The Ins and Outs of Anthrax Toxin

An outbreak of infection with Bacillus anthracis in injecting drug users in Scotland

(2017) C N Ramsay et al.   Eurosurveillance

Disarmed anthrax toxin delivers antisense oligonucleotides and siRNA with high efficiency and low toxicity

(2015) Paul D.R. Dyer et al.   JOURNAL OF CONTROLLED RELEASE

Atomic structure of anthrax protective antigen pore elucidates toxin translocation

(2015) Jiansen Jiang et al.   NATURE

Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen

(2015) Amy E. Rabideau et al.   Scientific Reports

Lethal Factor, but Not Edema Factor, Is Required to Cause Fatal Anthrax in Cynomolgus Macaques after Pulmonary Spore Challenge

(2014) Julie A. Hutt et al.   AMERICAN JOURNAL OF PATHOLOGY

Monitoring Endocytic Trafficking of Anthrax Lethal Factor by Precise and Quantitative Protein Labeling

(2014) Siqi Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Involvement of Urokinase-Type Plasminogen Activator System in Cancer: An Overview

(2014) Ahmed H. Mekkawy et al.   MEDICINAL RESEARCH REVIEWS

Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities

(2014) Diane E. Peters et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Key tissue targets responsible for anthrax-toxin-induced lethality

(2013) Shihui Liu et al.   NATURE

Calpain-dependent cytoskeletal rearrangement exploited for anthrax toxin endocytosis

(2013) S.-Y. Jeong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hijacking Multivesicular Bodies Enables Long-Term and Exosome-Mediated Long-Distance Action of Anthrax Toxin

(2013) Laurence Abrami et al.   Cell Reports

Capillary morphogenesis protein-2 is required for mouse parturition by maintaining uterine collagen homeostasis

(2012) Diane E. Peters et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TEM8/ANTXR1 Blockade Inhibits Pathological Angiogenesis and Potentiates Tumoricidal Responses against Multiple Cancer Types

(2012) Amit Chaudhary et al.   CANCER CELL

Differential Contribution of Bacillus anthracis Toxins to Pathogenicity in Two Animal Models

(2012) Haim Levy et al.   INFECTION AND IMMUNITY

An overview of anthrax infection including the recently identified form of disease in injection drug users

(2012) Caitlin W. Hicks et al.   INTENSIVE CARE MEDICINE

Anthrax Toxin Receptor 2 Functions in ECM Homeostasis of the Murine Reproductive Tract and Promotes MMP Activity

(2012) Claire V. Reeves et al.   PLoS One

The Receptors that Mediate the Direct Lethality of Anthrax Toxin

(2012) Shihui Liu et al.   Toxins

Noninvasive Imaging Technologies Reveal Edema Toxin as a Key Virulence Factor in Anthrax

(2011) Fabien Dumetz et al.   AMERICAN JOURNAL OF PATHOLOGY

The dark sides of capillary morphogenesis gene 2

(2011) Julie Deuquet et al.   EMBO JOURNAL

Anthrax Edema Toxin Impairs Clearance in Mice

(2011) Inka Sastalla et al.   INFECTION AND IMMUNITY

Glycogen Synthase Kinase 3 Activation Is Important for Anthrax Edema Toxin-Induced Dendritic Cell Maturation and Anthrax Toxin Receptor 2 Expression in Macrophages

(2011) Jason L. Larabee et al.   INFECTION AND IMMUNITY

Domain Flexibility Modulates the Heterogeneous Assembly Mechanism of Anthrax Toxin Protective Antigen

(2011) Geoffrey K. Feld et al.   JOURNAL OF MOLECULAR BIOLOGY

New insights into the biological effects of anthrax toxins: linking cellular to organismal responses

(2011) Annabel Guichard et al.   MICROBES AND INFECTION

Crystal structure of the Vibrio cholerae cytolysin heptamer reveals common features among disparate pore-forming toxins

(2011) S. De et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax Toxin Targeting of Myeloid Cells through the CMG2 Receptor Is Essential for Establishment of Bacillus anthracis Infections in Mice

(2010) Shihui Liu et al.   Cell Host & Microbe

Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting

(2010) Chrisostomi Gialeli et al.   FEBS Journal

Role of the Protective Antigen Octamer in the Molecular Mechanism of Anthrax Lethal Toxin Stabilization in Plasma

(2010) Alexander F. Kintzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Anthrax infection in drug users

(2010) Malcolm G Booth et al.   LANCET

Structural basis for the unfolding of anthrax lethal factor by protective antigen oligomers

(2010) Geoffrey K Feld et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Heterodimeric integrin complexes containing  1-integrin promote internalization and lethality of anthrax toxin

(2010) M. Martchenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake

(2010) L. Abrami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammasome Sensor Nlrp1b-Dependent Resistance to Anthrax Is Mediated by Caspase-1, IL-1 Signaling and Neutrophil Recruitment

(2010) Mahtab Moayeri et al.   PLoS Pathogens

Endocytosis of the Anthrax Toxin Is Mediated by Clathrin, Actin and Unconventional Adaptors

(2010) Laurence Abrami et al.   PLoS Pathogens

Emergence of Anthrax Edema Toxin as a Master Manipulator of Macrophage and B Cell Functions

(2010) Bryan T. Gnade et al.   Toxins

A review of cutaneous anthrax and its outcome

(2010) Mehmet Doganay et al.   Journal of Infection and Public Health

Host-Derived Tumor Endothelial Marker 8 Promotes the Growth of Melanoma

(2009) M. Cullen et al.   CANCER RESEARCH

Bacillus anthracis Edema Toxin Impairs Neutrophil Actin-Based Motility

(2009) S. E. Szarowicz et al.   INFECTION AND IMMUNITY

Cutting Edge: Resistance to Bacillus anthracis Infection Mediated by a Lethal Toxin Sensitive Allele of Nalp1b/Nlrp1b

(2009) Jill K. Terra et al.   JOURNAL OF IMMUNOLOGY

The Protective Antigen Component of Anthrax Toxin Forms Functional Octameric Complexes

(2009) Alexander F. Kintzer et al.   JOURNAL OF MOLECULAR BIOLOGY

Capillary morphogenesis protein-2 is the major receptor mediating lethality of anthrax toxin in vivo

(2009) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maturation modulates caspase-1-independent responses of dendritic cells to Anthrax Lethal Toxin

(2008) Núria Reig et al.   CELLULAR MICROBIOLOGY

Functional interactions between anthrax toxin receptors and the WNT signalling protein LRP6

(2008) Laurence Abrami et al.   CELLULAR MICROBIOLOGY

Role of Anthrax Toxins in Dissemination, Disease Progression, and Induction of Protective Adaptive Immunity in the Mouse Aerosol Challenge Model

(2008) C. L. Loving et al.   INFECTION AND IMMUNITY

Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus

(2008) C. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA