Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage

Connective tissue growth factor induces renal fibrosis via epidermal growth factor receptor activation

(2018) Sandra Rayego-Mateos et al.   JOURNAL OF PATHOLOGY

Positive crosstalk between EGFR and the TF-PAR2 pathway mediates resistance to cisplatin and poor survival in cervical cancer

(2018) Vitor Hugo de Almeida et al.   Oncotarget

Curcumin inhibits epigen and amphiregulin upregulated by 2,4,6-trinitrochlorobenzene associated with attenuation of skin swelling

(2017) Hiroyasu Sakai et al.   INFLAMMATION RESEARCH

Neuregulin-1β induces proliferation, survival and paracrine signaling in normal human cardiac ventricular fibroblasts

(2017) Annet Kirabo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Connective tissue growth factor regulates fibrosis-associated renal lymphangiogenesis

(2017) Hiroshi Kinashi et al.   KIDNEY INTERNATIONAL

Deletion of connective tissue growth factor ameliorates peritoneal fibrosis by inhibiting angiogenesis and inflammation

(2017) Naohiro Toda et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epidermal growth factor-induced hydrogen peroxide production is mediated by dual oxidase 1

(2016) Gábor Sirokmány et al.   FREE RADICAL BIOLOGY AND MEDICINE

Considerations on inhibition approaches for proinflammatory functions of ADAM proteases

(2016) Daniela Dreymueller et al.   PLATELETS

Structural basis of selectivity and neutralizing activity of a TGFα/epiregulin specific antibody

(2016) Jeffrey S. Boyles et al.   PROTEIN SCIENCE

EGFR mediates hyperlipidemia-induced renal injury via regulating inflammation and oxidative stress: the detrimental role and mechanism of EGFR activation

(2016) Qilu Fang et al.   Oncotarget

Redox-dependent regulation of epidermal growth factor receptor signaling

(2016) David E. Heppner et al.   Redox Biology

The C-Terminal Module IV of Connective Tissue Growth Factor, Through EGFR/Nox1 Signaling, Activates the NF-κB Pathway and Proinflammatory Factors in Vascular Smooth Muscle Cells

(2015) Raúl R. Rodrigues-Diez et al.   ANTIOXIDANTS & REDOX SIGNALING

Amphiregulin may be a new biomarker of classically activated macrophages

(2015) Chen Meng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline

(2015) Alexander Stratigos et al.   EUROPEAN JOURNAL OF CANCER

High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells

(2015) Renzhong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Expression of Growth Factors Triggered by Epiregulin Regulates Inflammation Development

(2015) Masaya Harada et al.   JOURNAL OF IMMUNOLOGY

Basophil-Derived Amphiregulin Is Essential for UVB Irradiation–Induced Immune Suppression

(2015) Chantal Meulenbroeks et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Interaction of the EGF Receptor and the Hippo Pathway in the Diabetic Kidney

(2015) J. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The challenge of blocking a wider family members of EGFR against head and neck squamous cell carcinomas

(2015) Javier Martinez-Useros et al.   ORAL ONCOLOGY

Cetuximab and panitumumab in a patient with colon cancer and concomitant chronic skin disease: A potential beneficial effect on psoriasis vulgaris

(2015) Ken Okamoto   WORLD JOURNAL OF GASTROENTEROLOGY

Paricalcitol Inhibits Aldosterone-Induced Proinflammatory Factors by Modulating Epidermal Growth Factor Receptor Pathway in Cultured Tubular Epithelial Cells

(2015) Jose L. Morgado-Pascual et al.   Biomed Research International

Humble kidneys predict mighty heart troubles

(2015) Alberto Ortiz et al.   Lancet Diabetes & Endocrinology

Stress-Induced Neuroprotective Effects of Epiregulin and Amphiregulin

(2015) Libin Zhan et al.   PLoS One

Epidermal growth factor-induced proliferation of collecting duct cells from Oak Ridge polycystic kidney mice involves activation of Na+/H+ exchanger

