Role of intracellular complement activation in kidney fibrosis

The long-acting C5 inhibitor, Ravulizumab, is effective and safe in adult patients with atypical hemolytic uremic syndrome naïve to complement inhibitor treatment.

(2020) Eric Rondeau et al.   KIDNEY INTERNATIONAL

Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab

(2020) Lionel Rougé et al.   SCIENCE

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

(2020) Samuel M.-W. Yu et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

A Randomized Trial of Recombinant Human C1-Esterase-Inhibitor in the Prevention of Contrast-Induced Kidney Injury

(2020) Anneza Panagiotou et al.   JACC-Cardiovascular Interventions

Complement Deficiencies Result in Surrogate Pathways of Complement Activation in Novel Polygenic Lupus-like Models of Kidney Injury

(2020) Sladjana Skopelja-Gardner et al.   JOURNAL OF IMMUNOLOGY

Complement activation profile of patients with primary focal segmental glomerulosclerosis

(2020) Jing Huang et al.   PLoS One

Binding mechanisms of therapeutic antibodies to human CD20

(2020) Anand Kumar et al.   SCIENCE

Podocytes Produce and Secrete Functional Complement C3 and Complement Factor H

(2020) Anne K. Mühlig et al.   Frontiers in Immunology

Complement-mediated kidney diseases

(2020) Felix Poppelaars et al.   MOLECULAR IMMUNOLOGY

Recent advances in acute kidney injury and its consequences and impact on chronic kidney disease

(2019) Anna Zuk et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Specific inhibition of the classical complement pathway prevents C3 deposition along the dermal-epidermal junction in bullous pemphigoid

(2019) Patricia Colchete Freire et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Complement Inhibitors in Clinical Trials for Glomerular Diseases

(2019) Peter F. Zipfel et al.   Frontiers in Immunology

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Tissue-targeted complement therapeutics

(2018) Stephen Tomlinson et al.   MOLECULAR IMMUNOLOGY

A prospective randomized, controlled trial of eculizumab to prevent ischemia-reperfusion injury in pediatric kidney transplantation

(2018) Michael Kaabak et al.   PEDIATRIC TRANSPLANTATION

Back to the future – non-canonical functions of complement

(2018) Claudia Kemper et al.   SEMINARS IN IMMUNOLOGY

A Novel Role for C5a in B-1 Cell Homeostasis

(2018) Katharina Bröker et al.   Frontiers in Immunology

Complement Activation During Ischemia/Reperfusion Injury Induces Pericyte-to-Myofibroblast Transdifferentiation Regulating Peritubular Capillary Lumen Reduction Through pERK Signaling

(2018) Giuseppe Castellano et al.   Frontiers in Immunology

A Systematic Review and Meta-analysis of Prevalence of Biopsy-Proven Lupus Nephritis

(2018) Hong Wang   Archives of Rheumatology

Advantages of Single-Nucleus over Single-Cell RNA Sequencing of Adult Kidney: Rare Cell Types and Novel Cell States Revealed in Fibrosis

(2018) Haojia Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Collectin-11 Promotes the Development of Renal Tubulointerstitial Fibrosis

(2017) Weiju Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis

(2017) David R.W. Jayne et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Atypical hemolytic uremic syndrome and C3 glomerulopathy: conclusions from a “Kidney Disease: Improving Global Outcomes” (KDIGO) Controversies Conference

(2017) Timothy H.J. Goodship et al.   KIDNEY INTERNATIONAL

C1q: A fresh look upon an old molecule

(2017) Nicole M. Thielens et al.   MOLECULAR IMMUNOLOGY

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions

(2017) Jinhua Lu et al.   Frontiers in Immunology

Periodontal Ehlers-Danlos Syndrome Is Caused by Mutations in C1R and C1S , which Encode Subcomponents C1r and C1s of Complement

(2016) Ines Kapferer-Seebacher et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Simultaneous pancreas–kidney transplantation in patients with type 1 diabetes reverses elevated MBL levels in association with MBL2 genotype and VEGF expression

(2016) Roel Bijkerk et al.   DIABETOLOGIA

A journey through the lectin pathway of complement-MBL and beyond

(2016) Peter Garred et al.   IMMUNOLOGICAL REVIEWS

Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury

(2016) Conrad A. Farrar et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct roles for the complement regulators factor H and Crry in protection of the kidney from injury

(2016) Jennifer Laskowski et al.   KIDNEY INTERNATIONAL

Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway

(2016) Ana Catarina Lunz Macedo et al.   Frontiers in Immunology

Thrombotic Microangiopathy in Systemic Lupus Erythematosus: Efficacy of Eculizumab

(2015) Amr El-Husseini et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Complement in Kidney Disease: Core Curriculum 2015

