Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

Mechanisms of Renal Fibrosis

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PINK1-PRKN/PARK2 pathway of mitophagy is activated to protect against renal ischemia-reperfusion injury

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FGF21 is induced in cisplatin nephrotoxicity to protect against kidney tubular cell injury

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Macrophage Uptake of Necrotic Cell DNA Activates the AIM2 Inflammasome to Regulate a Proinflammatory Phenotype in CKD

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Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy

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Renal tubule injury: a driving force toward chronic kidney disease

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Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells

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De novo NAD+ biosynthetic impairment in acute kidney injury in humans

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Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

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Macrophage-to-Myofibroblast Transition Contributes to Interstitial Fibrosis in Chronic Renal Allograft Injury

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Breast Regression Protein–39/Chitinase 3–Like 1 Promotes Renal Fibrosis after Kidney InjuryviaActivation of Myofibroblasts

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Definition of a tolerable upper intake level of niacin: a systematic review and meta-analysis of the dose-dependent effects of nicotinamide and nicotinic acid supplementation

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Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

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Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

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TGF-β: the master regulator of fibrosis

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Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

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Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

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Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD

(2015) David A. Ferenbach et al.   Nature Reviews Nephrology

Inflammatory processes in renal fibrosis

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Nicotinamide treatment reduces the levels of oxidative stress, apoptosis, and PARP-1 activity in Aβ(1–42)-induced rat model of Alzheimer's disease

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The contribution of chronic kidney disease to the global burden of major noncommunicable diseases

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Cellular and molecular mechanisms of renal fibrosis

(2011) Youhua Liu   Nature Reviews Nephrology

Therapeutic benefits of the group B3 vitamin nicotinamide in mice with lethal endotoxemia and polymicrobial sepsis

(2011) Hongmei Yuan et al.   PHARMACOLOGICAL RESEARCH

Fatty liver and fibrosis in glycine N-methyltransferase knockout mice is prevented by nicotinamide

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Sirtuins and Their Relevance to the Kidney

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An integrative view on the role of TGF-β in the progressive tubular deletion associated with chronic kidney disease

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Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

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PARP-1 Inhibits Glycolysis in Ischemic Kidneys

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