ORF3a Protein of Severe Acute Respiratory Syndrome Coronavirus 2 Inhibits Interferon-Activated Janus Kinase/Signal Transducer and Activator of Transcription Signaling via Elevating Suppressor of Cytokine Signaling 1

Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis

(2021) Santhamani Ramasamy et al.   CLINICAL MICROBIOLOGY REVIEWS

SARS-CoV-2 non-structural protein 1 inhibits the interferon response by causing depletion of key host signaling factors.

(2021) Anil Kumar et al.   JOURNAL OF VIROLOGY

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

(2021) Manuel Hayn et al.   Cell Reports

Role of Structural and Non-Structural Proteins and Therapeutic Targets of SARS-CoV-2 for COVID-19

(2021) Rohitash Yadav et al.   Cells

The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes

(2021) Yabin Zhang et al.   Cell Discovery

miR-122 promotes virus-induced lung disease by targeting SOCS1

(2021) Adam M. Collison et al.   JCI Insight

Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein

(2021) Jack Chun-Chieh Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zika Virus-Induction of the Suppressor of Cytokine Signaling 1/3 Contributes to the Modulation of Viral Replication

(2020) Rak-Kyun Seong et al.   Pathogens

The Architecture of SARS-CoV-2 Transcriptome

(2020) Dongwan Kim et al.   CELL

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

Clinical and immunological features of severe and moderate coronavirus disease 2019

(2020) Guang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis

(2020) Changlin Wang et al.   Frontiers in Microbiology

SARS-CoV-2 and ORF3a: Nonsynonymous Mutations, Functional Domains, and Viral Pathogenesis

(2020) Elio Issa et al.   mSystems

The ORF3a protein of SARS-CoV-2 induces apoptosis in cells

(2020) Yujie Ren et al.   Cellular & Molecular Immunology

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Influenza a virus antagonizes type I and type II interferon responses via SOCS1-dependent ubiquitination and degradation of JAK1

(2020) Yinping Du et al.   Virology Journal

Activation and evasion of type I interferon responses by SARS-CoV-2

(2020) Xiaobo Lei et al.   Nature Communications

Innate immunity during SARS‐CoV‐2: evasion strategies and activation trigger hypoxia and vascular damage

(2020) S. Amor et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

(2020) Lisa Miorin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evasion of Type I Interferon by SARS-CoV-2

(2020) Hongjie Xia et al.   Cell Reports

Lower Circulating Interferon-Gamma Is a Risk Factor for Lung Fibrosis in COVID-19 Patients

(2020) Zhong-Jie Hu et al.   Frontiers in Immunology

SOCS, Intrinsic Virulence Factors, and Treatment of COVID-19

(2020) Howard M. Johnson et al.   Frontiers in Immunology

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

Porcine Reproductive and Respiratory Syndrome Virus Enhances Self-Replication via AP-1–Dependent Induction of SOCS1

(2019) Xuegang Luo et al.   JOURNAL OF IMMUNOLOGY

The molecular basis of JAK/STAT inhibition by SOCS1

(2018) Nicholas P. D. Liau et al.   Nature Communications

Coronavirus TGEV Evades the Type I Interferon Response through IRE1α-Mediated Manipulation of the miR-30a-5p/SOCS1/3 Axis

(2018) Yanlong Ma et al.   JOURNAL OF VIROLOGY

Inhibition of murine herpesvirus-68 replication by IFN-gamma in macrophages is counteracted by the induction of SOCS1 expression

(2018) Yong Shen et al.   PLoS Pathogens

Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation

(2016) Liping Yang et al.   JOURNAL OF VIROLOGY

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

(2015) Edmond M. Linossi et al.   IMMUNOLOGICAL REVIEWS

Respiratory Syncytial Virus Nonstructural Proteins Upregulate SOCS1 and SOCS3 in the Different Manner from Endogenous IFN Signaling

(2015) Junwen Zheng et al.   Journal of Immunology Research

A SOCS1/3 Antagonist Peptide Protects Mice Against Lethal Infection with Influenza A Virus

(2015) Chulbul M. Ahmed et al.   Frontiers in Immunology

Cutting Edge: Innate Immune Response Triggered by Influenza A Virus Is Negatively Regulated by SOCS1 and SOCS3 through a RIG-I/IFNAR1-Dependent Pathway

(2014) J. Pothlichet et al.   JOURNAL OF IMMUNOLOGY

Porcine Reproductive and Respiratory Syndrome Virus Nsp1  Inhibits Interferon-Activated JAK/STAT Signal Transduction by Inducing Karyopherin- 1 Degradation

(2013) R. Wang et al.   JOURNAL OF VIROLOGY

Variable interference with interferon signal transduction by different strains of porcine reproductive and respiratory syndrome virus

(2013) Rong Wang et al.   VETERINARY MICROBIOLOGY

The SOCS box-Adapting proteins for ubiquitination and proteasomal degradation

(2012) Edmond M. Linossi et al.   IUBMB LIFE

Enhancement of Antiviral Immunity by Small Molecule Antagonist of Suppressor of Cytokine Signaling

(2010) C. M. I. Ahmed et al.   JOURNAL OF IMMUNOLOGY

Viral Exploitation of Host SOCS Protein Functions

(2010) L. N. Akhtar et al.   JOURNAL OF VIROLOGY

Human Suppressor of Cytokine Signaling 1 Controls Immunostimulatory Activity of Monocyte-Derived Dendritic Cells

(2009) B. Hong et al.   CANCER RESEARCH

HSV-1-Induced SOCS-1 Expression in Keratinocytes: Use of a SOCS-1 Antagonist to Block a Novel Mechanism of Viral Immune Evasion

(2009) K. G. Frey et al.   JOURNAL OF IMMUNOLOGY