(2014) Sonya D. Coaxum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice

(2014) M. Schafer et al.   EMBO Molecular Medicine

CRIPTO1 expression in EGFR-mutant NSCLC elicits intrinsic EGFR-inhibitor resistance

(2014) Kang-Seo Park et al.   JOURNAL OF CLINICAL INVESTIGATION

Overexpression of Epigen during Embryonic Development Induces Reversible, Epidermal Growth Factor Receptor-Dependent Sebaceous Gland Hyperplasia

(2014) Maik Dahlhoff et al.   MOLECULAR AND CELLULAR BIOLOGY

Epidermal Growth Factor Receptor Inhibition with Erlotinib Partially Prevents Cisplatin-Induced Nephrotoxicity in Rats

(2014) Yukihiro Wada et al.   PLoS One

Amphiregulin

(2014) Carmen Berasain et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

EGFR signaling in renal fibrosis

(2014) Shougang Zhuang et al.   Kidney International Supplements

The role of epidermal growth factor in prevention of oxidative injury and apoptosis induced by intestinal ischemia/reperfusion in rats

(2013) Pelin Arda-Pirincci et al.   ACTA HISTOCHEMICA

Increased activation of the epidermal growth factor receptor in transgenic mice overexpressing epigen causes peripheral neuropathy

(2013) Maik Dahlhoff et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Regulation of pancreatic inflammation by connective tissue growth factor (CTGF/CCN2)

(2013) Alyssa Charrier et al.   IMMUNOLOGY

EGF-like Growth Factors Induce COX-2–Derived PGE2 Production Through ERK1/2 in Human Granulosa Cells

(2013) Lanlan Fang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TWEAK transactivation of the epidermal growth factor receptor mediates renal inflammation

(2013) Sandra Rayego-Mateos et al.   JOURNAL OF PATHOLOGY

Low nitric oxide bioavailability upregulates renal heparin binding EGF-like growth factor expression

(2013) Tomoki Miyazawa et al.   KIDNEY INTERNATIONAL

The C-terminal module IV of connective tissue growth factor is a novel immune modulator of the Th17 response

(2013) Raquel Rodrigues-Díez et al.   LABORATORY INVESTIGATION

Molecular Determinants of Epidermal Growth Factor Binding: A Molecular Dynamics Study

(2013) Jeffrey M. Sanders et al.   PLoS One

Transformation of polarized epithelial cells by apical mistrafficking of epiregulin

(2013) B. Singh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Connective tissue growth factor is a new ligand of epidermal growth factor receptor

(2013) Sandra Rayego-Mateos et al.   Journal of Molecular Cell Biology

Disease-Association Analysis of an Inflammation-Related Feedback Loop

(2013) Masaaki Murakami et al.   Cell Reports

Clinical significance of amphiregulin and epidermal growth factor in colostrum

(2012) Takeshi Nojiri et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Increased Epidermal Growth Factor–Like Ligands Are Associated With Elevated Vascular Nicotinamide Adenine Dinucleotide Phosphate Oxidase in a Primate Model of Atherosclerosis

(2012) Bojana Stanic et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatocyte Growth Factor Inhibits Lipopolysaccharide-Induced Oxidative Stress via Epithelial Growth Factor Receptor Degradation

(2012) Kazutaka Shimizu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Induction of oxidative stress by oxidized LDL via meprinα-activated epidermal growth factor receptor in macrophages

(2012) Pan Gao et al.   CARDIOVASCULAR RESEARCH

TWEAK promotes the production of Interleukin-17 in rheumatoid arthritis

(2012) Jin-Sil Park et al.   CYTOKINE

Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation

(2012) Gianluca Aguiari et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Epidermal growth factor chronically upregulates Ca2+-dependent Cl−conductance and TMEM16A expression in intestinal epithelial cells

(2012) Magdalena S. Mroz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Deletion of the epidermal growth factor receptor in renal proximal tubule epithelial cells delays recovery from acute kidney injury

