The role of DNA-PK in aging and energy metabolism

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Non-homologous DNA end joining and alternative pathways to double-strand break repair

(2017) Howard H. Y. Chang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB

(2017) Leen Catrysse et al.   TRENDS IN CELL BIOLOGY

Rodent models for resolving extremes of exercise and health

(2016) Fleur C. Garton et al.   PHYSIOLOGICAL GENOMICS

Aging and DNA damage in humans: a meta-analysis study

(2016) Jorge Pinto Soares et al.   Aging-US

DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair

(2015) S. Ying et al.   CANCER RESEARCH

DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4+ T-cell function without causing severe combined immunodeficiency

(2015) Mohamed A. Ghonim et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The metabolic regulation of aging

(2015) Toren Finkel   NATURE MEDICINE

The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

(2015) Nicholas Jette et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Dendritic cells induce Th2-mediated airway inflammatory responses to house dust mite via DNA-dependent protein kinase

(2015) Amarjit Mishra et al.   Nature Communications

It is time to classify biological aging as a disease

(2015) Sven Bulterijs et al.   Frontiers in Genetics

Aging: not all DNA damage is equal

(2014) Wilbert P Vermeij et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe

(2014) Amanda K. Ashley et al.   DNA REPAIR

The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair

(2014) Mengxia Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases

(2014) C. Franceschi et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Rapamycin extends murine lifespan but has limited effects on aging

(2013) Frauke Neff et al.   JOURNAL OF CLINICAL INVESTIGATION

AMPK, insulin resistance, and the metabolic syndrome

(2013) Neil B. Ruderman et al.   JOURNAL OF CLINICAL INVESTIGATION

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Increased Mammalian Lifespan and a Segmental and Tissue-Specific Slowing of Aging after Genetic Reduction of mTOR Expression

(2013) J. Julie Wu et al.   Cell Reports

A role of DNA-dependent protein kinase for the activation of AMP-activated protein kinase in response to glucose deprivation

(2012) Parmeshwar Narayan Amatya et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Diabetes in Older Adults

(2012) M. S. Kirkman et al.   DIABETES CARE

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Heat Shock Protein 90α (Hsp90α) Is Phosphorylated in Response to DNA Damage and Accumulates in Repair Foci

(2012) Maria Quanz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA damage checkpoints in stem cells, ageing and cancer

(2012) Tobias Sperka et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress

(2012) S. Liu et al.   NUCLEIC ACIDS RESEARCH

Heat shock protein 90  (HSP90 ), a substrate and chaperone of DNA-PK necessary for the apoptotic response

(2012) S. Solier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Rat Model System to Study Complex Disease Risks, Fitness, Aging, and Longevity

(2012) Lauren Gerard Koch et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

AMP-activated protein kinase (AMPK)  1 2 muscle null mice reveal an essential role for AMPK in maintaining mitochondrial content and glucose uptake during exercise

(2011) H. M. O'Neill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted Expression of Catalase to Mitochondria Prevents Age-Associated Reductions in Mitochondrial Function and Insulin Resistance

(2010) Hui-Young Lee et al.   Cell Metabolism

Alterations in Skeletal Muscle Fatty Acid Handling Predisposes Middle-Aged Mice to Diet-Induced Insulin Resistance

(2010) D. P. Y. Koonen et al.   DIABETES

Phosphorylation of p50 NF-κB at a Single Serine Residue by DNA-dependent Protein Kinase Is Critical for VCAM-1 Expression upon TNF Treatment

(2010) Jihang Ju et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Hsp90 prevents phenotypic variation by suppressing the mutagenic activity of transposons

(2010) Valeria Specchia et al.   NATURE

The impact of sarcopenia and exercise training on skeletal muscle satellite cells

(2009) Tim Snijders et al.   AGEING RESEARCH REVIEWS

Delayed kinetics of DNA double-strand break processing in normal and pathological aging

(2009) Olga A. Sedelnikova et al.   AGING CELL

A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin

(2009) Roger H.F. Wong et al.   CELL

Insulin/IGF-1 paradox of aging: Regulation via AKT/IKK/NF-κB signaling

(2009) Antero Salminen et al.   CELLULAR SIGNALLING

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif

(2009) Jongsun Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

(2009) David E. Harrison et al.   NATURE

Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance

(2008) Muhammad A. Abdul-Ghani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Born to run; the story of the PEPCK-Cmus mouse

(2008) Richard W. Hanson et al.   BIOCHIMIE

AMPK and PPARδ Agonists Are Exercise Mimetics

(2008) Vihang A. Narkar et al.   CELL

Muscle-Specific IRS-1 Ser->Ala Transgenic Mice Are Protected From Fat-Induced Insulin Resistance in Skeletal Muscle

(2008) K. Morino et al.   DIABETES

In VivoAnalysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

(2008) Banu Surucu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells

(2008) B. L. Ruis et al.   MOLECULAR AND CELLULAR BIOLOGY

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

(2008) Lana Bozulic et al.   MOLECULAR CELL

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

(2008) E. Huston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 stabilization in response to DNA damage requires Akt/PKB and DNA-PK

(2008) K. A. Boehme et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA