Improved understanding of biorisk for research involving microbial modification using annotated sequences of concern

SARS-CoV-2 membrane protein causes the mitochondrial apoptosis and pulmonary edema via targeting BOK

(2022) Yang Yang et al.   CELL DEATH AND DIFFERENTIATION

SARS-CoV-2 accessory protein ORF8 is secreted extracellularly as a glycoprotein homodimer

(2022) Kazuhiro Matsuoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coronaviruses Nsp5 Antagonizes Porcine Gasdermin D-Mediated Pyroptosis by Cleaving Pore-Forming p30 Fragment

(2022) Fushan Shi et al.   mBio

SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection

(2022) Xiaolin Zhang et al.   Autophagy

SARS-CoV-2 Nucleocapsid Protein Targets a Conserved Surface Groove of the NTF2-like Domain of G3BP1

(2022) Mahamaya Biswal et al.   JOURNAL OF MOLECULAR BIOLOGY

SARS-CoV-2 ORF6 disrupts nucleocytoplasmic trafficking to advance viral replication

(2022) Yoichi Miyamoto et al.   Communications Biology

Function-based classification of hazardous biological sequences: Demonstration of a new paradigm for biohazard assessments

(2022) Bryan T. Gemler et al.   Frontiers in Bioengineering and Biotechnology

The SARS-CoV-2 nucleocapsid phosphoprotein forms mutually exclusive condensates with RNA and the membrane-associated M protein

(2021) Shan Lu et al.   Nature Communications

SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocation

(2021) Wenjing Wang et al.   Cellular & Molecular Immunology

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

(2021) Chris A. Brosey et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO

(2021) Jing Wu et al.   Cell Reports

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

(2021) Ke Zhang et al.   Science Advances

SARS-CoV-2 Nucleocapsid Protein Targets RIG-I-Like Receptor Pathways to Inhibit the Induction of Interferon Response

(2021) Soo Jin Oh et al.   Cells

Title: ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway

(2021) Xiaoyuan Lin et al.   iScience

SARS‐CoV‐2 ORF9b antagonizes type I and III interferons by targeting multiple components of the RIG‐I/MDA‐5–MAVS, TLR3–TRIF, and cGAS–STING signaling pathways

(2021) Lulu Han et al.   JOURNAL OF MEDICAL VIROLOGY

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia

(2021) Luca Braga et al.   NATURE

SARS-CoV-2 uses a multipronged strategy to impede host protein synthesis

(2021) Yaara Finkel et al.   NATURE

SARS-CoV-2 ORF6 Disrupts Bidirectional Nucleocytoplasmic Transport through Interactions with Rae1 and Nup98

(2021) Amin Addetia et al.   mBio

SARS-CoV-2 gene content and COVID-19 mutation impact by comparing 44 Sarbecovirus genomes

(2021) Irwin Jungreis et al.   Nature Communications

SARS-CoV-2 Membrane Protein Inhibits Type I Interferon Production Through Ubiquitin-Mediated Degradation of TBK1

(2021) Liyan Sui et al.   Frontiers in Immunology

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

(2021) Marion Schuller et al.   Science Advances

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

(2021) Yabin Zhang et al.   Cell Discovery

Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90

(2021) Lukas Brandherm et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of clinical isolate or cleavage site mutations in the SARS-CoV-2 spike protein on protein stability, cleavage, and cell–cell fusion

(2021) Chelsea T. Barrett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

(2021) Lilian Cristina Russo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

(2021) Shuai Wang et al.   NATURE CELL BIOLOGY

SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

(2021) Christine Vazquez et al.   PLoS One

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

(2021) Jack Chun-Chieh Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

(2021) Yiwen Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a High-Frequency Intrahost SARS-CoV-2 Spike Variant with Enhanced Cytopathic and Fusogenic Effects

(2021) Lynda Rocheleau et al.   mBio

SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response

(2021) Yongzhen Liu et al.   mBio

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

(2021) Caterina Prelli Bozzo et al.   Nature Communications

SARS-CoV-2 suppresses IFNβ production mediated by NSP1, 5, 6, 15, ORF6 and ORF7b but does not suppress the effects of added interferon