(2012) Jianchun Chen et al.   KIDNEY INTERNATIONAL

Acute kidney injury

(2012) Rinaldo Bellomo et al.   LANCET

Epidermal growth factor: a new therapeutic target in glomerular disease

(2012) M. Flamant et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium

(2012) Jamshid Pourazar et al.   Particle and Fibre Toxicology

Lower Urinary Connective Tissue Growth Factor Levels and Incident CKD Stage 3 in the General Population

(2011) Conall M. O'Seaghdha et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

TNF transactivation of EGFR stimulates cytoprotective COX-2 expression in gastrointestinal epithelial cells

(2011) Stuart S. Hobbs et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effects of Antiproteinuric Intervention on Elevated Connective Tissue Growth Factor (CTGF/CCN-2) Plasma and Urine Levels in Nondiabetic Nephropathy

(2011) M. C. J. Slagman et al.   Clinical Journal of the American Society of Nephrology

Epidermal Growth Factor Receptor Mediates the Vascular Dysfunction But Not the Remodeling Induced by Aldosterone/Salt

(2011) Violaine Griol-Charhbili et al.   HYPERTENSION

Mechanisms of Resistance to EGFR TKIs and Development of a New Generation of Drugs in Non-Small-Cell Lung Cancer

(2011) Takayuki Kosaka et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus

(2011) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Epidermal growth factor receptor promotes glomerular injury and renal failure in rapidly progressive crescentic glomerulonephritis

(2011) Guillaume Bollée et al.   NATURE MEDICINE

Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury

(2010) M. Shakil Ahmed et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells

(2010) Masahide Ebi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Epidermal growth factor-mediated proliferation and sodium transport in normal and PKD epithelial cells

(2010) Nadezhda N. Zheleznova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The CCN family: A new class of inflammation modulators?

(2010) L. Kular et al.   BIOCHIMIE

Effects of combined erythropoietin and epidermal growth factor on renal ischaemia/reperfusion injury: a randomized experimental controlled study

(2010) Abd El-Aziz M. Hussein et al.   BJU INTERNATIONAL

Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors

(2010) Deidi Strickland Bergestuen et al.   BMC CANCER

α1-Adrenoceptor-mediated contraction of rat aorta is partly mediated via transactivation of the epidermal growth factor receptor

(2010) N Ulu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crosstalks between the receptors tyrosine kinase EGFR and TrkA and the GPCR, FPR, in human monocytes are essential for receptors-mediated cell activation

(2010) Nabil El Zein et al.   CELLULAR SIGNALLING

Human basophils express amphiregulin in response to T cell–derived IL-3

(2010) Yilin Qi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Milk Epidermal Growth Factor and Gut Protection

(2010) Bohuslav Dvorak   JOURNAL OF PEDIATRICS

Bradykinin Decreases Podocyte Permeability through ADAM17-Dependent Epidermal Growth Factor Receptor Activation and Zonula Occludens-1 Rearrangement

(2010) M. Dey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Epidermal growth factor protects the heart against low-flow ischemia-induced injury

(2010) J. Lorita et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

TGF-  Mediates Genetic Susceptibility to Chronic Kidney Disease

(2010) D. Laouari et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

EGF receptor activation by GPCRs: An universal pathway reveals different versions

(2010) Claus Liebmann   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autosomal Recessive Polycystic Kidney Disease Epithelial Cell Model Reveals Multiple Basolateral Epidermal Growth Factor Receptor Sorting Pathways

(2010) Sean Ryan et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of pro-inflammatory and pro-fibrotic factors by CCN2/CTGF in H9c2 cardiomyocytes

(2010) Xiaoyu Wang et al.   Journal of Cell Communication and Signaling

Urinary monocyte chemoattractant protein-1 (MCP-1) and connective tissue growth factor (CCN2) as prognostic markers for progression of diabetic nephropathy

(2009) Frederick W.K. Tam et al.   CYTOKINE

Betacellulin Protects From Pancreatitis by Activating Stress-Activated Protein Kinase

(2009) Maik Dahlhoff et al.   GASTROENTEROLOGY

Increased expression of ErbB-2 in liver is associated with hepatitis B × antigen and shorter survival in patients with liver cancer

(2009) Jie Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Periadventitial delivery of anti-EGF receptor antibody inhibits neointimal macrophage accumulation after angioplasty in a hypercholesterolaemic rabbit

(2009) Shahida Shafi et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

CTGF Promotes Inflammatory Cell Infiltration of the Renal Interstitium by Activating NF- B

(2009) E. Sanchez-Lopez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial

(2009) Robert Pirker et al.   LANCET

Connective Tissue Growth Factor-(CTGF, CCN2) – A Marker, Mediator and Therapeutic Target for Renal Fibrosis

(2009) Mysore K. Phanish et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Transforming growth factor α induces angiogenesis and neurogenesis following stroke

(2009) R.R. Leker et al.   NEUROSCIENCE

Screening for Epidermal Growth Factor Receptor Mutations in Lung Cancer

(2009) Rafael Rosell et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gefitinib or Carboplatin–Paclitaxel in Pulmonary Adenocarcinoma

(2009) Tony S. Mok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Connective Tissue Growth Factor Overexpression in Cardiomyocytes Promotes Cardiac Hypertrophy and Protection against Pressure Overload

(2009) Anna N. Panek et al.   PLoS One

Early inhibition of EGFR signaling prevents diabetes-induced up-regulation of multiple gene pathways in the mesenteric vasculature

(2009) Ibrahim F. Benter et al.   VASCULAR PHARMACOLOGY

Connective tissue growth factor (CTGF, CCN2) gene regulation: a potent clinical bio-marker of fibroproliferative disease?

(2009) Andrew Leask et al.   Journal of Cell Communication and Signaling

Induction of Na+/K+/2Cl− cotransporter expression mediates chronic potentiation of intestinal epithelial Cl− secretion by EGF

(2008) Fiona O'Mahony et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

EGF and K+ channel activity control normal and cystic fibrosis bronchial epithelia repair

(2008) Nguyen Thu Ngan Trinh et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Transactivation of epidermal growth factor receptor in vascular and renal systems in rats with experimental hyperleptinemia: Role in leptin-induced hypertension

(2008) Anna Jamroz-Wiśniewska et al.   BIOCHEMICAL PHARMACOLOGY

Hypoxia in Human Trophoblasts Stimulates the Expression and Secretion of Connective Tissue Growth Factor

(2008) Eli Rimon et al.   ENDOCRINOLOGY

Plasma connective tissue growth factor is a novel potential biomarker of cardiac dysfunction in patients with chronic heart failure

(2008) Norimichi Koitabashi et al.   EUROPEAN JOURNAL OF HEART FAILURE

The role of the EGF family of ligands and receptors in renal development, physiology and pathophysiology

(2008) Fenghua Zeng et al.   EXPERIMENTAL CELL RESEARCH

Connective tissue growth factor: Structure–function relationships of a mosaic, multifunctional protein

(2008) Patricia De Winter et al.   GROWTH FACTORS

The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis

(2008) Maria J. Perugorria et al.   HEPATOLOGY

Epidermal Growth Factor Receptor Signaling in the Kidney

(2008) Wynand B.W.H. Melenhorst et al.   HYPERTENSION

UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines

(2008) Bhuminder Singh et al.   INTERNATIONAL JOURNAL OF CANCER

The epidermal growth factor receptor ligands at a glance

(2008) Marlon R. Schneider et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The ADAM metalloproteinases

(2008) D EDWARDS et al.   MOLECULAR ASPECTS OF MEDICINE

BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

(2008) D Li et al.   ONCOGENE

A Novel Accurate Rapid ELISA for Detection of Urinary Connective Tissue Growth Factor, a Biomarker of Chronic Allograft Nephropathy

(2008) J. Bao et al.   TRANSPLANTATION PROCEEDINGS