Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2–Dependent Mechanism in Polycystic Kidney Disease

A RhoA–YAP–c-Myc signaling axis promotes the development of polycystic kidney disease

(2018) Jing Cai et al.   GENES & DEVELOPMENT

Connective tissue growth factor (CTGF) from basics to clinics

(2018) Yasaman Ramazani et al.   MATRIX BIOLOGY

A Practical Guide for Treatment of Rapidly Progressive ADPKD with Tolvaptan

(2018) Fouad T. Chebib et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

YAP/TAZ Signaling as a Molecular Link between Fibrosis and Cancer

(2018) Satoshi Noguchi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased YAP Activation Is Associated With Hepatic Cyst Epithelial Cell Proliferation in ARPKD/CHF

(2017) Lu Jiang et al.   GENE EXPRESSION

Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor–Related Protein 6

(2017) Bryce G. Johnson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis

(2017) Hiroshi Kinashi et al.   KIDNEY INTERNATIONAL

Cancer associated fibroblasts: An essential role in the tumor microenvironment

(2017) Leilei Tao et al.   Oncology Letters

A cAMP and CREB-mediated feed-forward mechanism regulates GSK3βin polycystic kidney disease

(2016) Vijayakumar R. Kakade et al.   Journal of Molecular Cell Biology

Glycogen synthase kinase-3β promotes cyst expansion in polycystic kidney disease

(2015) Shixin Tao et al.   KIDNEY INTERNATIONAL

Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

(2015) Arlene B. Chapman et al.   KIDNEY INTERNATIONAL

The clinically used photosensitizer Verteporfin (VP) inhibits YAP-TEAD and human retinoblastoma cell growth in vitro without light activation

(2014) Katarzyna Brodowska et al.   EXPERIMENTAL EYE RESEARCH

Tolvaptan plus Pasireotide Shows Enhanced Efficacy in a PKD1 Model

(2014) K. Hopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Hippo Signaling by EGFR-MAPK Signaling through Ajuba Family Proteins

(2013) B.V.V.G. Reddy et al.   DEVELOPMENTAL CELL

cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes

(2013) Minchul Kim et al.   EMBO JOURNAL

MEK1 promotes YAP and their interaction is critical for tumorigenesis in liver cancer

(2013) Lanlan Li et al.   FEBS LETTERS

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Understanding the origin, activation and regulation of matrix-producing myofibroblasts for treatment of fibrotic disease

(2013) Rafael Kramann et al.   JOURNAL OF PATHOLOGY

Strategies Targeting cAMP Signaling in the Treatment of Polycystic Kidney Disease

(2013) V. E. Torres et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

(2013) Randy Johnson et al.   NATURE REVIEWS DRUG DISCOVERY

Oxytocin and Vasopressin Agonists and Antagonists as Research Tools and Potential Therapeutics

(2012) M. Manning et al.   JOURNAL OF NEUROENDOCRINOLOGY

Fibrosis and progression of Autosomal Dominant Polycystic Kidney Disease (ADPKD)

(2011) Jill Norman   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Altered Hippo signalling in polycystic kidney disease

(2011) Hester Happé et al.   JOURNAL OF PATHOLOGY

CCN2 is required for bleomycin-induced skin fibrosis in mice

(2010) Shangxi Liu et al.   ARTHRITIS AND RHEUMATISM

Cyclic AMP-mediated cyst expansion

(2010) Darren P. Wallace   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Elevated TGFβ-Smad signalling in experimental Pkd1 models and human patients with polycystic kidney disease

(2010) Sabrine Hassane et al.   JOURNAL OF PATHOLOGY

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networks

(2009) Xuewen Song et al.   HUMAN MOLECULAR GENETICS

CTGF Inhibits BMP-7 Signaling in Diabetic Nephropathy

(2008) T. Q. Nguyen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Physiology and pathophysiology of the vasopressin-regulated renal water reabsorption

(2008) Michelle Boone et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Vasopressin Directly Regulates Cyst Growth in Polycystic Kidney Disease

(2007) X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Overexpression of innate immune response genes in a model of recessive polycystic kidney disease

(2007) M. Mrug et al.   KIDNEY INTERNATIONAL