Two distinct long-range synaptic complexes promote different aspects of end processing prior to repair of DNA breaks by non-homologous end joining

Human topoisomerases and their roles in genome stability and organization

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Poly(ADP) ribose polymerase promotes DNA polymerase theta-mediated end joining by activation of end resection

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Catalytically inactive DNA ligase IV promotes DNA repair in living cells

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Structure of an activated DNA-PK and its implications for NHEJ

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Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

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Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

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DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP

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Activation of DNA-PK by hairpinned DNA ends reveals a stepwise mechanism of kinase activation

(2020) Katheryn Meek   NUCLEIC ACIDS RESEARCH

Untangling trapped topoisomerases with tyrosyl-DNA phosphodiesterases

(2020) Guido Zagnoli-Vieira et al.   DNA REPAIR

Deciphering the role of distinct DNA-PK phosphorylations at collapsed replication forks

(2020) Jessica A. Neal et al.   DNA REPAIR

Dimers of DNA-PK create a stage for DNA double-strand break repair

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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

(2019) Gabriel Balmus et al.   Nature Communications

Plugged into the Ku-DNA hub: The NHEJ network

(2019) Philippe Frit et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structural insights into the critical DNA damage sensors DNA-PKcs, ATM and ATR

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The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

(2019) Bailin Zhao et al.   Nature Communications

A Mechanism to Minimize Errors during Non-homologous End Joining

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Dissection of DNA double-strand-break repair using novel single-molecule forceps

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Dissection of DNA double-strand-break repair using novel single-molecule forceps

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XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining

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Nonhomologous DNA end-joining for repair of DNA double-strand breaks

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Non-homologous DNA end joining and alternative pathways to double-strand break repair

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Tyrosyl–DNA phosphodiesterases: rescuing the genome from the risks of relaxation

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Cryo-EM structure of the DNA-PK holoenzyme

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DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

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End-processing nucleases and phosphodiesterases: An elite supporting cast for the non-homologous end joining pathway of DNA double-strand break repair

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Restoration of ATM Expression in DNA-PKcs–Deficient Cells Inhibits Signal End Joining

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Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

(2016) Nguyen Ngoc Hoa et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

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Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry

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XRCC4/XLF Interaction Is Variably Required for DNA Repair and Is Not Required for Ligase IV Stimulation

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Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation

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Differential Radiosensitivity Phenotypes of DNA-PKcs Mutations Affecting NHEJ and HRR Systems following Irradiation with Gamma-Rays or Very Low Fluences of Alpha Particles

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The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

(2014) Crystal A. Waters et al.   Nature Communications

A noncatalytic function of the ligation complex during nonhomologous end joining

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PRKDC mutations in a SCID patient with profound neurological abnormalities

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RNA-Guided Human Genome Engineering via Cas9

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TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

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Tyrosyl DNA phosphodiesterase 2, an enzyme fit for purpose

(2012) Keith W. Caldecott   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation

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Delineation of the Xrcc4-interacting Region in the Globular Head Domain of Cernunnos/XLF

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H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes

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Tyrosyl-DNA phosphodiesterase and the repair of 3′-phosphoglycolate-terminated DNA double-strand breaks

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Roles for NBS1 in Alternative Nonhomologous End-Joining of V(D)J Recombination Intermediates

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The Ku80 Carboxy Terminus Stimulates Joining and Artemis-Mediated Processing of DNA Ends

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A Biochemically Defined System for Coding Joint Formation in V(D)J Recombination

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