(2021) Maya Shemesh et al.   PLoS Pathogens

Toxoplasma gondii Type-I ROP18 Targeting Human E3 Ligase TRIM21 for Immune Escape

(2021) Lijie Yao et al.   Frontiers in Cell and Developmental Biology

TNF Decoy Receptors Encoded by Poxviruses

(2021) Francisco Javier Alvarez-de Miranda et al.   Pathogens

Clinical Strains of Pseudomonas aeruginosa Secrete LasB Elastase to Induce Hemorrhagic Diffuse Alveolar Damage in Mice

(2021) Yajie Zhu et al.   Journal of Inflammation Research

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egress

(2021) Di Chen et al.   DEVELOPMENTAL CELL

Categorizing sequences of concern by function to better assess mechanisms of microbial pathogenesis

(2021) Gene D. Godbold et al.   INFECTION AND IMMUNITY

SARS-CoV-2 spike engagement of ACE2 primes S2′ site cleavage and fusion initiation

(2021) Shi Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

SARS-CoV-2 ORF3a Induces Incomplete Autophagy via the Unfolded Protein Response

(2021) Wen-qing Su et al.   Viruses-Basel

SARS-CoV-2 spike protein induces inflammation via TLR2-dependent activation of the NF-κB pathway

(2021) Shahanshah Khan et al.   eLife

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Membrane (M) and Spike (S) Proteins Antagonize Host Type I Interferon Response

(2021) Qi Zhang et al.   Frontiers in Cellular and Infection Microbiology

ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1

(2021) Rong Wang et al.   Frontiers in Microbiology

SARS-CoV-2 Spike Protein and Its Receptor Binding Domain Promote a Proinflammatory Activation Profile on Human Dendritic Cells

(2021) Dante Barreda et al.   Cells

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

(2020) Alexandra C. Walls et al.   CELL

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

(2020) David E. Gordon et al.   NATURE

Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: a report of five cases

(2020) Cynthia Magro et al.   Translational Research

Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways

(2020) Masmudur M. Rahman et al.   Vaccines

SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70

(2020) He-wei Jiang et al.   Cellular & Molecular Immunology

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity

(2020) Donghyuk Shin et al.   NATURE

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

(2020) Matthias Thoms et al.   SCIENCE

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

SARS-CoV-2 Molecular Network Structure

(2020) José Díaz   Frontiers in Physiology

Lost in deletion: The enigmatic ORF8 protein of SARS-CoV-2

(2020) Luca Zinzula   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Syncytia formation by SARS‐CoV‐2 infected cells

(2020) Julian Buchrieser et al.   EMBO JOURNAL

Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2

(2020) Theresa Klemm et al.   EMBO JOURNAL

The Mitochondrial Outer Membrane Protein Tom70-Mediator in Protein Traffic, Membrane Contact Sites and Innate Immunity

(2020) Sebastian Kreimendahl et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The NSs protein encoded by the virulent strain of Rift Valley fever virus targets the expression of Abl2 and the actin cytoskeleton of the host affecting cell mobility, cell shape and cell-cell adhesion

(2020) Aline Bamia et al.   JOURNAL OF VIROLOGY

SARS-CoV-2 Nsp1 binds the ribosomal mRNA channel to inhibit translation

(2020) Katharina Schubert et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Neuropilin-1 is a host factor for SARS-CoV-2 infection

(2020) James L. Daly et al.   SCIENCE

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity

(2020) Ludovico Cantuti-Castelvetri et al.   SCIENCE

The ORF6, ORF8 and nucleocapsid proteins of SARS-CoV-2 inhibit type I interferon signaling pathway

(2020) Jin-Yan Li et al.   VIRUS RESEARCH

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

Flexible, Functional, and Familiar: Characteristics of SARS-CoV-2 Spike Protein Evolution

(2020) Dianita S. Saputri et al.   Frontiers in Microbiology

In the Crosshairs: RNA Viruses OR Complement?

