and density measurements of single sickle red blood cells using microfluidic magnetic levitation

(2022) Utku Goreke et al.   LAB ON A CHIP

Physical Cytometry: Detecting Mass-Related Properties of Single Cells

(2022) Yuliang Zhao et al.   ACS Sensors

Interpretation of cell mechanical experiments in microfluidic systems depend on the choice of cellular shape descriptors

(2022) Bob Fregin et al.   Biomicrofluidics

Development of Microfluidic System Enabling High-Throughput Characterization of Multiple Biophysical Parameters of Single Cells

(2022) Ke Wang et al.   IEEE TRANSACTIONS ON ELECTRON DEVICES

Effect of the mechanical properties of the cell membrane on the transition energy barrier of electroporation

(2022) Yan Mi et al.   JOURNAL OF APPLIED PHYSICS

Cellular biomechanics: Fluid-structure interaction or structural simulation?

(2022) L. Papadakis et al.   JOURNAL OF BIOMECHANICS

Microfluidic Impedance‐Deformability Cytometry for Label‐Free Single Neutrophil Mechanophenotyping

(2022) Chayakorn Petchakup et al.   Small

Application of Microfluidics in Detection of Circulating Tumor Cells

(2022) Can Li et al.   Frontiers in Bioengineering and Biotechnology

Impedance‐Enabled Camera‐Free Intrinsic Mechanical Cytometry

(2022) Yongxiang Feng et al.   Small Methods

Automated measurement of cell mechanical properties using an integrated dielectrophoretic microfluidic device

(2022) Hao Yang et al.   iScience

Measurement of dielectric properties of cells at single-cell resolution using electrorotation

(2022) Yuwen Li et al.   BIOMEDICAL MICRODEVICES

Single-cell assessment of the modulation of macrophage activation by ex vivo intervertebral discs using impedance cytometry

(2022) Armita Salahi et al.   BIOSENSORS & BIOELECTRONICS

High-resolution mass measurements of single budding yeast reveal linear growth segments

(2022) Andreas P. Cuny et al.   Nature Communications

A systematic study of size correlation and Young's modulus sensitivity for cellular mechanical phenotyping by microfluidic approaches

(2022) Minhui Liang et al.   Advanced Healthcare Materials

Universal and Sensitive Drug Assessment Biosensing Platform Using Optimal Mechanical Beating Detection of Single Cardiomyocyte

(2022) Dongxin Xu et al.   ACS Nano

Human cancer cells generate spontaneous calcium transients and intercellular waves that modulate tumor growth

(2022) Chenyu Liang et al.   BIOMATERIALS

Parallel Impedance Cytometry for Real-Time Screening of Bacterial Single Cells from Nano- to Microscale

(2022) Tao Tang et al.   ACS Sensors

Extensional-Flow Impedance Cytometer for Contactless and Optics-Free Erythrocyte Deformability Analysis

(2022) Riccardo Reale et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Machine learning-based impedance system for real-time recognition of antibiotic-susceptible bacteria with parallel cytometry

(2022) Tao Tang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Label-Free Multivariate Biophysical Phenotyping-Activated Acoustic Sorting at the Single-Cell Level

(2021) Peixian Li et al.   ANALYTICAL CHEMISTRY

Single-Cell Stretching in Viscoelastic Fluids with Electronically Triggered Imaging for Cellular Mechanical Phenotyping

(2021) Minhui Liang et al.   ANALYTICAL CHEMISTRY

A constriction channel analysis of astrocytoma stiffness and disease progression

(2021) P. M. Graybill et al.   Biomicrofluidics

Necroptosis, pyroptosis and apoptosis: an intricate game of cell death

(2021) Damien Bertheloot et al.   Cellular & Molecular Immunology

Direct and Label‐Free Cell Status Monitoring of Spheroids and Microcarriers Using Microfluidic Impedance Cytometry

(2021) Lingyan Gong et al.   Small

Microfluidic Integration for Electrochemical Biosensor Applications

(2021) Leona M. Schmidt-Speicher et al.   Current Opinion in Electrochemistry

Circular shaped microelectrodes for single cell electrical measurements for lab-on-a-chip applications

(2021) Amina Farooq et al.   BIOMEDICAL MICRODEVICES

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models in vitro

(2021) Thomas Collins et al.   Biomicrofluidics

Cell cycle control in cancer

(2021) Helen K. Matthews et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential

(2021) Stefanie Fuchs et al.   ACS Biomaterials-Science & Engineering

Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma

(2021) Assaf Zaritsky et al.   Cell Systems

High-Throughput Characterization of Cell Adhesion Strength Using Long-Channel Constriction-Based Microfluidics

