From inflammation to renal fibrosis: A one-way road in autoimmunity?

Galectin-3 in Kidney Diseases: From an Old Protein to a New Therapeutic Target

(2022) Louis Boutin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Urinary Galectin-3 as a Novel Biomarker for the Prediction of Renal Fibrosis and Kidney Disease Progression

(2022) Shuo-Ming Ou et al.   Biomedicines

Renal histology across the stages of chronic kidney disease

(2021) F. Trevisani et al.   JOURNAL OF NEPHROLOGY

Role of intracellular complement activation in kidney fibrosis

(2021) Didier Portilla et al.   BRITISH JOURNAL OF PHARMACOLOGY

Organ Fibrosis and Autoimmunity: The Role of Inflammation in TGFβ-Dependent EMT

(2021) Margherita Sisto et al.   Biomolecules

Druggability of lipid metabolism modulation against renal fibrosis

(2021) Yuan-yuan Chen et al.   ACTA PHARMACOLOGICA SINICA

Value of [68Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis

(2021) Yue Zhou et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Key metalloproteinase-mediated pathways in the kidney

(2021) Justyna Wozniak et al.   Nature Reviews Nephrology

Transforming Growth Factor-β and Long Non-coding RNA in Renal Inflammation and Fibrosis

(2021) Yue-Yu Gu et al.   Frontiers in Physiology

Primary results of the randomized trial of metformin administration in polycystic kidney disease (TAME PKD)

(2021) Ronald D. Perrone et al.   KIDNEY INTERNATIONAL

Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence

(2021) Megan Vierhout et al.   WOUND REPAIR AND REGENERATION

Perspectives on the Role of Magnetic Resonance Imaging (MRI) for Noninvasive Evaluation of Diabetic Kidney Disease

(2021) José María Mora-Gutiérrez et al.   Journal of Clinical Medicine

Different Patterns of Kidney Fibrosis Are Indicative of Injury to Distinct Renal Compartments

(2021) Désirée Tampe et al.   Cells

Detection and quantification of renal fibrosis by computerized tomography

(2020) Eric P. Cohen et al.   PLoS One

Extra-cellular matrix induced by steroids and aging through a G-protein coupled receptor in a Drosophila model of renal fibrosis

(2020) Wenjing Zheng et al.   Disease Models & Mechanisms

Targeting the progression of chronic kidney disease

(2020) Marta Ruiz-Ortega et al.   Nature Reviews Nephrology

Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2–Dependent Mechanism in Polycystic Kidney Disease

(2020) Nidhi Dwivedi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Global transcriptomic changes occur in aged mouse podocytes.

(2020) Yuliang Wang et al.   KIDNEY INTERNATIONAL

Phosphoinositide 3-kinase γ deficiency attenuates kidney injury and fibrosis in angiotensin II–induced hypertension

(2020) Changlong An et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Neural transcription factor Pou4f1 promotes renal fibrosis via macrophage–myofibroblast transition

(2020) Patrick Ming-Kuen Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mycophenolate Mofetil in C3 Glomerulopathy and Pathogenic Drivers of the Disease

(2020) Fernando Caravaca-Fontán et al.   Clinical Journal of the American Society of Nephrology

WNT–β-catenin signalling — a versatile player in kidney injury and repair

(2020) Stefan J. Schunk et al.   Nature Reviews Nephrology

TGFβ-Directed Therapeutics: 2020

(2020) Beverly A. Teicher   PHARMACOLOGY & THERAPEUTICS

Synergistic Inhibition of Renal Fibrosis by Nintedanib and Gefitinib in a Murine Model of Obstructive Nephropathy

(2020) Liu Feng et al.   Kidney Diseases

Diffusion Tensor Imaging in early prediction of renal fibrosis in patients with renal disease: Functional and histopathological correlations

(2020) Mohammed K. Nassar et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Repurposing of metformin and colchicine reveals differential modulation of acute and chronic kidney injury

