New insights into the evolutionary conservation of the sole PIKK pseudokinase Tra1/TRRAP

Prospects for pharmacological targeting of pseudokinases

(2019) Jennifer E. Kung et al.   NATURE REVIEWS DRUG DISCOVERY

The demise of catalysis, but new functions arise: pseudoenzymes as the phoenixes of the protein world

(2019) Constance J. Jeffery   BIOCHEMICAL SOCIETY TRANSACTIONS

Tracing the origin and evolution of pseudokinases across the tree of life

(2019) Annie Kwon et al.   Science Signaling

The EMBL-EBI search and sequence analysis tools APIs in 2019

(2019) Fábio Madeira et al.   NUCLEIC ACIDS RESEARCH

Chaperone-mediated ordered assembly of the SAGA and NuA4 transcription co-activator complexes in yeast

(2019) Alberto Elías-Villalobos et al.   Nature Communications

NGL viewer: web-based molecular graphics for large complexes

(2018) Alexander S Rose et al.   BIOINFORMATICS

Cryo-EM structure of human mTOR complex 2

(2018) Xizi Chen et al.   CELL RESEARCH

Branching the Tel2 pathway for exact fit on phosphatidylinositol 3-kinase-related kinases

(2018) Katsunori Sugimoto   CURRENT GENETICS

Architecture and activation of phosphatidylinositol 3-kinase related kinases

(2018) Stefan Imseng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Architecture of the Essential Yeast Histone Acetyltransferase Complex NuA4 Redefines Its Multimodularity

(2018) Dheva Setiaputra et al.   MOLECULAR AND CELLULAR BIOLOGY

The PAQosome, an R2TP-Based Chaperone for Quaternary Structure Formation

(2018) Walid A. Houry et al.   TRENDS IN BIOCHEMICAL SCIENCES

Architecture of the Saccharomyces cerevisiae NuA4/TIP60 complex

(2018) Xuejuan Wang et al.   Nature Communications

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

(2018) Lisa M. Tuttle et al.   Cell Reports

The Pseudokinase Domain of Saccharomyces cerevisiae Tra1 Is Required for Nuclear Localization and Incorporation into the SAGA and NuA4 Complexes

(2018) Matthew D. Berg et al.   G3-Genes Genomes Genetics

Protein AMPylation by an Evolutionarily Conserved Pseudokinase

(2018) Anju Sreelatha et al.   CELL

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1

(2018) Sam A. Jamieson et al.   Science Signaling

Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells

(2018) Daniel M. Foulkes et al.   Science Signaling

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

The HSP90 chaperone machinery

(2017) Florian H. Schopf et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3.9 Å structure of the yeast Mec1-Ddc2 complex, a homolog of human ATR-ATRIP

(2017) Xuejuan Wang et al.   SCIENCE

DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair

(2017) Bancinyane L. Sibanda et al.   SCIENCE

Sharing the SAGA

(2017) Dominique Helmlinger et al.   TRENDS IN BIOCHEMICAL SCIENCES

How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches

(2017) Kliment A. Verba et al.   TRENDS IN BIOCHEMICAL SCIENCES

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Structure of the transcription activator target Tra1 within the chromatin modifying complex SAGA

(2017) Grigory Sharov et al.   Nature Communications

Two separate pathways regulate protein stability of ATM/ATR-related protein kinases Mec1 and Tel1 in budding yeast

(2017) Greicy H. Goto et al.   PLoS Genetics

Cryo-EM structure of the SAGA and NuA4 coactivator subunit Tra1 at 3.7 angstrom resolution

(2017) Luis Miguel Díaz-Santín et al.   eLife

Structures of closed and open conformations of dimeric human ATM

(2017) Domagoj Baretić et al.   Science Advances

CK2 phospho-independent assembly of the Tel2-associated stress-signaling complexes inSchizosaccharomyces pombe

