WNT–β-catenin signalling — a versatile player in kidney injury and repair

Dickkopf 3—a novel biomarker of the ‘kidney injury continuum’

(2020) Stefan J Schunk et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Tubular β-catenin and FoxO3 interactions protect in chronic kidney disease

(2020) Stellor Nlandu-Khodo et al.   JCI Insight

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration

(2019) Haiyan Fu et al.   KIDNEY INTERNATIONAL

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome

(2019) Yue Zhao et al.   KIDNEY INTERNATIONAL

Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria

(2019) Lili Zhou et al.   KIDNEY INTERNATIONAL

Fibroblast-specific plasminogen activator inhibitor-1 depletion ameliorates renal interstitial fibrosis after unilateral ureteral obstruction

(2019) Lan Yao et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Targeting the crosstalks of Wnt pathway with Hedgehog and Notch for cancer therapy

(2019) Sharmistha Chatterjee et al.   PHARMACOLOGICAL RESEARCH

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

(2019) Jinhua Miao et al.   AGING CELL

Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis

(2019) Xiaohan Lu et al.   KIDNEY INTERNATIONAL

Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study

(2019) Stefan J Schunk et al.   LANCET

Evaluation of the association of Wnt signaling with coronary artery calcification in patients on dialysis with severe secondary hyperparathyroidism

(2019) Tzung-Yo Ho et al.   BMC Nephrology

Urinary Matrix Metalloproteinase 7 and Prediction of IgA Nephropathy Progression

(2019) Xiaobing Yang et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

TRPC Channels in Proteinuric Kidney Diseases

(2019) Gentzon Hall et al.   Cells

Binding of Dickkopf-3 to CXCR7 Enhances Vascular Progenitor Cell Migration and Degradable Graft Regeneration

(2018) Shirin Issa Bhaloo et al.   CIRCULATION RESEARCH

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells

(2018) Congwei Luo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fibroblast-Specificβ-Catenin Signaling Dictates the Outcome of AKI

(2018) Dong Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria

(2018) Dickson W.L. Wong et al.   KIDNEY INTERNATIONAL

Dickkopf-3 in aberrant endothelial secretome triggers renal fibroblast activation and endothelial–mesenchymal transition

(2018) Mark Lipphardt et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Indoxyl sulfate accelerates vascular smooth muscle cell calcification via microRNA-29b dependent regulation of Wnt/β-catenin signaling

(2018) Han Zhang et al.   TOXICOLOGY LETTERS

Inhibition of PAI-1 attenuates perirenal fat inflammation and the associated nephropathy in high-fat diet-induced obese mice

(2018) Yong Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

(2018) Ye Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tenascin-C protects against acute kidney injury by recruiting Wnt ligands

(2018) Shuangqin Chen et al.   KIDNEY INTERNATIONAL

Polycystic kidney disease

(2018) Carsten Bergmann et al.   Nature Reviews Disease Primers

Redirecting TGF-βSignaling through theβ-Catenin/Foxo Complex Prevents Kidney Fibrosis

(2017) Xi Qiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery

(2017) Xiaobing Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Sorting Nexin 3 Retromer Pathway Regulates the Cell Surface Localization and Activity of a Wnt-Activated Polycystin Channel Complex

(2017) Shuang Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blocking TGF-βandβ-Catenin Epithelial Crosstalk Exacerbates CKD

(2017) Stellor Nlandu-Khodo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

(Pro)renin Receptor Is an Amplifier of Wnt/ β -Catenin Signaling in Kidney Injury and Fibrosis

(2017) Zhen Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis

(2017) Dong Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Connective Tissue Growth Factor Domain 4 Amplifies Fibrotic Kidney Disease through Activation of LDL Receptor–Related Protein 6

(2017) Bryce G. Johnson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ β -Catenin–Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis

(2017) Ye Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pigment epithelium-derived factor, a noninhibitory serine protease inhibitor, is renoprotective by inhibiting the Wnt pathway

(2017) Xuemin He et al.   KIDNEY INTERNATIONAL

Romosozumab (sclerostin monoclonal antibody) versus teriparatide in postmenopausal women with osteoporosis transitioning from oral bisphosphonate therapy: a randomised, open-label, phase 3 trial

