Myxoma Virus-Encoded Host Range Protein M029: A Multifunctional Antagonist Targeting Multiple Host Antiviral and Innate Immune Pathways

Oncolytic Virotherapy with Myxoma Virus

(2020) Masmudur M. Rahman et al.   Journal of Clinical Medicine

Parallel adaptation of rabbit populations to myxoma virus

(2019) Joel M. Alves et al.   SCIENCE

The search for a PKR code — Differential regulation of Protein Kinase R activity by diverse RNA and protein regulators

(2019) Charles Bou-Nader et al.   RNA

First outbreak of myxomatosis in Iberian hares ( Lepus granatensis )

(2019) Ignacio García‐Bocanegra et al.   Transboundary and Emerging Diseases

Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (Lepus granatensis)

(2019) Ana Águeda-Pinto et al.   Viruses-Basel

Myxoma virus jumps species to the Iberian hare

(2019) Kevin P. Dalton et al.   Transboundary and Emerging Diseases

Vaccinia Virus Ankyrin-Repeat/F-Box Protein Targets Interferon-Induced IFITs for Proteasomal Degradation

(2019) Ruikang Liu et al.   Cell Reports

Vaccinia-based vaccines to biothreat and emerging viruses

(2018) Les P. Nagata et al.   Biotechnology & Genetic Engineering Reviews

Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review

(2018) Edis Dzananovic et al.   Biotechnology & Genetic Engineering Reviews

Ectromelia virus lacking the E3L ortholog is replication-defective and nonpathogenic but does induce protective immunity in a mouse strain susceptible to lethal mousepox

(2018) Tiffany R. Frey et al.   VIROLOGY

Poxviral protein E3–altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor–stimulated immune responses

(2018) Alan Dempsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A DNA-sensing–independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-κB–mediated innate immunity against DNA virus infection

(2018) Yee Ching Ng et al.   NUCLEIC ACIDS RESEARCH

Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3

(2017) Heather Koehler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Next step in the ongoing arms race between myxoma virus and wild rabbits in Australia is a novel disease phenotype

(2017) Peter J. Kerr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ectromelia virus accumulates less double-stranded RNA compared to vaccinia virus in BS-C-1 cells

(2017) Tiffany R. Frey et al.   VIROLOGY

Myxoma Virus dsRNA Binding Protein M029 Inhibits the Type I IFN‐Induced Antiviral State in a Highly Species‐Specific Fashion

(2017) Masmudur Rahman et al.   Viruses-Basel

Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells

(2017) Masmudur M. Rahman et al.   Scientific Reports

Modified Vaccinia Virus Ankara Preferentially Targets Antigen Presenting Cells In Vitro, Ex Vivo and In Vivo

(2017) Arwen F. Altenburg et al.   Scientific Reports

Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants

(2016) Ruikang Liu et al.   JOURNAL OF VIROLOGY

Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates

(2016) Chen Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monkeypox virus induces the synthesis of less dsRNA than vaccinia virus, and is more resistant to the anti-poxvirus drug, IBT, than vaccinia virus

(2016) William D. Arndt et al.   VIROLOGY

Stress Beyond Translation: Poxviruses and More

(2016) Jason Liem et al.   Viruses-Basel

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

(2016) Alissa M. Pham et al.   PLoS Pathogens

Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus

(2015) William D. Arndt et al.   JOURNAL OF VIROLOGY

Mutational Analysis of Vaccinia Virus E3 Protein: the Biological Functions Do Not Correlate with Its Biochemical Capacity To Bind Double-Stranded RNA

(2015) Kevin J. Dueck et al.   JOURNAL OF VIROLOGY

Myxoma Virus and the Leporipoxviruses: An Evolutionary Paradigm

(2015) Peter Kerr et al.   Viruses-Basel

The Evolution of Poxvirus Vaccines

(2015) Lucas Sánchez-Sampedro et al.   Viruses-Basel

Processing of Double-Stranded RNA in Mammalian Cells: A Direct Antiviral Role?

(2014) Michael P. Gantier   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Enhancing poxvirus vectors vaccine immunogenicity

(2014) Juan García-Arriaza et al.   Human Vaccines & Immunotherapeutics

DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication

(2013) Anthony Fullam et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

ISG15 Is Counteracted by Vaccinia Virus E3 Protein and Controls the Proinflammatory Response against Viral Infection

(2013) B. Eduardo-Correia et al.   JOURNAL OF VIROLOGY

Genome Scale Evolution of Myxoma Virus Reveals Host-Pathogen Adaptation and Rapid Geographic Spread

(2013) Peter J. Kerr et al.   JOURNAL OF VIROLOGY

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Reflections on the early development of poxvirus vectors

(2013) Bernard Moss   VACCINE

Myxoma Virus Protein M029 Is a Dual Function Immunomodulator that Inhibits PKR and Also Conscripts RHA/DHX9 to Promote Expanded Host Tropism and Viral Replication

(2013) Masmudur M. Rahman et al.   PLoS Pathogens

Myxomatosis in Australia and Europe: A model for emerging infectious diseases

(2012) Peter J Kerr   ANTIVIRAL RESEARCH

Innate Immune Response of Human Plasmacytoid Dendritic Cells to Poxvirus Infection Is Subverted by Vaccinia E3 via Its Z-DNA/RNA Binding Domain

(2012) Hua Cao et al.   PLoS One

Myxomavirus as a vector for the immunisation of sheep: Protection study against challenge with bluetongue virus

(2012) Sokunthea Top et al.   VACCINE

Evolutionary History and Attenuation of Myxoma Virus on Two Continents

(2012) Peter J. Kerr et al.   PLoS Pathogens

DHX9 Pairs with IPS-1 To Sense Double-Stranded RNA in Myeloid Dendritic Cells

(2011) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

Myxoma Virus Induces Type I Interferon Production in Murine Plasmacytoid Dendritic Cells via a TLR9/MyD88-, IRF5/IRF7-, and IFNAR-Dependent Pathway

(2011) P. Dai et al.   JOURNAL OF VIROLOGY

Comparative Analysis of Poxvirus Orthologues of the Vaccinia Virus E3 Protein: Modulation of Protein Kinase R Activity, Cytokine Responses, and Virus Pathogenicity

(2011) C. Myskiw et al.   JOURNAL OF VIROLOGY

Host-Range Restriction of Vaccinia Virus E3L Deletion Mutant Can Be Overcome In Vitro, but Not In Vivo, by Expression of the Influenza Virus NS1 Protein

(2011) Susana Guerra et al.   PLoS One

Attenuated NYCBH vaccinia virus deleted for the E3L gene confers partial protection against lethal monkeypox virus disease in cynomolgus macaques

(2011) Karen L. Denzler et al.   VACCINE

The NYCBH vaccinia virus deleted for the innate immune evasion gene, E3L, protects rabbits against lethal challenge by rabbitpox virus

(2011) Karen L. Denzler et al.   VACCINE

Activation of host pattern recognition receptors by viruses

(2010) Kiva Brennan et al.   CURRENT OPINION IN MICROBIOLOGY

Roles of Vaccinia Virus Genes E3L and K3L and Host Genes PKR and RNase L during Intratracheal Infection of C57BL/6 Mice

(2010) A. D. Rice et al.   JOURNAL OF VIROLOGY

The immunoregulatory properties of oncolytic myxoma virus and their implications in therapeutics

(2010) Jia Liu et al.   MICROBES AND INFECTION

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

(2010) T. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Interferon System and Vaccinia Virus Evasion Mechanisms

(2009) Beatriz Perdiguero et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Induction of Alpha/Beta Interferon by Myxoma Virus Is Selectively Abrogated When Primary Mouse Embryo Fibroblasts Become Immortalized

(2009) F. Wang et al.   JOURNAL OF VIROLOGY

Vaccinia Virus E3 Suppresses Expression of Diverse Cytokines through Inhibition of the PKR, NF- B, and IRF3 Pathways

(2009) C. Myskiw et al.   JOURNAL OF VIROLOGY

Safety and immunogenicity of myxoma virus as a new viral vector for small ruminants

(2008) B. Pignolet et al.   JOURNAL OF GENERAL VIROLOGY

Vaccinia Virus Subverts a Mitochondrial Antiviral Signaling Protein-Dependent Innate Immune Response in Keratinocytes through Its Double-Stranded RNA Binding Protein, E3

(2008) L. Deng et al.   JOURNAL OF VIROLOGY

Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Scarification vaccination

(2008) Garilyn M. Jentarra et al.   VACCINE

RIG-I Mediates the Co-Induction of Tumor Necrosis Factor and Type I Interferon Elicited by Myxoma Virus in Primary Human Macrophages

(2008) Fuan Wang et al.   PLoS Pathogens

Vaccinia Virus E3 Protein Prevents the Antiviral Action of ISG15

(2008) Susana Guerra et al.   PLoS Pathogens

Vaccinia viruses with mutations in the E3L gene as potential replication-competent, attenuated vaccines: Intra-nasal vaccination

(2007) Sangeetha Vijaysri et al.   VACCINE