(2020) Maryam El-Rashid et al.   Scientific Reports

Use of nintedanib in interstitial lung disease other than idiopathic pulmonary fibrosis: much caution is warranted

(2020) Marco Mura   PULMONARY PHARMACOLOGY & THERAPEUTICS

Molecular imaging of fibrosis: recent advances and future directions

(2019) Sydney B. Montesi et al.   JOURNAL OF CLINICAL INVESTIGATION

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Targeting senescent cells alleviates obesity‐induced metabolic dysfunction

(2019) Allyson K. Palmer et al.   AGING CELL

Dkk (Dickkopf) Proteins

(2019) Roberta Baetta et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF‐α‐Smurf1‐Akt‐mTOR‐P70S6K pathway

(2019) Jiajun Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

(2019) Meiling Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pentoxifylline, progression of chronic kidney disease (CKD) and cardiovascular mortality: long-term follow-up of a randomized clinical trial

(2019) Alejandra Muñoz de Morales et al.   JOURNAL OF NEPHROLOGY

Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial

(2019) Hiddo J L Heerspink et al.   LANCET

Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy

(2019) Vlado Perkovic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nintedanib for Systemic Sclerosis–Associated Interstitial Lung Disease

(2019) Oliver Distler et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pentoxifylline for Renal Protection in Diabetic Kidney Disease. A Model of Old Drugs for New Horizons

(2019) Javier Donate-Correa et al.   Journal of Clinical Medicine

Application of nintedanib and other potential anti-fibrotic agents in fibrotic diseases

(2019) Feng Liu et al.   CLINICAL SCIENCE

Biomarkers of Chronic Renal Tubulointerstitial Injury

(2019) Serena M. Bagnasco et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Glomerular Volume and Glomerulosclerosis at Different Depths within the Human Kidney

(2019) Aleksandar Denic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

(2019) Bryna S. M. Chow et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo

(2019) Maike Baues et al.   KIDNEY INTERNATIONAL

Nintedanib in Progressive Fibrosing Interstitial Lung Diseases

(2019) Kevin R. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin-II Drives Human Satellite Cells Toward Hypertrophy and Myofibroblast Trans-Differentiation by Two Independent Pathways

(2019) Annunziatina Laurino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pathogenesis of Fabry nephropathy: The pathways leading to fibrosis

(2019) Paula Adriana Rozenfeld et al.   MOLECULAR GENETICS AND METABOLISM

Renal thrombotic microangiopathy during nintedanib treatment for idiopathic pulmonary fibrosis

(2019) Daisuke Inoue et al.   CLINICAL NEPHROLOGY

Metformin attenuates folic-acid induced renal fibrosis in mice

(2018) Hao Yi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Prognostic Value of Histopathologic Lesions in Native Kidney Biopsy Specimens: Results from the Boston Kidney Biopsy Cohort Study

(2018) Anand Srivastava et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

C3 glomerulonephritis and dense deposit disease share a similar disease course in a large United States cohort of patients with C3 glomerulopathy

(2018) Andrew S. Bomback et al.   KIDNEY INTERNATIONAL

Revision of the International Society of Nephrology/Renal Pathology Society classification for lupus nephritis: clarification of definitions, and modified National Institutes of Health activity and chronicity indices

(2018) Ingeborg M. Bajema et al.   KIDNEY INTERNATIONAL

The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring

(2018) Patrick Ming-Kuen Tang et al.   KIDNEY INTERNATIONAL

Safety of outpatient percutaneous native renal biopsy in systemic autoimmune diseases: results from a monocentric cohort

(2018) D Roccatello et al.   LUPUS

Pericytes in the renal vasculature: roles in health and disease

(2018) Isaac Shaw et al.   Nature Reviews Nephrology

OUP accepted manuscript

(2018)   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeting TGF-β Signaling in Kidney Fibrosis

