Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
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Title
Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon
Authors
Keywords
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Journal
Nature Communications
Volume 14, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-06-14
DOI
10.1038/s41467-023-39174-1
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Note: Only part of the references are listed.- Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
- (2022) Chansavath Phetsouphanh et al. NATURE IMMUNOLOGY
- Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection
- (2022) Aaqib Sohail et al. PLoS Pathogens
- Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response
- (2022) Dylan G. Ryan et al. iScience
- A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications
- (2022) Douglas B. Kell et al. BIOCHEMICAL JOURNAL
- Immunothrombosis and the molecular control of tissue factor by pyroptosis: prospects for new anticoagulants
- (2022) Tristram A. J. Ryan et al. BIOCHEMICAL JOURNAL
- Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages
- (2022) Marah C. Runtsch et al. Cell Metabolism
- Itaconate inhibits TET DNA dioxygenases to dampen inflammatory responses
- (2022) Lei-Lei Chen et al. NATURE CELL BIOLOGY
- ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data
- (2022) Zhaonan Zou et al. NUCLEIC ACIDS RESEARCH
- Caspase-4/11 exacerbates disease severity in SARS–CoV-2 infection by promoting inflammation and immunothrombosis
- (2022) Mostafa M. Eltobgy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry
- (2022) Edward R Kastenhuber et al. eLife
- von Willebrand factor links primary hemostasis to innate immunity
- (2022) Clive Drakeford et al. Nature Communications
- Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19
- (2022) Allison K. Maher et al. Nature Communications
- Defective activation and regulation of type I interferon immunity is associated with increasing COVID-19 severity
- (2022) Nikaïa Smith et al. Nature Communications
- Recent advances in the research and management of sepsis-associated DIC
- (2021) Toshiaki Iba et al. INTERNATIONAL JOURNAL OF HEMATOLOGY
- Heparin prevents caspase-11-dependent septic lethality independent of anticoagulant properties
- (2021) Yiting Tang et al. IMMUNITY
- Dimethyl fumarate induces ferroptosis and impairs NF-κB/STAT3 signaling in DLBCL
- (2021) Anja Schmitt et al. BLOOD
- The spatial landscape of lung pathology during COVID-19 progression
- (2021) André F. Rendeiro et al. NATURE
- Interplay between inflammation and thrombosis in cardiovascular pathology
- (2021) Konstantin Stark et al. Nature Reviews Cardiology
- Circulating extracellular vesicles are endowed with enhanced procoagulant activity in SARS-CoV-2 infection
- (2021) Carolina Balbi et al. EBioMedicine
- The interferon landscape along the respiratory tract impacts the severity of COVID-19
- (2021) Benedetta Sposito et al. CELL
- Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19
- (2021) NEW ENGLAND JOURNAL OF MEDICINE
- Inflammasome activation promotes venous thrombosis through pyroptosis
- (2021) Yan Zhang et al. Blood Advances
- Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study
- (2020) Kristina E Rudd et al. LANCET
- Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19
- (2020) Maximilian Ackermann et al. NEW ENGLAND JOURNAL OF MEDICINE
- Neutrophil Extracellular Traps (NETs) Contribute to Immunothrombosis in COVID-19 Acute Respiratory Distress Syndrome
- (2020) Elizabeth A Middleton et al. BLOOD
- The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
- (2020) Alexander Hooftman et al. Cell Metabolism
- Immunothrombotic Dysregulation in COVID-19 Pneumonia is Associated with Respiratory Failure and Coagulopathy
- (2020) Leo Nicolai et al. CIRCULATION
- Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients
- (2020) Jérôme Hadjadj et al. SCIENCE
- Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19
- (2020) Eugenio D. Hottz et al. BLOOD
- Complement and tissue factor–enriched neutrophil extracellular traps are key drivers in COVID-19 immunothrombosis
- (2020) Panagiotis Skendros et al. JOURNAL OF CLINICAL INVESTIGATION
- Colchicine in Patients with Chronic Coronary Disease
- (2020) Stefan M. Nidorf et al. NEW ENGLAND JOURNAL OF MEDICINE
- Succination inactivates gasdermin D and blocks pyroptosis
- (2020) Fiachra Humphries et al. SCIENCE
- SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
- (2020) David Olagnier et al. Nature Communications
