Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

(2021) Peter A. Szabo et al.   IMMUNITY

Parallels in Sepsis and COVID-19 Conditions: Implications for Managing Severe COVID-19

(2021) Charles Ochieng’ Olwal et al.   Frontiers in Immunology

Critical Determinants of Cytokine Storm and Type I Interferon Response in COVID-19 Pathogenesis

(2021) Santhamani Ramasamy et al.   CLINICAL MICROBIOLOGY REVIEWS

Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity

(2021) Melissa Saichi et al.   NATURE CELL BIOLOGY

Interplay between inflammation and thrombosis in cardiovascular pathology

(2021) Konstantin Stark et al.   Nature Reviews Cardiology

Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for hospitalised patients with mild or moderate COVID-19 pneumonia: a structured summary of a study protocol for a randomised controlled trial

(2021) Nikhil Vergis et al.   Trials

Virus Caused Imbalance of Type I IFN Responses and Inflammation in COVID-19

(2021) Jintao Zhang et al.   Frontiers in Immunology

The single-cell epigenomic and transcriptional landscape of immunity to influenza vaccination

(2021) Florian Wimmers et al.   CELL

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

(2021) Rishi K Gupta et al.   Lancet Microbe

Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia

(2020) Ning Tang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Host-Viral Infection Maps Reveal Signatures of Severe COVID-19 Patients

(2020) Pierre Bost et al.   CELL

Complex Immune Dysregulation in COVID-19 Patients with Severe Respiratory Failure

(2020) Evangelos J. Giamarellos-Bourboulis et al.   Cell Host & Microbe

Incidence of venous thromboembolism in hospitalized patients with COVID‐19

(2020) Saskia Middeldorp et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19

(2020) Mingfeng Liao et al.   NATURE MEDICINE

Reduced monocytic HLA-DR expression indicates immunosuppression in critically ill COVID-19 patients

(2020) Thibaud Spinetti et al.   ANESTHESIA AND ANALGESIA

COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection

(2020) Hanny Al-Samkari et al.   BLOOD

Severe COVID-19 is marked by a dysregulated myeloid cell compartment

(2020) Jonas Schulte-Schrepping et al.   CELL

Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19

(2020) Aymeric Silvin et al.   CELL

Acute SARS-CoV-2 Infection Impairs Dendritic Cell and T Cell Responses

(2020) Runhong Zhou et al.   IMMUNITY

Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis

(2020) Leiwen Fu et al.   JOURNAL OF INFECTION

Longitudinal analyses reveal immunological misfiring in severe COVID-19

(2020) Carolina Lucas et al.   NATURE

A single-cell atlas of the peripheral immune response in patients with severe COVID-19

(2020) Aaron J. Wilk et al.   NATURE MEDICINE

Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

(2020) Jérôme Hadjadj et al.   SCIENCE

Early thromboembolic events in hospitalized COVID-19 patients

(2020) Raphael J. Rosen   THROMBOSIS RESEARCH

Incidence of thrombotic complications in critically ill ICU patients with COVID-19

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Severe immunosuppression and not a cytokine storm characterize COVID-19 infections

(2020) Kenneth E. Remy et al.   JCI Insight

Prevalence and Outcomes of D-Dimer Elevation in Hospitalized Patients With COVID-19

(2020) Jeffrey S. Berger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet activation and platelet-monocyte aggregate formation trigger tissue factor expression in patients with severe COVID-19

(2020) Eugenio D. Hottz et al.   BLOOD

Contribution of monocytes and macrophages to the local tissue inflammation and cytokine storm in COVID-19: Lessons from SARS and MERS, and potential therapeutic interventions

(2020) Abdollah Jafarzadeh et al.   LIFE SCIENCES

Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

(2020) Prabhu S. Arunachalam et al.   SCIENCE

A Longitudinal Study of Immune Cells in Severe COVID-19 Patients

(2020) Didier Payen et al.   Frontiers in Immunology

SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution

(2020) Rafael J. Argüello et al.   Cell Metabolism

Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases

(2019) Theodore S. Kapellos et al.   Frontiers in Immunology

Activation and suppression of haematopoietic integrins in hemostasis and immunity

(2019) Martijn A. Nolte et al.   BLOOD

TLR7 and TLR8 activate distinct pathways in monocytes during RNA virus infection

(2019) Marine de Marcken et al.   Science Signaling

Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

(2017) Madhav Kishore et al.   IMMUNITY

A Test in Context: D-Dimer

(2017) Jeffrey I. Weitz et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis

(2017) Jorge Domínguez-Andrés et al.   PLoS Pathogens

Cross Talk Pathways Between Coagulation and Inflammation

(2016) Jonathan H. Foley et al.   CIRCULATION RESEARCH

XGR software for enhanced interpretation of genomic summary data, illustrated by application to immunological traits

(2016) Hai Fang et al.   Genome Medicine

Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study

(2016) Emma E Davenport et al.   Lancet Respiratory Medicine

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Platelet-Monocyte Aggregates and C-Reactive Protein are Associated with VTE in Older Surgical Patients

(2016) Lauren Shih et al.   Scientific Reports

Platelet transactivation by monocytes promotes thrombosis in heparin-induced thrombocytopenia

(2015) V. Tutwiler et al.   BLOOD

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis

(2015) Jacob H. Levine et al.   CELL

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α

(2015) Irina N. Shalova et al.   IMMUNITY

Beyond receptors and signaling: epigenetic factors in the regulation of innate immunity

(2015) Stuti Mehta et al.   IMMUNOLOGY AND CELL BIOLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells

(2015) Takumi Shiraishi et al.   Oncotarget

Transcription and enhancer profiling in human monocyte subsets

(2014) C. Schmidl et al.   BLOOD

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

New Fundamentals in Hemostasis

(2013) Henri H. Versteeg et al.   PHYSIOLOGICAL REVIEWS

RNA-SeQC: RNA-seq metrics for quality control and process optimization

(2012) David S. DeLuca et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Endotoxin Tolerance Represents a Distinctive State of Alternative Polarization (M2) in Human Mononuclear Cells

(2011) O. M. Pena et al.   JOURNAL OF IMMUNOLOGY

Tim-3 regulates pro- and anti-inflammatory cytokine expression in human CD14+ monocytes

(2011) Ying Zhang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

(2011) Margarita Dominguez-Villar et al.   NATURE MEDICINE

Potent Phagocytic Activity with Impaired Antigen Presentation Identifying Lipopolysaccharide-Tolerant Human Monocytes: Demonstration in Isolated Monocytes from Cystic Fibrosis Patients

(2009) Carlos del Fresno et al.   JOURNAL OF IMMUNOLOGY

The role of monocytes in thrombotic disorders

(2009) Gregory Lip et al.   THROMBOSIS AND HAEMOSTASIS

Monocyte-Mediated Defense Against Microbial Pathogens

(2008) Natalya V. Serbina et al.   Annual Review of Immunology