(2020) Nisha Asok Kumar et al.   Frontiers in Immunology

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

(2020) Josh Sun et al.   EBioMedicine

SARS-CoV-2 N protein antagonizes type I interferon signaling by suppressing phosphorylation and nuclear translocation of STAT1 and STAT2

(2020) Jingfang Mu et al.   Cell Discovery

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Comparative insight into the genomic landscape of SARS‐CoV‐2 and identification of mutations associated with the origin of infection and diversity

(2020) Divya Mishra et al.   JOURNAL OF MEDICAL VIROLOGY

The Gene Ontology resource: enriching a GOld mine

(2020) et al.   NUCLEIC ACIDS RESEARCH

SARS-CoV-2 proteases PLpro and 3CLpro cleave IRF3 and critical modulators of inflammatory pathways (NLRP12 and TAB1): implications for disease presentation across species.

(2020) Mehdi Moustaqil et al.   Emerging Microbes & Infections

N-terminal degradation activates the NLRP1B inflammasome

(2019) Ashley J. Chui et al.   SCIENCE

Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells

(2019) Liang Tao et al.   Nature Microbiology

REV7 has a dynamic adaptor region to accommodate small GTPase RAN/Shigella IpaB ligands, and its activity is regulated by the RanGTP/GDP switch

(2019) Xin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A

(2018) Cason R. King et al.   mBio

Genome-Wide Bimolecular Fluorescence Complementation-Based Proteomic Analysis of Toxoplasma gondii ROP18’s Human Interactome Shows Its Key Role in Regulation of Cell Immunity and Apoptosis

(2018) Jing Xia et al.   Frontiers in Immunology

Histophilus somni Survives in Bovine Macrophages by Interfering with Phagosome-Lysosome Fusion, but Requires IbpA for Optimal Serum Resistance

(2018) Yu Pan et al.   INFECTION AND IMMUNITY

Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation

(2018) Fabien Bastaert et al.   Frontiers in Immunology

Specificity and functional interplay between influenza virus PA-X and NS1 shutoff activity

(2018) Chutikarn Chaimayo et al.   PLoS Pathogens

A Human Proteome Array Approach to Identifying Key Host Proteins Targeted byToxoplasmaKinase ROP18

(2017) Zhaoshou Yang et al.   MOLECULAR & CELLULAR PROTEOMICS

Pseudomonas aeruginosaLasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator–IL-6–antimicrobial–repair pathway

(2017) Vinciane Saint-Criq et al.   THORAX

Myxoma Virus dsRNA Binding Protein M029 Inhibits the Type I IFN‐Induced Antiviral State in a Highly Species‐Specific Fashion

(2017) Masmudur Rahman et al.   Viruses-Basel

Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

(2016) Maria Anastasina et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Bacillus anthracis S-layer protein BslA binds to extracellular matrix by interacting with laminin

(2016) Yanchun Wang et al.   BMC MICROBIOLOGY

Glucosylation Drives the Innate Inflammatory Response to Clostridium difficile Toxin A

(2016) Carrie A. Cowardin et al.   INFECTION AND IMMUNITY

Identification of a Substrate-selective Exosite within the Metalloproteinase Anthrax Lethal Factor

(2016) Allison B. Goldberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR

(2016) Markus Kainulainen et al.   JOURNAL OF VIROLOGY

Toxoplasma gondii ROP18: potential to manipulate host cell mitochondrial apoptosis

(2016) Liang Wu et al.   PARASITOLOGY RESEARCH

Mechanistic Insight into the Host Transcription Inhibition Function of Rift Valley Fever Virus NSs and Its Importance in Virulence

(2016) Kaori Terasaki et al.   PLoS Neglected Tropical Diseases

Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence

(2016) Yanyu Wang et al.   PLoS Pathogens

The Ins and Outs of Anthrax Toxin

(2016) Sarah Friebe et al.   Toxins

The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2

(2016) Florian Glenewinkel et al.   Scientific Reports

What is infectiveness and how is it involved in infection and immunity?