(2017) Bente L Langdahl et al.   LANCET

The systemic nature of CKD

(2017) Carmine Zoccali et al.   Nature Reviews Nephrology

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

(2017) Kenneth G. Saag et al.   NEW ENGLAND JOURNAL OF MEDICINE

Role of Noncanonical Wnt Signaling Pathway in Human Aortic Valve CalcificationHighlights

(2016) Isabella Albanese et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Wnt signaling contributes to vascular calcification by induction of matrix metalloproteinases

(2016) Christian Freise et al.   BMC Cardiovascular Disorders

Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis

(2016) Rui Cheng et al.   DIABETES

WNT/β-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression

(2016) Ting Cai et al.   EXPERIMENTAL CELL RESEARCH

Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis

(2016) Dong Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ligand trap for the activin type IIA receptor protects against vascular disease and renal fibrosis in mice with chronic kidney disease

(2016) Olga A. Agapova et al.   KIDNEY INTERNATIONAL

Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis

(2016) Babita Madan et al.   KIDNEY INTERNATIONAL

Direct inhibition of osteoblastic Wnt pathway by fibroblast growth factor 23 contributes to bone loss in chronic kidney disease

(2016) Natalia Carrillo-López et al.   KIDNEY INTERNATIONAL

The polycystin complex mediates Wnt/Ca2+ signalling

(2016) Seokho Kim et al.   NATURE CELL BIOLOGY

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

(2016) Felicia Cosman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Making, Exporting, and Modulating Wnts

(2016) Paul F. Langton et al.   TRENDS IN CELL BIOLOGY

Downregulation of renal tubular Wnt/β-catenin signaling by Dickkopf-3 induces tubular cell death in proteinuric nephropathy

(2016) D W L Wong et al.   Cell Death & Disease

Wnt-Frizzled/Planar Cell Polarity Signaling: Cellular Orientation by Facing the Wind (Wnt)

(2015) Yingzi Yang et al.   Annual Review of Cell and Developmental Biology

Anti-DKK1 antibody promotes bone fracture healing through activation of β-catenin signaling

(2015) Hongting Jin et al.   BONE

Insights into the Mechanisms Involved in the Expression and Regulation of Extracellular Matrix Proteins in Diabetic Nephropathy

(2015) C. Hu et al.   CURRENT MEDICINAL CHEMISTRY

Systemic administration of sclerostin monoclonal antibody accelerates fracture healing in the femoral osteotomy model of young rats

(2015) Gao Feng et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Effect of Remote Ischemic Preconditioning on Kidney Injury Among High-Risk Patients Undergoing Cardiac Surgery

(2015) Alexander Zarbock et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Anti-Sclerostin Antibody Treatment in a Rat Model of Progressive Renal Osteodystrophy

(2015) Sharon M Moe et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Gq signaling causes glomerular injury by activating TRPC6

(2015) Liming Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Four-and-a-Half LIM Domains Protein 2 Is a Coactivator of Wnt Signaling in Diabetic Kidney Disease

(2015) S.-Y. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk

(2015) O. H. Maarouf et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword

(2015) Dong Zhou et al.   LABORATORY INVESTIGATION

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

(2015) Lili Zhou et al.   Nature Reviews Nephrology

Circulating Wnt/β-catenin signalling inhibitors and uraemic vascular calcifications

(2015) Chih-Yu Yang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Intensive Supportive Care plus Immunosuppression in IgA Nephropathy

(2015) Thomas Rauen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Filopodia-based Wnt transport during vertebrate tissue patterning

(2015) Eliana Stanganello et al.   Nature Communications

Antagonism of Canonical Wnt/ -Catenin Signaling: Taking RAS Blockade to the Next Level?

(2014) J. Floege   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

CKD-Induced Wingless/Integration1 Inhibitors and Phosphorus Cause the CKD-Mineral and Bone Disorder

(2014) Y. Fang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Multiple Genes of the Renin-Angiotensin System Are Novel Targets of Wnt/ -Catenin Signaling

(2014) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Romosozumab in Postmenopausal Women with Low Bone Mineral Density

(2014) Michael R. McClung et al.   NEW ENGLAND JOURNAL OF MEDICINE

High Glucose Induces Podocyte Injury via Enhanced (Pro)renin Receptor-Wnt-β-Catenin-Snail Signaling Pathway

(2014) Caixia Li et al.   PLoS One

The Osteocyte: An Endocrine Cell … and More

(2013) Sarah L. Dallas et al.   ENDOCRINE REVIEWS

Activation of Wnt5a-Ror2 signaling associated with epithelial-to-mesenchymal transition of tubular epithelial cells during renal fibrosis

