A Human Proteome Array Approach to Identifying Key Host Proteins Targeted byToxoplasmaKinase ROP18

Mitotic Checkpoint Regulators Control Insulin Signaling and Metabolic Homeostasis

(2016) Eunhee Choi et al.   CELL

Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production

(2016) Paul M. Titchenell et al.   Cell Metabolism

The characterisation of LATS2 kinase regulation in Hippo-YAP signalling

(2016) Lily Hoa et al.   CELLULAR SIGNALLING

Three-year retrospective analysis of the incidence of Toxoplasma gondii infection in pregnant women living in the Greater Romagna Area (northeastern Italy)

(2016) P. Billi et al.   CLINICAL MICROBIOLOGY AND INFECTION

TGF-β in Toxoplasmosis: Friend or foe?

(2016) Mohammad Zare-Bidaki et al.   CYTOKINE

Moraxella catarrhalis decreases antiviral innate immune responses by down-regulation of TLR3 via inhibition of p53 in human bronchial epithelial cells

(2016) Annina Heinrich et al.   FASEB JOURNAL

Afatinib Reduces STAT6 Signaling of Host ARPE-19 Cells Infected with Toxoplasma gondii

(2016) Zhaoshou Yang et al.   KOREAN JOURNAL OF PARASITOLOGY

Seroprevalence of Toxoplasma gondii Infection among HIV/AIDS Patients in Eastern China

(2016) Guoqiang Shen et al.   KOREAN JOURNAL OF PARASITOLOGY

Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation

(2016) Laura A Shaw et al.   NATURE IMMUNOLOGY

Toxoplasma gondii ROP18: potential to manipulate host cell mitochondrial apoptosis

(2016) Liang Wu et al.   PARASITOLOGY RESEARCH

Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis

(2016) Sugong Chen et al.   Oncotarget

Metabolomic Profiling of Mice Serum during Toxoplasmosis Progression Using Liquid Chromatography-Mass Spectrometry

(2016) Chun-Xue Zhou et al.   Scientific Reports

Proteomic Profiling of Mouse Liver following Acute Toxoplasma gondii Infection

(2016) Jun-Jun He et al.   PLoS One

Cutting Edge: IFN-γ Produced by Brain-Resident Cells Is Crucial To Control Cerebral Infection withToxoplasma gondii

(2015) Qila Sa et al.   JOURNAL OF IMMUNOLOGY

A Screen for Extracellular Signal-Regulated Kinase-Primed Glycogen Synthase Kinase 3 Substrates Identifies the p53 Inhibitor iASPP

(2015) Crystal Woodard et al.   JOURNAL OF VIROLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Intracellular Networks of the PI3K/AKT and MAPK Pathways for Regulating Toxoplasma gondii-Induced IL-23 and IL-12 Production in Human THP-1 Cells

(2015) Juan-Hua Quan et al.   PLoS One

p53 Degradation by a Coronavirus Papain-like Protease Suppresses Type I Interferon Signaling

(2014) Lin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toxoplasma gondiiVirulence Factor ROP18 Inhibits the Host NF-κB Pathway by Promoting p65 Degradation

(2014) Jian Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β1, but Not Bone Morphogenetic Proteins, Activates Smad1/5 Pathway in Primary Human Macrophages and Induces Expression of Proatherogenic Genes

(2014) Dinara Nurgazieva et al.   JOURNAL OF IMMUNOLOGY

The Endoplasmic Reticulum Adaptor Protein ERAdP Initiates NK Cell Activation via the Ubc13-Mediated NF-κB Pathway

(2014) Jun Chen et al.   JOURNAL OF IMMUNOLOGY

Effects of soluble extracts from Leishmania infantum promastigotes, Toxoplasma gondii tachyzoites on TGF-β mediated pathways in activated CD4+ T lymphocytes

(2014) Ann Maria Clemente et al.   MICROBES AND INFECTION

Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease

(2014) Masaki Miyazaki et al.   NATURE IMMUNOLOGY

STRING v10: protein–protein interaction networks, integrated over the tree of life