(2015) Liise-anne Pirofski et al.   BMC IMMUNOLOGY

The roles of the virulence factor IpaB in Shigella spp. in the escape from immune cells and invasion of epithelial cells

(2015) Shih-Chun Yang et al.   MICROBIOLOGICAL RESEARCH

Human genetic basis of interindividual variability in the course of infection

(2015) Jean-Laurent Casanova   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Severe infectious diseases of childhood as monogenic inborn errors of immunity

(2015) Jean-Laurent Casanova   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

(2015) L. Lau et al.   SCIENCE

A fungal protease allergen provokes airway hyper-responsiveness in asthma

(2015) Nariman A. Balenga et al.   Nature Communications

Lethal Factor, but Not Edema Factor, Is Required to Cause Fatal Anthrax in Cynomolgus Macaques after Pulmonary Spore Challenge

(2014) Julie A. Hutt et al.   AMERICAN JOURNAL OF PATHOLOGY

Heterologous Expression of Bartonella Adhesin A in Escherichia coli by Exchange of Trimeric Autotransporter Adhesin Domains Results in Enhanced Adhesion Properties and a Pathogenic Phenotype

(2014) T. Schmidgen et al.   JOURNAL OF BACTERIOLOGY

Toxoplasma gondiiVirulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation

(2014) Jian Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virulence Factor NSs of Rift Valley Fever Virus Recruits the F-Box Protein FBXO3 To Degrade Subunit p62 of General Transcription Factor TFIIH

(2014) M. Kainulainen et al.   JOURNAL OF VIROLOGY

A Natural Genetic Variant of Granzyme B Confers Lethality to a Common Viral Infection

(2014) Christopher E. Andoniou et al.   PLoS Pathogens

VE-Cadherin Cleavage by LasB Protease from Pseudomonas aeruginosa Facilitates Type III Secretion System Toxicity in Endothelial Cells

(2014) Guillaume Golovkine et al.   PLoS Pathogens

Key tissue targets responsible for anthrax-toxin-induced lethality

(2013) Shihui Liu et al.   NATURE

Shigella Effector IpaB-Induced Cholesterol Relocation Disrupts the Golgi Complex and Recycling Network to Inhibit Host Cell Secretion

(2012) Joëlle Mounier et al.   Cell Host & Microbe

Adenovirus Evasion of Interferon-Mediated Innate Immunity by Direct Antagonism of a Cellular Histone Posttranslational Modification

(2012) G.J. Fonseca et al.   Cell Host & Microbe

Bacillus anthracis protease InhA regulates BslA-mediated adhesion in human endothelial cells

(2012) Jessica H. Tonry et al.   CELLULAR MICROBIOLOGY

Bacillus anthracis Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function

(2012) Marybeth Langer et al.   INFECTION AND IMMUNITY

A survey of host range genes in poxvirus genomes

(2012) Kirsten A. Bratke et al.   INFECTION GENETICS AND EVOLUTION

Induction of DNA Damage Signaling upon Rift Valley Fever Virus Infection Results in Cell Cycle Arrest and Increased Viral Replication

(2012) Alan Baer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Binding and cell intoxication studies of anthrax lethal toxin

(2012) Momchilo Vuyisich et al.   MOLECULAR BIOLOGY REPORTS

Functional Analysis of Rift Valley Fever Virus NSs Encoding a Partial Truncation

(2012) Jennifer A. Head et al.   PLoS One

Spontaneous formation of IpaB ion channels in host cell membranes reveals how Shigella induces pyroptosis in macrophages

(2012) L Senerovic et al.   Cell Death & Disease

The thermolysin-like metalloproteinase and virulence factor LasB from pathogenic Pseudomonas aeruginosa induces anoikis of human vascular cells

(2011) Nathalie Beaufort et al.   CELLULAR MICROBIOLOGY

In Vivo-Induced InvA-Like Autotransporters Ifp and InvC of Yersinia pseudotuberculosis Promote Interactions with Intestinal Epithelial Cells and Contribute to Virulence

(2011) Fabio Pisano et al.   INFECTION AND IMMUNITY

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bacillus anthracis Protease InhA Increases Blood-Brain Barrier Permeability and Contributes to Cerebral Hemorrhages

(2011) Dhritiman V. Mukherjee et al.   PLoS One

Adenovirus E1A interacts directly with, and regulates the level of expression of, the immunoproteasome component MECL1