(2018) Yoshitaka Isaka   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Advances in understanding the role of angiotensin-regulated proteins in kidney diseases

(2018) Ana Belén Sanz et al.   Expert Review of Proteomics

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

(2018) Sandra Rayego-Mateos et al.   MEDIATORS OF INFLAMMATION

New insights into the role and mechanism of Wnt/β-catenin signalling in kidney fibrosis

(2018) Yangyang Zuo et al.   NEPHROLOGY

Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney DiseaseNovelty and Significance

(2017) Lionel Lattenist et al.   HYPERTENSION

Redirecting TGF-βSignaling through theβ-Catenin/Foxo Complex Prevents Kidney Fibrosis

(2017) Xi Qiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

(2017) Ying-Ying Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary collagen degradation products as early markers of progressive renal fibrosis

(2017) Ryanne S. Hijmans et al.   Journal of Translational Medicine

A proposal for standardized grading of chronic changes in native kidney biopsy specimens

(2017) Sanjeev Sethi et al.   KIDNEY INTERNATIONAL

Evidence from the Oxford Classification cohort supports the clinical value of subclassification of focal segmental glomerulosclerosis in IgA nephropathy

(2017) Shubha S. Bellur et al.   KIDNEY INTERNATIONAL

Colchicine attenuates renal fibrosis in a murine unilateral ureteral obstruction model

(2017) Seiji Itano et al.   Molecular Medicine Reports

Single-Nephron Glomerular Filtration Rate in Healthy Adults

(2017) Aleksandar Denic et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nutritional Management of Chronic Kidney Disease

(2017) Kamyar Kalantar-Zadeh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

(2017) Min Liu et al.   Nature Communications

Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?

(2017) Pedro Magalhães et al.   Scientific Reports

Outpatient percutaneous native renal biopsy: safety profile in a large monocentric cohort

(2017) Dario Roccatello et al.   BMJ Open

The JNK Signaling Pathway in Renal Fibrosis

(2017) Keren Grynberg et al.   Frontiers in Physiology

Chronic kidney disease

(2017) Paola Romagnani et al.   Nature Reviews Disease Primers

Colchicine in Renal Medicine: New Virtues of an Ancient Friend

(2016) Yalcin Solak et al.   BLOOD PURIFICATION

The Substantial Loss of Nephrons in Healthy Human Kidneys with Aging

(2016) Aleksandar Denic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of PDGF-D in healthy and fibrotic kidneys

(2016) Eva M. Buhl et al.   KIDNEY INTERNATIONAL

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

The epidermal growth factor receptor pathway in chronic kidney diseases

(2016) Laura R. Harskamp et al.   Nature Reviews Nephrology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

The effects of AST-120 on chronic kidney disease progression in the United States of America: a post hoc subgroup analysis of randomized controlled trials

(2016) Gerald Schulman et al.   BMC Nephrology

Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis

(2016) Xiao-Ming Meng et al.   Cell Death & Disease

Quercetin Inhibits Fibroblast Activation and Kidney Fibrosis Involving the Suppression of Mammalian Target of Rapamycin and β-catenin Signaling

(2016) Jiafa Ren et al.   Scientific Reports

Atrasentan increased the expression of klotho by mediating miR-199b-5p and prevented renal tubular injury in diabetic nephropathy

(2016) Wen-Ling Kang et al.   Scientific Reports

Nephrin Preserves Podocyte Viability and Glomerular Structure and Function in Adult Kidneys

(2015) X. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diverse origins of the myofibroblast—implications for kidney fibrosis

(2015) Lucas L. Falke et al.   Nature Reviews Nephrology

TGF-β/Smad3 signalling regulates the transition of bone marrowderived macrophages into myofibroblasts during tissue fibrosis