- Patients With COVID-19 Have Elevated Levels of Circulating Extracellular Vesicle Tissue Factor Activity That Is Associated With Severity and Mortality
- (2020) Axel Rosell et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Von Willebrand factor propeptide in severe coronavirus disease 2019 (COVID‐19): evidence of acute and sustained endothelial cell activation
- (2020) Soracha E. Ward et al. BRITISH JOURNAL OF HAEMATOLOGY
- Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients
- (2020) Tamara S. Rodrigues et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Thromboinflammation: Challenges of Therapeutically Targeting Coagulation and other Host Defence Mechanisms
- (2019) Shaun P. Jackson et al. BLOOD
- Dimethyl Fumarate Disrupts Human Innate Immune Signaling by Targeting the IRAK4–MyD88 Complex
- (2019) Balyn W. Zaro et al. JOURNAL OF IMMUNOLOGY
- The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin
- (2019) Laura C. Burzynski et al. IMMUNITY
- Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis
- (2019) Congqing Wu et al. IMMUNITY
- Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction
- (2019) Jean-Claude Tardif et al. NEW ENGLAND JOURNAL OF MEDICINE
- 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
- (2019) Shan-Ting Liao et al. Nature Communications
- Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure
- (2019) Xinyu Yang et al. IMMUNITY
- Tissue Factor
- (2018) Steven P. Grover et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Staphylococcus aureus- induced complement activation promotes tissue factor-mediated coagulation
- (2018) E. W. Skjeflo et al. JOURNAL OF THROMBOSIS AND HAEMOSTASIS
- Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
- (2018) Michael D. Kornberg et al. SCIENCE
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- Low-Dose Methotrexate for the Prevention of Atherosclerotic Events
- (2018) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Caspase-11–mediated endothelial pyroptosis underlies endotoxemia-induced lung injury
- (2017) Kwong Tai Cheng et al. JOURNAL OF CLINICAL INVESTIGATION
- Recognizing Sepsis as a Global Health Priority — A WHO Resolution
- (2017) Konrad Reinhart et al. NEW ENGLAND JOURNAL OF MEDICINE
- Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- (2017) Paul M Ridker et al. NEW ENGLAND JOURNAL OF MEDICINE
- Assessment of Clinical Criteria for Sepsis
- (2016) Christopher W. Seymour et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Inflammation and thrombosis – testing the hypothesis with anti- inflammatory drug trials
- (2016) Emilia D’Ugo et al. THROMBOSIS AND HAEMOSTASIS
- Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
- (2015) Nobuhiko Kayagaki et al. NATURE
- Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
- (2015) Jianjin Shi et al. NATURE
- Multiple roles of the coagulation protease cascade during virus infection
- (2014) S. Antoniak et al. BLOOD
- Inflammatory caspases are innate immune receptors for intracellular LPS
- (2014) Jianjin Shi et al. NATURE
- PAR-1 contributes to the innate immune response during viral infection
- (2013) Silvio Antoniak et al. JOURNAL OF CLINICAL INVESTIGATION
- The Pathogenesis of the Antiphospholipid Syndrome
- (2013) Bill Giannakopoulos et al. NEW ENGLAND JOURNAL OF MEDICINE
- Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock
- (2013) J. A. Hagar et al. SCIENCE
- Type I interferons modulate vascular function, repair, thrombosis, and plaque progression in murine models of lupus and atherosclerosis
- (2012) Seth G. Thacker et al. ARTHRITIS AND RHEUMATISM
- TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria
- (2012) Vijay A.K. Rathinam et al. CELL
- Evidence-Based Management of Anticoagulant Therapy
- (2012) Anne Holbrook et al. CHEST
- INTERFEROME v2.0: an updated database of annotated interferon-regulated genes
- (2012) Irina Rusinova et al. NUCLEIC ACIDS RESEARCH
- Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
- (2011) Ralf A. Linker et al. BRAIN
- Anti-phospholipid antibodies contribute to arteriosclerosis in patients with systemic lupus erythematosus through induction of tissue factor expression and cytokine production from peripheral blood mononuclear cells
- (2011) Yukari Motoki et al. THROMBOSIS RESEARCH
- The Role of Tissue Factor and Factor VIIa in Hemostasis
- (2009) Nigel Mackman ANESTHESIA AND ANALGESIA
- Coagulation and innate immune responses: can we view them separately?
- (2009) M. Delvaeye et al. BLOOD
- The Immunological Genome Project: networks of gene expression in immune cells
- (2008) Tracy S P Heng et al. NATURE IMMUNOLOGY
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