(2011) Sarah Berhane et al.   VIROLOGY

SARS Coronavirus nsp1 Protein Induces Template-Dependent Endonucleolytic Cleavage of mRNAs: Viral mRNAs Are Resistant to nsp1-Induced RNA Cleavage

(2011) Cheng Huang et al.   PLoS Pathogens

The role of anthrolysin O in gut epithelial barrier disruption during Bacillus anthracis infection

(2010) Brian L. Bishop et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome

(2010) Jeffrey Ng et al.   GASTROENTEROLOGY

The Extreme C Terminus of Shigella flexneri IpaB Is Required for Regulation of Type III Secretion, Needle Tip Composition, and Binding

(2010) A. D. Roehrich et al.   INFECTION AND IMMUNITY

Histophilus somni IbpA DR2/Fic in Virulence and Immunoprotection at the Natural Host Alveolar Epithelial Barrier

(2010) B. Zekarias et al.   INFECTION AND IMMUNITY

Secreted Aspergillus fumigatus Protease Alp1 Degrades Human Complement Proteins C3, C4, and C5

(2010) J. Behnsen et al.   INFECTION AND IMMUNITY

The N Terminus of Adenovirus Type 12 E1A Inhibits Major Histocompatibility Complex Class I Expression by Preventing Phosphorylation of NF- B p65 Ser276 through Direct Binding

(2010) J. Jiao et al.   JOURNAL OF VIROLOGY

Chemokine-cleaving Streptococcus pyogenes protease SpyCEP is necessary and sufficient for bacterial dissemination within soft tissues and the respiratory tract

(2010) Prathiba Kurupati et al.   MOLECULAR MICROBIOLOGY

Viruses' backup plan

(2010) Kevin M. Ryan   NATURE

Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst

(2010) Annabel Guichard et al.   NATURE

Clostridial Glucosylating Toxins Enter Cells via Clathrin-Mediated Endocytosis

(2010) Panagiotis Papatheodorou et al.   PLoS One

Transit through the Flea Vector Induces a Pretransmission Innate Immunity Resistance Phenotype in Yersinia pestis

(2010) Viveka Vadyvaloo et al.   PLoS Pathogens

Influenza A Virus NS1 Targets the Ubiquitin Ligase TRIM25 to Evade Recognition by the Host Viral RNA Sensor RIG-I

(2009) Michaela Ulrike Gack et al.   Cell Host & Microbe

Penetration of the Blood-Brain Barrier by Bacillus anthracis Requires the pXO1-Encoded BslA Protein

(2009) C. M. Ebrahimi et al.   JOURNAL OF BACTERIOLOGY

Staphylococcus aureussynthesizes adenosine to escape host immune responses

(2009) Vilasack Thammavongsa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ClpX Contributes to Innate Defense Peptide Resistance and Virulence Phenotypes of Bacillus anthracis

(2009) Shauna M. McGillivray et al.   Journal of Innate Immunity

BslA, the S-layer adhesin ofB. anthracis, is a virulence factor for anthrax pathogenesis

(2009) Justin Kern et al.   MOLECULAR MICROBIOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

The IpaC Carboxyterminal Effector Domain Mediates Src-Dependent Actin Polymerization during Shigella Invasion of Epithelial Cells

(2009) Joëlle Mounier et al.   PLoS Pathogens

Molecular Pathogenesis of Shigella spp.: Controlling Host Cell Signaling, Invasion, and Death by Type III Secretion

(2008) G. N. Schroeder et al.   CLINICAL MICROBIOLOGY REVIEWS

Four Superoxide Dismutases Contribute to Bacillus anthracis Virulence and Provide Spores with Redundant Protection from Oxidative Stress

(2008) R. J. Cybulski et al.   INFECTION AND IMMUNITY

Anthrax Toxins Inhibit Neutrophil Signaling Pathways in Brain Endothelium and Contribute to the Pathogenesis of Meningitis

(2008) Nina M. van Sorge et al.   PLoS One

A SAP30 Complex Inhibits IFN-β Expression in Rift Valley Fever Virus Infected Cells

(2008) Nicolas Le May et al.   PLoS Pathogens