Journal
BIOMICROFLUIDICS
Volume 16, Issue 1, Pages -Publisher
AIP Publishing
DOI: 10.1063/5.0064265
Keywords
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Categories
Funding
- National Science Foundation CAREER Award [DBI-1253293]
- National Institutes of Health (NIH) [R01-EB019453, R01-HG008978, R21-HG007233, DP2-AR068129, R21-AI116218]
- Defense Advanced Research Projects Agency Living Foundries Program [HR0011-12-C-0065, N66001-12-C-4211, HR0011-12-C-0066]
- Fold F(x) Program [DE-AC02-05CH11231]
- Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy
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This study demonstrates the automation of droplet microfluidics using commercial fluid-handling robotics, which speeds up the integration of these methods into biological workflows by utilizing the robot's capabilities such as thermal control, incubation, and plate scanning.
Droplet microfluidics enables powerful analytic capabilities but often requires workflows involving macro- and microfluidic processing steps that are cumbersome to perform manually. Here, we demonstrate the automation of droplet microfluidics with commercial fluid-handling robotics. The workflows incorporate common microfluidic devices including droplet generators, mergers, and sorters and utilize the robot's native capabilities for thermal control, incubation, and plate scanning. The ability to automate microfluidic devices using commercial fluid handling will speed up the integration of these methods into biological workflows.
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