(2014) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways

(2014) J Cheng et al.   Cell Death & Disease

Global analysis of phosphorylation networks in humans

(2013) Jianfei Hu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

PhosphoNetworks: a database for human phosphorylation networks

(2013) J. Hu et al.   BIOINFORMATICS

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

Enhancement of protective immune response to recombinant Toxoplasma gondii ROP18 antigen by ginsenoside Re

(2013) Daofeng Qu et al.   EXPERIMENTAL PARASITOLOGY

Structure of theToxoplasma gondiiROP18 Kinase Domain Reveals a Second Ligand Binding Pocket Required for Acute Virulence

(2013) Daniel Lim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Protein Microarray Characterization of theS-Nitrosoproteome

(2013) Yun-Il Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Construction of human activity-based phosphorylation networks

(2013) R. H. Newman et al.   Molecular Systems Biology

Toxoplasma gondii Proliferation Require Down-Regulation of Host Nox4 Expression via Activation of PI3 Kinase/Akt Signaling Pathway

(2013) Wei Zhou et al.   PLoS One

Profiling the Dynamics of a Human Phosphorylome Reveals New Components in HGF/c-Met Signaling

(2013) Crystal L. Woodard et al.   PLoS One

Interactions between the ROP18 kinase and host cell proteins that aid in the parasitism of Toxoplasma gondii

(2012) Li Cheng et al.   ACTA TROPICA

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondii

(2012) James I. MacRae et al.   Cell Host & Microbe

The arginine-rich N-terminal domain of ROP18 is necessary for vacuole targeting and virulence ofToxoplasma gondii

(2012) Sarah J. Fentress et al.   CELLULAR MICROBIOLOGY

Transcriptional Regulator Id2 Is Required for the CD4 T Cell Immune Response in the Development of Experimental Autoimmune Encephalomyelitis

(2012) Y.-Y. Lin et al.   JOURNAL OF IMMUNOLOGY

Rapid Identification of Monospecific Monoclonal Antibodies Using a Human Proteome Microarray

(2012) Jun Seop Jeong et al.   MOLECULAR & CELLULAR PROTEOMICS

The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response

(2012) Takahito Sanada et al.   NATURE

p53 Regulates Neural Stem Cell Proliferation and Differentiation via BMP-Smad1 Signaling and Id1

(2012) Huijuan Liu et al.   STEM CELLS AND DEVELOPMENT

Phosphorylation of the Chromatin Binding Domain of KSHV LANA

(2012) Crystal Woodard et al.   PLoS Pathogens

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Conserved Herpesvirus Kinases Target the DNA Damage Response Pathway and TIP60 Histone Acetyltransferase to Promote Virus Replication

(2011) Renfeng Li et al.   Cell Host & Microbe

ATF6β is a host cellular target of theToxoplasma gondiivirulence factor ROP18

(2011) Masahiro Yamamoto et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The transcriptional regulators Id2 and Id3 control the formation of distinct memory CD8+ T cell subsets

(2011) Cliff Y Yang et al.   NATURE IMMUNOLOGY

Phosphorylation of Immunity-Related GTPases by a Toxoplasma gondii-Secreted Kinase Promotes Macrophage Survival and Virulence

(2010) Sarah J. Fentress et al.   Cell Host & Microbe

Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells

(2010) Roopali Gandhi et al.   NATURE IMMUNOLOGY

Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

(2010) Tobias Steinfeldt et al.   PLOS BIOLOGY

Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling

(2009) Shaohui Hu et al.   CELL

Protein Acetylation Microarray Reveals that NuA4 Controls Key Metabolic Target Regulating Gluconeogenesis

(2009) Yu-yi Lin et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

Toxoplasma gondii: 25 years and 25 major advances for the field

(2009) John C. Boothroyd   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Protein Array Identification of Substrates of the Epstein-Barr Virus Protein Kinase BGLF4

(2009) J. Zhu et al.   JOURNAL OF VIROLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation

(2008) Julie Brunet et al.   CELLULAR MICROBIOLOGY

The History ofToxoplasma gondii—The First 100 Years

(2008) JITENDER P. DUBEY   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Kiss and spit: the dual roles of Toxoplasma rhoptries

(2007) John C. Boothroyd et al.   NATURE REVIEWS MICROBIOLOGY