(2013) Xin Li et al.   GENES TO CELLS

Calmodulin-dependent Protein Kinase II/cAMP Response Element-binding Protein/Wnt/β-Catenin Signaling Cascade Regulates Angiotensin II-induced Podocyte Injury and Albuminuria

(2013) Lei Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wnt4/ -Catenin Signaling in Medullary Kidney Myofibroblasts

(2013) D. P. DiRocco et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of Klotho Contributes to Kidney Injury by Derepression of Wnt/ -Catenin Signaling

(2013) L. Zhou et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Planar cell polarity and the kidney

(2013) E. Papakrivopoulou et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

LRP-6 is a coreceptor for multiple fibrogenic signaling pathways in pericytes and myofibroblasts that are inhibited by DKK-1

(2013) Shuyu Ren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

(2013) Dong Zhou et al.   Scientific Reports

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Targeting the Fas/FasL signaling pathway in cancer therapy

(2012) María Villa-Morales et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Activation of Wnt11 by Transforming Growth Factor-β Drives Mesenchymal Gene Expression through Non-canonical Wnt Protein Signaling in Renal Epithelial Cells

(2012) Peng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repression of osteocyte Wnt/β-catenin signaling is an early event in the progression of renal osteodystrophy

(2012) Yves Sabbagh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

(2012) Dong Zhou et al.   KIDNEY INTERNATIONAL

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

LRP5 and LRP6 in development and disease

(2012) Danese M. Joiner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Dissecting the Wnt secretion pathway: key questions on the modification and intracellular trafficking of Wnt proteins

(2011) M. Harterink et al.   Acta Physiologica

Wnt/β-Catenin Pathway in Podocytes Integrates Cell Adhesion, Differentiation, and Survival

(2011) Hideki Kato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix Metalloproteinase-7 as a Surrogate Marker Predicts Renal Wnt/ -Catenin Activity in CKD

(2011) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prorenin Receptor Is Essential for Podocyte Autophagy and Survival

(2011) F. Riediger et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Inhibition of  -Catenin/CBP Signaling Ameliorates Renal Interstitial Fibrosis

(2011) S. Hao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria

(2011) Dan Wang et al.   KIDNEY INTERNATIONAL

Reversible cell-cycle entry in adult kidney podocytes through regulated control of telomerase and Wnt signaling

(2011) Marina Shkreli et al.   NATURE MEDICINE

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

(2011) Tomas Malinauskas et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

(2011) Asiri R. Wijenayaka et al.   PLoS One

Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility

(2011) K. A. Mulligan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of Wnt Signaling by Dkk1 Attenuates PTH-Mediated Stromal Cell Response and New Bone Formation

(2010) Jun Guo et al.   Cell Metabolism

Regulation of Lrp6 phosphorylation

(2010) Christof Niehrs et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The (Pro)renin Receptor/ATP6AP2 is Essential for Vacuolar H + -ATPase Assembly in Murine Cardiomyocytes

(2010) Kenichiro Kinouchi et al.   CIRCULATION RESEARCH

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genetic Variation of DKK3 May Modify Renal Disease Severity in ADPKD

(2010) M. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Blockade of Wnt/ -Catenin Signaling by Paricalcitol Ameliorates Proteinuria and Kidney Injury

(2010) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells

(2009) Hideaki Nakajima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Sailing with the Wnt: Charting the Wnt processing and secretion route

(2009) Magdalena J. Lorenowicz et al.   EXPERIMENTAL CELL RESEARCH

 -Catenin Promotes Survival of Renal Epithelial Cells by Inhibiting Bax

(2009) Z. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dickkopf-1 Promotes Hyperglycemia-Induced Accumulation of Mesangial Matrix and Renal Dysfunction

(2009) C.-L. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Podocyte Dysfunction and Albuminuria

(2009) C. Dai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

(2009) W. He et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt9b signaling regulates planar cell polarity and kidney tubule morphogenesis

(2009) Courtney M Karner et al.   NATURE GENETICS

Impaired Wnt–β-catenin signaling disrupts adult renal homeostasis and leads to cystic kidney ciliopathy

(2009) Madeline A Lancaster et al.   NATURE MEDICINE

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH