Journal
JOURNAL OF INFRARED MILLIMETER AND TERAHERTZ WAVES
Volume 35, Issue 5, Pages 493-502Publisher
SPRINGER
DOI: 10.1007/s10762-014-0067-y
Keywords
Terahertz time-domain attenuated total reflection (THz TD-ATR) spectroscopy; complex dielectric constant; intracellularwater; cancer cells; Debye-Lorentz fitting
Funding
- Industry-Academia Collaborative R&D from Japan Science and Technology Agency (JST)
- Grants-in-Aid for Scientific Research [14J00295] Funding Source: KAKEN
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Terahertz time-domain attenuated total reflection spectroscopy, in combination with a two-interface model, is used to determine the complex dielectric constants of cultured human cancer cells (DLD-1, HEK293 and HeLa). Picosecond and sub-picosecond water dynamics are dominant in the measured complex dielectric constants of these cells. We demonstrate that dielectric responses below 1.0 THz best characterize the particular water dynamics of cancer cells when compared with extracellular water. Debye-Lorentz fitting revealed that this is due to a significantly attenuated slow relaxation mode and enhanced fast relaxation mode of the water in these cancer cells. These findings could lead to a new procedure to digitally evaluate cellular activities or functions, in terms of intracellular water dynamics, and remove the veil from the mysterious intracellular milieu.
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