(2021) Mingji Wei et al.   ACS Sensors

Selective Single-Cell Sorting Using a Multisectorial Electroactive Nanowell Platform

(2021) Lukas Menze et al.   ACS Nano

Label-Free Cancer Stem-like Cell Assay Conducted at a Single Cell Level Using Microfluidic Mechanotyping Devices

(2021) Miyu Terada et al.   ANALYTICAL CHEMISTRY

Ca2+ roles in electroporation-induced changes of cancer cell physiology: From membrane repair to cell death

(2021) Diana Navickaitė et al.   BIOELECTROCHEMISTRY

Microscopic impedance cytometry for quantifying single cell shape

(2021) Tao Tang et al.   BIOSENSORS & BIOELECTRONICS

Optimisation of an Electrical Impedance Sensor for Use in Microfluidic Chip Electrophoresis

(2021) Martin Hantschke et al.   IEEE SENSORS JOURNAL

Dual-frequency impedance assays for intracellular components in microalgal cells

(2021) Tao Tang et al.   LAB ON A CHIP

Neural network-enhanced real-time impedance flow cytometry for single-cell intrinsic characterization

(2021) Yongxiang Feng et al.   LAB ON A CHIP

Label-free mechanoelectrical investigation of single cancer cells by dielectrophoretic-induced stretch assay

(2021) Shahriar Shalileh et al.   SENSORS AND ACTUATORS B-CHEMICAL

Microfluidic impedance cytometry for single-cell sensing: Review on electrode configurations

(2021) Shu Zhu et al.   TALANTA

Functional drug susceptibility testing using single-cell mass predicts treatment outcome in patient-derived cancer neurosphere models

(2021) Max A. Stockslager et al.   Cell Reports

Recent Advances in Electrical Impedance Sensing Technology for Single-Cell Analysis

(2021) Zhao Zhang et al.   Biosensors-Basel

A Review of Advanced Impedance Biosensors with Microfluidic Chips for Single-Cell Analysis

(2021) Soojung Kim et al.   Biosensors-Basel

A neural network approach for real-time particle/cell characterization in microfluidic impedance cytometry

(2020) Carlos Honrado et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Automated Parallel Electrical Characterization of Cells Using Optically-Induced Dielectrophoresis

(2020) Na Liu et al.   IEEE Transactions on Automation Science and Engineering

Construction of a human cell landscape at single-cell level

(2020) Xiaoping Han et al.   NATURE

A comparison of microfluidic methods for high-throughput cell deformability measurements

(2020) Marta Urbanska et al.   NATURE METHODS

Strategies for enrichment of circulating tumor cells

(2020) Xinchun Li et al.   Translational Cancer Research

Nanocytometer for smart analysis of peripheral blood and acute myeloid leukemia: a pilot study

(2020) Julian Schuett et al.   NANO LETTERS

Dielectrophoretic manipulation of cancer cells and their electrical characterization

(2020) Ina Turcan et al.   ACS Combinatorial Science

Simultaneous time-varying viscosity, elasticity, and mass measurements of single adherent cancer cells across cell cycle

(2020) Olaoluwa O. Adeniba et al.   Scientific Reports

Label-Free and Simultaneous Mechanical and Electrical Characterization of Single Plant Cells Using Microfluidic Impedance Flow Cytometry

(2020) Ziyu Han et al.   ANALYTICAL CHEMISTRY

Mechanical properties of single cells: Measurement methods and applications

(2020) Yansheng Hao et al.   BIOTECHNOLOGY ADVANCES

Micro/Nano fabricated cantilever based biosensor platform: A review and recent progress

(2020) Aviru Kumar Basu et al.   ENZYME AND MICROBIAL TECHNOLOGY

Analysis on reversible/irreversible electroporation region in lung adenocarcinoma cell model in vitro with electric pulses delivered by needle electrodes

(2020) Yanpeng Lv et al.   PHYSICS IN MEDICINE AND BIOLOGY

Electrical Impedance Spectroscopy for Monitoring Chemoresistance of Cancer Cells

(2020) Lexi Crowell et al.   Micromachines

Actin networks regulate the cell membrane permeability during electroporation

(2020) Aswin Muralidharan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

A microdevice platform for characterizing the effect of mechanical strain magnitudes on the maturation of iPSC-Cardiomyocytes

(2020) Wenkun Dou et al.   BIOSENSORS & BIOELECTRONICS

Electrorotation of single microalgae cells during lipid accumulation for assessing cellular dielectric properties and total lipid contents