(2015) Joshua M. Thurman   AMERICAN JOURNAL OF KIDNEY DISEASES

Plasma levels of mannan-binding lectin-associated serine proteases MASP-1 and MASP-2 are elevated in type 1 diabetes and correlate with glycaemic control

(2015) L. Jenny et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

RNA Sequencing Identifies Novel Translational Biomarkers of Kidney Fibrosis

(2015) F. L. Craciun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deep Sequencing in Microdissected Renal Tubules Identifies Nephron Segment-Specific Transcriptomes

(2015) J. W. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diabetic kidney disease: a clinical update from Kidney Disease: Improving Global Outcomes

(2015) Mark E. Molitch et al.   KIDNEY INTERNATIONAL

Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

(2015) Chandra Mohan et al.   Nature Reviews Nephrology

Epigenetic regulation in the acute kidney injury to chronic kidney disease transition

(2015) Roxana Rodríguez-Romo et al.   NEPHROLOGY

Emerging and Novel Functions of Complement Protein C1q

(2015) Lubna Kouser et al.   Frontiers in Immunology

Peptide Inhibitor of Complement C1 (PIC1) Rapidly Inhibits Complement Activation after Intravascular Injection in Rats

(2015) Julia A. Sharp et al.   PLoS One

Association of the pattern recognition molecule H-ficolin with incident microalbuminuria in an inception cohort of newly diagnosed type 1 diabetic patients: an 18 year follow-up study

(2014) Jakob A. Østergaard et al.   DIABETOLOGIA

Trends in the epidemiology and care of diabetes mellitus-related end-stage renal disease in France, 2007–2011

(2014) Frank G. A. Assogba et al.   DIABETOLOGIA

Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4

(2014) Elham Asgari et al.   FASEB JOURNAL

C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

(2014) H. Paidassi et al.   JOURNAL OF IMMUNOLOGY

Specific Macrophage Subtypes Influence the Progression of Rhabdomyolysis-Induced Kidney Injury

(2014) J. Belliere et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Immune cells in experimental acute kidney injury

(2014) Hye Ryoun Jang et al.   Nature Reviews Nephrology

Eculizumab treatment for rescue of renal function in IgA nephropathy

(2014) Therese Rosenblad et al.   PEDIATRIC NEPHROLOGY

Deciphering the Fine Details of C1 Assembly and Activation Mechanisms: “Mission Impossible”?

(2014) Christine Gaboriaud et al.   Frontiers in Immunology

Renal epithelial injury and fibrosis

(2013) Brigitte Kaissling et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation

(2013) Jing Zhang et al.   FASEB JOURNAL

Intracellular Complement Activation Sustains T Cell Homeostasis and Mediates Effector Differentiation

(2013) M. Kathryn Liszewski et al.   IMMUNITY

Macrophage Phenotype Controls Long-Term AKI Outcomes--Kidney Regeneration versus Atrophy

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Reduction of DNA hydroxymethylation in the mouse kidney insulted by ischemia reperfusion

(2012) Ning Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The tick-over theory revisited: Is C3 a contact-activated protein?

(2012) Bo Nilsson et al.   IMMUNOBIOLOGY

C1q and phagocytosis: the perfect complement to a good meal

(2012) M. D. Galvan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

C3a and C5a Promote Renal Ischemia-Reperfusion Injury

(2012) Q. Peng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Diagnostic value of serum anti-C1q antibodies in patients with lupus nephritis: a meta-analysis

(2012) Y Yin et al.   LUPUS

Terminal Complement Inhibition Decreases Antibody-Mediated Rejection in Sensitized Renal Transplant Recipients

(2011) M. D. Stegall et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Distinct roles for C3a and C5a in complement-induced tubulointerstitial injury

(2011) Lihua Bao et al.   KIDNEY INTERNATIONAL

Pathophysiology of ischemic acute kidney injury

(2011) Asif A. Sharfuddin et al.   Nature Reviews Nephrology

Mechanisms of tissue injury in lupus nephritis

(2011) Tamara K Nowling et al.   ARTHRITIS RESEARCH & THERAPY

Management of Paroxysmal Nocturnal Hemoglobinuria in the Era of Complement Inhibitory Therapy

(2011) C. J. Parker   Hematology-American Society of Hematology Education Program

Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes

(2010) Juliette Fortpied et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

C1 inhibitor, a multi-functional serine protease inhibitor

(2010) Fengxin Lu et al.   THROMBOSIS AND HAEMOSTASIS

C3a Mediates Epithelial-to-Mesenchymal Transition in Proteinuric Nephropathy

(2009) Z. Tang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement in human diseases: Lessons from complement deficiencies

(2009) Marina Botto et al.   MOLECULAR IMMUNOLOGY