Dynamics of the Artemis and DNA-PKcs Complex in the Repair of Double-Strand Breaks

Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs

(2022) Shikang Liang et al.   NATURE

Physical ARTEMIS:DNA-PKcs interaction is necessary for V(D)J recombination

(2022) Doris Niewolik et al.   NUCLEIC ACIDS RESEARCH

Structural analysis of the basal state of the Artemis:DNA-PKcs complex

(2022) Go Watanabe et al.   NUCLEIC ACIDS RESEARCH

Structural basis of long-range to short-range synaptic transition in NHEJ

(2021) Siyu Chen et al.   NATURE

Cryo-EM of NHEJ supercomplexes provides insights into DNA repair

(2021) Amanda K. Chaplin et al.   MOLECULAR CELL

Staring at the Naked Goddess: Unraveling the Structure and Reactivity of Artemis Endonuclease Interacting with a DNA Double Strand

(2021) Cécilia Hognon et al.   MOLECULES

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Highly accurate protein structure prediction for the human proteome

(2021) Kathryn Tunyasuvunakool et al.   NATURE

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family

(2021) Hannah T Baddock et al.   NUCLEIC ACIDS RESEARCH

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition

(2021) Yuliana Yosaatmadja et al.   NUCLEIC ACIDS RESEARCH

Inner workings of RAG recombinase and its specialization for adaptive immunity

(2021) Xuemin Chen et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

(2021) Lan Liu et al.   MOLECULAR CELL

Cutting antiparallel DNA strands in a single active site

(2020) Xuemin Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural analysis of the catalytic domain of Artemis endonuclease/SNM1C reveals distinct structural features

(2020) Md Fazlul Karim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The molecular basis and disease relevance of non-homologous DNA end joining

(2020) Bailin Zhao et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dimers of DNA-PK create a stage for DNA double-strand break repair

(2020) Amanda K. Chaplin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stages, scaffolds and strings in the spatial organisation of non-homologous end joining: Insights from X-ray diffraction and Cryo-EM

(2020) Shikang Liang et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The essential elements for the noncovalent association of two DNA ends during NHEJ synapsis

(2019) Bailin Zhao et al.   Nature Communications

Cracking the DNA Code for V(D)J Recombination

(2018) Min-Sung Kim et al.   MOLECULAR CELL

Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity

(2017) Christina A. Gerodimos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autoinhibition of the Nuclease ARTEMIS Is Mediated by a Physical Interaction between Its Catalytic and C-terminal Domains

(2017) Doris Niewolik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nonhomologous DNA end-joining for repair of DNA double-strand breaks

(2017) Nicholas R. Pannunzio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Specific nuclease activities of Artemis and the Artemis: DNA-PKcs complex

(2016) Howard H.Y. Chang et al.   NUCLEIC ACIDS RESEARCH

The Chemical Biology of Human Metallo-β-Lactamase Fold Proteins

(2016) Ilaria Pettinati et al.   TRENDS IN BIOCHEMICAL SCIENCES

Functional analysis of naturally occurring DCLRE1C mutations and correlation with the clinical phenotype of ARTEMIS deficiency

(2015) Kerstin Felgentreff et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation

(2014) J. A. Neal et al.   MOLECULAR AND CELLULAR BIOLOGY

Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs

(2012) Shruti Malu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNA-PKcs regulates a single-stranded DNA endonuclease activity of Artemis

(2010) Jiafeng Gu et al.   DNA REPAIR

Nucleases: diversity of structure, function and mechanism

(2010) Wei Yang   QUARTERLY REVIEWS OF BIOPHYSICS

Impact of a hypomorphic Artemis disease allele on lymphocyte development, DNA end processing, and genome stability

(2009) Ying Huang et al.   JOURNAL OF EXPERIMENTAL MEDICINE