How to fix DNA breaks: new insights into the mechanism of non-homologous end joining

DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism

(2023) Wei‐Min Chen et al.   EMBO JOURNAL

Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining

(2023) Christopher J. Buehl et al.   MOLECULAR CELL

Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ

(2023) Steven W. Hardwick et al.   STRUCTURE

Strategies for precise gene edits in mammalian cells

(2023) Katye M. Fichter et al.   Molecular Therapy-Nucleic Acids

Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ

(2023) Siyu Chen et al.   Science Advances

Structure and function of the apical PIKKs in double-strand break repair

(2023) Jingfei Xu et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structure and mechanism in non-homologous end joining

(2023) Alex Vogt et al.   DNA REPAIR

A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration Resistant Prostate Cancer

(2022) Emanuela Dylgjeri et al.   CLINICAL CANCER RESEARCH

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

(2022) Shikang Liang et al.   NATURE

Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks

(2022) Go Watanabe et al.   JOURNAL OF MOLECULAR BIOLOGY

The active DNA-PK holoenzyme occupies a tensed state in a staggered synaptic complex

(2021) Morgan Hepburn et al.   STRUCTURE

SAP domain forms a flexible part of DNA aperture in Ku70/80

(2021) Aleš Hnízda et al.   FEBS Journal

Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

(2021) Lan Liu et al.   MOLECULAR CELL

DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis

(2020) Zhengping Shao et al.   NATURE

Polymerase μ in non-homologous DNA end joining: importance of the order of arrival at a double-strand break in a purified system

(2020) Bailin Zhao et al.   NUCLEIC ACIDS RESEARCH

Biomarker-Guided Development of DNA Repair Inhibitors

(2020) James M. Cleary et al.   MOLECULAR CELL

The recent advances in non-homologous end-joining through the lens of lymphocyte development

(2020) Xiaobin S. Wang et al.   DNA REPAIR

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Uncovering DNA-PKcs ancient phylogeny, unique sequence motifs and insights for human disease

(2020) James P. Lees-Miller et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Plugged into the Ku-DNA hub: The NHEJ network

(2019) Philippe Frit et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

New insights into the evolutionary conservation of the sole PIKK pseudokinase Tra1/TRRAP

(2019) Alberto Elías-Villalobos et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The role of DNA-PK in aging and energy metabolism

(2018) Jay H. Chung   FEBS Journal

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dissection of DNA double-strand-break repair using novel single-molecule forceps

(2018) Jing L. Wang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A single XLF dimer bridges DNA ends during nonhomologous end joining

(2018) Thomas G. W. Graham et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Structures of closed and open conformations of dimeric human ATM

(2017) Domagoj Baretić et al.   Science Advances

Structure of the human dimeric ATM kinase

(2016) Wilson C. Y. Lau et al.   CELL CYCLE

End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

(2016) Vijay Menon et al.   DNA REPAIR

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

(2016) Thomas G.W. Graham et al.   MOLECULAR CELL

The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins

(2016) Gabrielle J. Grundy et al.   Nature Communications

WRN regulates pathway choice between classical and alternative non-homologous end joining

(2016) Raghavendra A. Shamanna et al.   Nature Communications

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

(2015) Jonathan F. Goodwin et al.   CANCER CELL

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

(2015) Nicholas Jette et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structural insights into NHEJ: Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time

(2014) Gareth J. Williams et al.   DNA REPAIR

Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation

(2014) J. A. Neal et al.   MOLECULAR AND CELLULAR BIOLOGY

DNA polymerases in nonhomologous end joining: Are there any benefits to standing out from the crowd?

(2012) Dale A. Ramsden et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

(2012) Takashi Ochi et al.   STRUCTURE

Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining

(2012) Pablo De Ioannes et al.   Cell Reports

Live cell imaging of XLF and XRCC4 reveals a novel view of protein assembly in the non-homologous end-joining pathway

(2011) Ken-ichi Yano et al.   CELL CYCLE

Involvement of DNA-dependent Protein Kinase in Normal Cell Cycle Progression through Mitosis

(2011) Kyung-Jong Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair

(2011) Michael Weinfeld et al.   TRENDS IN BIOCHEMICAL SCIENCES

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

Protein Phosphatase 6 Interacts with the DNA-Dependent Protein Kinase Catalytic Subunit and Dephosphorylates  -H2AX

(2010) P. Douglas et al.   MOLECULAR AND CELLULAR BIOLOGY

Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining

(2009) Brandi L. Mahaney et al.   BIOCHEMICAL JOURNAL

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE

Mechanism of Eukaryotic Homologous Recombination

(2008) Joseph San Filippo et al.   Annual Review of Biochemistry

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation

(2008) Enriqueta Riballo et al.   NUCLEIC ACIDS RESEARCH