(2020) Yu-Sheng Lin et al.   BIOSENSORS & BIOELECTRONICS

Portable Automatic Microring Resonator System Using a Subwavelength Grating Metamaterial Waveguide for High-Sensitivity Real-Time Optical-Biosensing Applications

(2020) Varun Soni et al.   IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING

Advances in micropipette aspiration: applications in cell biomechanics, models and extended studies

(2019) Blanca González-Bermúdez et al.   BIOPHYSICAL JOURNAL

A Microfluidic Micropipette Aspiration Device to Study Single-Cell Mechanics Inspired by the Principle of Wheatstone Bridge

(2019) Yong-Jiang Li et al.   Micromachines

Microfluidic Single-Cell Manipulation and Analysis: Methods and Applications

(2019) Tao Luo et al.   Micromachines

Biophysical properties of cells for cancer diagnosis

(2019) Sharda Yadav et al.   JOURNAL OF BIOMECHANICS

Cells Under Stress: An Inertial-Shear Microfluidic Determination of Cell Behavior

(2019) Fern J. Armistead et al.   BIOPHYSICAL JOURNAL

Biophysical phenotyping of single cells using a differential multiconstriction microfluidic device with self-aligned 3D electrodes

(2019) Dahou Yang et al.   BIOSENSORS & BIOELECTRONICS

On‐chip technology for single‐cell arraying, electrorotation‐based analysis and selective release

(2019) Kevin Keim et al.   ELECTROPHORESIS

Microfluidic multiple cross-correlated Coulter counter for improved particle size analysis

(2019) Wenchang Zhang et al.   SENSORS AND ACTUATORS B-CHEMICAL

Biophysical phenotyping of cells via impedance spectroscopy in parallel cyclic deformability channels

(2019) Xiang Ren et al.   Biomicrofluidics

Toward Microfluidic Label‐Free Isolation and Enumeration of Circulating Tumor Cells from Blood Samples

(2019) Camille Raillon et al.   CYTOMETRY PART A

High-Throughput, Time-Resolved Mechanical Phenotyping of Prostate Cancer Cells

(2019) Yuri Belotti et al.   Scientific Reports

Toward point-of-care assessment of patient response: a portable tool for rapidly assessing cancer drug efficacy using multifrequency impedance cytometry and supervised machine learning

(2019) Karan Ahuja et al.   Microsystems & Nanoengineering

A novel impedance sensing approach for precise electromechanical characterization of cells

(2019) Karthik Mahesh et al.   JOURNAL OF MICROMECHANICS AND MICROENGINEERING

Particle Self-Aligning, Focusing, and Electric Impedance Microcytometer Device for Label-Free Single Cell Morphology Discrimination and Yeast Budding Analysis

(2019) Xinwu Xie et al.   ANALYTICAL CHEMISTRY

A Microfluidic Device Integrating Impedance Flow Cytometry and Electric Impedance Spectroscopy for High-Efficiency Single-Cell Electrical Property Measurement

(2019) Yongxiang Feng et al.   ANALYTICAL CHEMISTRY

The Extracellular, Cellular, and Nuclear Stiffness, a Trinity in the Cancer Resistome—A Review

(2019) Sara Sofia Deville et al.   Frontiers in Oncology

Electrical Impedance Measurements of Biological Cells in Response to External Stimuli

(2018) Amin Mansoorifar et al.   ANALYTICAL CHEMISTRY

Electrodeformation-Based Biomechanical Chip for Quantifying Global Viscoelasticity of Cancer Cells Regulated by Cell Cycle

(2018) Yao Teng et al.   ANALYTICAL CHEMISTRY

Seeing More: A Future of Augmented Microscopy

(2018) Devin P. Sullivan et al.   CELL

Differentiation Between Normal and Cancerous Human Urothelial Cell Lines Using Micro-Electrical Impedance Spectroscopy at Multiple Frequencies

(2018) Hyeon Woo Kim et al.   Journal of Medical and Biological Engineering

3D cell electrorotation and imaging for measuring multiple cellular biophysical properties

(2018) Liang Huang et al.   LAB ON A CHIP

Lab-on-a-Chip Platforms for Biophysical Studies of Cancer with Single-Cell Resolution

(2018) Vasudha C. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Microfluidic cell sorting by stiffness to examine heterogenic responses of cancer cells to chemotherapy

(2018) Muhymin Islam et al.   Cell Death & Disease

Entry and passage behavior of biological cells in a constricted compliant microchannel

(2018) A. Raj et al.   RSC Advances

Characterizing cellular mechanical phenotypes with mechano-node-pore sensing

(2018) Junghyun Kim et al.   Microsystems & Nanoengineering

Understanding flow dynamics, viability and metastatic potency of cervical cancer (HeLa) cells through constricted microchannel