(2015) Shuang Wang et al.   Oncotarget

Role of bone morphogenetic protein-7 in renal fibrosis

(2015) Rui Xi Li et al.   Frontiers in Physiology

Randomized Placebo-Controlled EPPIC Trials of AST-120 in CKD

(2014) G. Schulman et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autophagy Regulates TGF-  Expression and Suppresses Kidney Fibrosis Induced by Unilateral Ureteral Obstruction

(2014) Y. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inflammatory processes in renal fibrosis

(2014) Xiao-Ming Meng et al.   Nature Reviews Nephrology

Targeting CTGF, EGF and PDGF pathways to prevent progression of kidney disease

(2014) Helena M. Kok et al.   Nature Reviews Nephrology

A Critical Role for the mTORC2 Pathway in Lung Fibrosis

(2014) Wenteh Chang et al.   PLoS One

Design of the INPULSIS™ trials: Two phase 3 trials of nintedanib in patients with idiopathic pulmonary fibrosis

(2014) Luca Richeldi et al.   RESPIRATORY MEDICINE

Macrophages promote renal fibrosis through direct and indirect mechanisms

(2014) David J. Nikolic-Paterson et al.   Kidney International Supplements

What is the best way to measure renal fibrosis?: A pathologist’s perspective

(2014) Alton B. Farris et al.   Kidney International Supplements

The FOXD1 lineage of kidney perivascular cells and myofibroblasts: functions and responses to injury

(2014) Ivan G. Gomez et al.   Kidney International Supplements

Wnt/β-catenin signaling and kidney fibrosis

(2014) Roderick J. Tan et al.   Kidney International Supplements

First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics

(2013) Hazel H Szeto   BRITISH JOURNAL OF PHARMACOLOGY

Fibrocytes develop outside the kidney but contribute to renal fibrosis in a mouse model

(2013) Barbara Reich et al.   KIDNEY INTERNATIONAL

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Role of the TGF-β/BMP-7/Smad pathways in renal diseases

(2012) Xiao-Ming Meng et al.   CLINICAL SCIENCE

Non-invasive assessment of renal allograft fibrosis by dynamic sonographic tissue perfusion measurement

(2011) Trygve Syversveen et al.   ACTA RADIOLOGICA

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

A Nexus of Progression of Chronic Kidney Disease: Tryptophan, Profibrotic Cytokines, and Charcoal

(2011) Gerald Schulman   JOURNAL OF RENAL NUTRITION

Tubular Lesions Predict Renal Outcome in Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis after Rituximab Therapy

(2011) A. E. Berden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CXCL16 Recruits Bone Marrow-Derived Fibroblast Precursors in Renal Fibrosis

(2011) G. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro

(2011) Xiao-Ming Meng et al.   KIDNEY INTERNATIONAL

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy

(2010) J. Li et al.   DIABETES

Essential role for Smad3 in angiotensin II-induced tubular epithelial-mesenchymal transition

(2010) Fuye Yang et al.   JOURNAL OF PATHOLOGY

Morphometric and Visual Evaluation of Fibrosis in Renal Biopsies

(2010) A. B. Farris et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Smad2 Protects against TGF- /Smad3-Mediated Renal Fibrosis

(2010) X. M. Meng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pivotal role of CD4+ T cells in renal fibrosis following ureteric obstruction

(2010) Thomas T. Tapmeier et al.   KIDNEY INTERNATIONAL

Endothelial-Myofibroblast Transition Contributes to the Early Development of Diabetic Renal Interstitial Fibrosis in Streptozotocin-Induced Diabetic Mice

(2009) Jinhua Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Kank proteins: structure, functions and diseases

(2009) N. Kakinuma et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury

(2009) Felix Heymann et al.   JOURNAL OF CLINICAL INVESTIGATION

Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury

(2009) Maria Teresa Gandolfo et al.   KIDNEY INTERNATIONAL

The renal cortical interstitium: morphological and functional aspects

(2008) Brigitte Kaissling et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Fibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition

(2008) E. M. Zeisberg et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY