Dissection of DNA double-strand-break repair using novel single-molecule forceps

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Synthetic lethality between PAXX and XLF in mammalian development

(2016) Gabriel Balmus et al.   GENES & DEVELOPMENT

An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex

(2016) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sliding sleeves of XRCC4–XLF bridge DNA and connect fragments of broken DNA

(2016) Ineke Brouwer et al.   NATURE

Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

(2016) Susan P Lees-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Achieving selectivity in space and time with DNA double-strand-break response and repair: molecular stages and scaffolds come with strings attached

(2016) S. Liang et al.   STRUCTURAL CHEMISTRY

Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer

(2016) Susan P Lees-Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PAXX Is an Accessory c-NHEJ Factor that Associates with Ku70 and Has Overlapping Functions with XLF

(2016) Satish K. Tadi et al.   Cell Reports

Mutations in the NHEJ Component XRCC4 Cause Primordial Dwarfism

(2015) Jennie E. Murray et al.   AMERICAN JOURNAL OF HUMAN GENETICS

XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair

(2015) A Craxton et al.   CELL DEATH AND DIFFERENTIATION

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

(2015) Wenxia Jiang et al.   MOLECULAR CELL

A dynamic DNA-repair complex observed by correlative single-molecule nanomanipulation and fluorescence

(2015) Evan T Graves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

(2015) T. Ochi et al.   SCIENCE

A dynamic DNA-repair complex observed by correlative single-molecule nanomanipulation and fluorescence

(2015) Evan T Graves et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Non-homologous end-joining partners in a helical dance: structural studies of XLF–XRCC4 interactions

(2012) Qian Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

(2012) Brandi L. Mahaney et al.   Biochemistry and Cell Biology

A human XRCC4–XLF complex bridges DNA

(2012) Sara N. Andres et al.   NUCLEIC ACIDS RESEARCH

Structural Insights into the Role of Domain Flexibility in Human DNA Ligase IV

(2012) Takashi Ochi et al.   STRUCTURE

XRCC4 Protein Interactions with XRCC4-like Factor (XLF) Create an Extended Grooved Scaffold for DNA Ligation and Double Strand Break Repair

(2011) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining

(2011) V. Ropars et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

XLF Regulates Filament Architecture of the XRCC4·Ligase IV Complex

(2010) Michal Hammel et al.   STRUCTURE

Ku and DNA-dependent Protein Kinase Dynamic Conformations and Assembly Regulate DNA Binding and the Initial Non-homologous End Joining Complex

(2009) Michal Hammel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats

(2009) Bancinyane L. Sibanda et al.   NATURE