(2018) Binita Nath et al.   Scientific Reports

Actin cytoskeleton stiffness grades metastatic potential of ovarian carcinoma Hey A8 cells via nanoindentation mapping

(2017) Z.L. Zhou et al.   JOURNAL OF BIOMECHANICS

A combined experimental and theoretical approach towards mechanophenotyping of biological cells using a constricted microchannel

(2017) A. Raj et al.   LAB ON A CHIP

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Measuring Cell Viscoelastic Properties Using a Microfluidic Extensional Flow Device

(2016) Lionel Guillou et al.   BIOPHYSICAL JOURNAL

The physical origins of transit time measurements for rapid, single cell mechanotyping

(2016) Kendra D. Nyberg et al.   LAB ON A CHIP

Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate

(2016) Mark M Stevens et al.   NATURE BIOTECHNOLOGY

A Comprehensive Review of Optical Stretcher for Cell Mechanical Characterization at Single-Cell Level

(2016) Tie Yang et al.   Micromachines

Differential microfluidic sensor on printed circuit board for biological cells analysis

(2015) Dongyuan Shi et al.   ELECTROPHORESIS

Microfluidic Impedance Flow Cytometry Enabling High-Throughput Single-Cell Electrical Property Characterization

(2015) Jian Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis

(2015) Sungmin Son et al.   JOURNAL OF CELL BIOLOGY

Real-time deformability cytometry: on-the-fly cell mechanical phenotyping

(2015) Oliver Otto et al.   NATURE METHODS

Classification of Cells with Membrane Staining and/or Fixation Based on Cellular Specific Membrane Capacitance and Cytoplasm Conductivity

(2015) Song-Bin Huang et al.   Micromachines

Microfluidic impedance cytometry of tumour cells in blood

(2014) Daniel Spencer et al.   Biomicrofluidics

An Engineered Membrane to Measure Electroporation: Effect of Tethers and Bioelectronic Interface

(2014) William Hoiles et al.   BIOPHYSICAL JOURNAL

Characterization of Dielectric Responses of Human Cancer Cells in the Terahertz Region

(2014) Keiichiro Shiraga et al.   Journal of Infrared Millimeter and Terahertz Waves

A nonlinear electromechanical coupling model for electropore expansion in cell electroporation

(2014) Peigang Deng et al.   JOURNAL OF PHYSICS D-APPLIED PHYSICS

Red blood cell fatigue evaluation based on the close-encountering point between extensibility and recoverability

(2014) Shinya Sakuma et al.   LAB ON A CHIP

Recent advances in the development of single cell analysis—A review

(2013) Karel Klepárník et al.   ANALYTICA CHIMICA ACTA

Microfluidic Chip with Integrated Electrical Cell-Impedance Sensing for Monitoring Single Cancer Cell Migration in Three-Dimensional Matrixes

(2013) Tien Anh Nguyen et al.   ANALYTICAL CHEMISTRY

Mechanobiology and Developmental Control

(2013) Tadanori Mammoto et al.   Annual Review of Cell and Developmental Biology

A label-free DC impedance-based microcytometer for circulating rare cancer cell counting

(2013) Hyoungseon Choi et al.   LAB ON A CHIP

Characterizing deformability and surface friction of cancer cells

(2013) S. Byun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monitoring cellular activities of cancer cells using impedance sensing devices

(2013) Rangadhar Pradhan et al.   SENSORS AND ACTUATORS B-CHEMICAL

Microfluidics-Based Assessment of Cell Deformability

(2012) Andrea Adamo et al.   ANALYTICAL CHEMISTRY

Direct observation of mammalian cell growth and size regulation

(2012) Sungmin Son et al.   NATURE METHODS

Linear and Nonlinear Rheology of Living Cells

(2011) Philip Kollmannsberger et al.   Annual Review of Materials Research

Cell adhesion in embryo morphogenesis

(2011) Vanessa Barone et al.   CURRENT OPINION IN CELL BIOLOGY

Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network

(2011) Ning Bao et al.   LAB ON A CHIP

On-chip measurements of cell compressibility via acoustic radiation

(2011) Deny Hartono et al.   LAB ON A CHIP

The role of physiological heterogeneity in microbial population behavior

(2010) Mary E Lidstrom et al.   Nature Chemical Biology

The influence of different membrane components on the electrical stability of bilayer lipid membranes

(2009) Iris van Uitert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Microfluidic Electroporative Flow Cytometry for Studying Single-Cell Biomechanics

(2008) Ning Bao et al.   ANALYTICAL CHEMISTRY