(2016) Haruna Inoue et al.   GENES TO CELLS

Saccharomyces cerevisiae Tti2 Regulates PIKK Proteins and Stress Response

(2016) Kyle S. Hoffman et al.   G3-Genes Genomes Genetics

Conformational Flexibility and Subunit Arrangement of the Modular Yeast Spt-Ada-Gcn5 Acetyltransferase Complex

(2015) Dheva Setiaputra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex

(2014) Y. Han et al.   EMBO JOURNAL

Structures of SMG1-UPFs Complexes: SMG1 Contributes to Regulate UPF2-Dependent Activation of UPF1 in NMD

(2014) Roberto Melero et al.   STRUCTURE

Day of the dead: pseudokinases and pseudophosphatases in physiology and disease

(2014) Veronika Reiterer et al.   TRENDS IN CELL BIOLOGY

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties

(2013) James M. Murphy et al.   BIOCHEMICAL JOURNAL

Dawn of the dead: protein pseudokinases signal new adventures in cell biology

(2013) Patrick A. Eyers et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic Evidence Links the ASTRA Protein Chaperone Component Tti2 to the SAGA Transcription Factor Tra1

(2012) Julie Genereaux et al.   GENETICS

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

(2012) Sang Gyun Kim et al.   MOLECULAR CELL

Analysis of Gal4-directed transcription activation using Tra1 mutants selectively defective for interaction with Gal4

(2012) L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heat shock protein 90 regulates phosphatidylinositol 3-kinase-related protein kinase family proteins together with the RUVBL1/2 and Tel2-containing co-factor complex

(2011) Natsuko Izumi et al.   CANCER SCIENCE

Tra1 has specific regulatory roles, rather than global functions, within the SAGA co-activator complex

(2011) Dominique Helmlinger et al.   EMBO JOURNAL

The minimal kinome of Giardia lamblia illuminates early kinase evolution and unique parasite biology

(2011) Gerard Manning et al.   GENOME BIOLOGY

Mutational analysis of the C-terminal FATC domain of Saccharomyces cerevisiae Tra1

(2010) Stephen M. T. Hoke et al.   CURRENT GENETICS

Multiple faces of the SAGA complex

(2010) Evangelia Koutelou et al.   CURRENT OPINION IN CELL BIOLOGY

Pseudokinases-remnants of evolution or key allosteric regulators?

(2010) Elton Zeqiraj et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes

(2010) H. Takai et al.   GENES & DEVELOPMENT

A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

(2010) K. E. Hurov et al.   GENES & DEVELOPMENT

Transformation/Transcription Domain-Associated Protein (TRRAP)-Mediated Regulation of Wee1

(2010) T. M. Calonge et al.   GENETICS

Tti1 and Tel2 Are Critical Factors in Mammalian Target of Rapamycin Complex Assembly

(2010) Takeshi Kaizuka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Mediator Recruitment by Tandem Gcn4 Activation Domains and Three Gal11 Activator-Binding Domains

(2010) E. Herbig et al.   MOLECULAR AND CELLULAR BIOLOGY

Domains of Tra1 Important for Activator Recruitment and Transcription Coactivator Functions of SAGA and NuA4 Complexes

(2010) B. A. Knutson et al.   MOLECULAR AND CELLULAR BIOLOGY

NuA4 and SWR1-C: two chromatin-modifying complexes with overlapping functions and componentsThis paper is one of a selection of papers published in this Special Issue, entitled 30th Annual International Asilomar Chromatin and Chromosomes Conference, and has undergone the Journal's usual peer review process.

(2009) Phoebe Y.T. Lu et al.   Biochemistry and Cell Biology

Emerging common themes in regulation of PIKKs and PI3Ks

(2009) Harri Lempiäinen et al.   EMBO JOURNAL

Tel2 mediates activation and localization of ATM/Tel1 kinase to a double-strand break

(2008) C. M. Anderson et al.   GENES & DEVELOPMENT

Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment

(2008) Anna Shevchenko et al.   GENOME BIOLOGY