Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry

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Furin cleavage of SARS-CoV-2 Spike promotes but is not essential for infection and cell-cell fusion

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Introduction of Two Prolines and Removal of the Polybasic Cleavage Site Lead to Higher Efficacy of a Recombinant Spike-Based SARS-CoV-2 Vaccine in the Mouse Model

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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity

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SARS-CoV-2 Infection Induces Beta Cell Transdifferentiation

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Targeting SARS-CoV-2-Platelet Interactions in COVID-19 and Vaccine-Related Thrombosis

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Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19

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Phylogenetic Analysis and Structural Modeling of SARS-CoV-2 Spike Protein Reveals an Evolutionary Distinct and Proteolytically Sensitive Activation Loop

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SARS2-CoV-2 and Stroke in a New York Healthcare System

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Clinical Characteristics and Outcomes of COVID-19 Patients With a History of Stroke in Wuhan, China

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SPINT2 inhibits proteases involved in activation of both influenza viruses and metapneumoviruses

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Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes

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Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

(2020) Fabian Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Emerging evidence of a COVID-19 thrombotic syndrome has treatment implications

(2020) Joan T. Merrill et al.   Nature Reviews Rheumatology

SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

(2020) Antoni G. Wrobel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Direct Oral Anticoagulant Use: A Practical Guide to Common Clinical Challenges

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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

(2020) Dorothea Bestle et al.   Life Science Alliance

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(2020) Donald J. Benton et al.   NATURE

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

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Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

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TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection

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A Fluorogenic Peptide Cleavage Assay to Screen for Proteolytic Activity: Applications for coronavirus spike protein activation

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A phase 1/2 trial to evaluate the pharmacokinetics, safety, and efficacy of NI-03 in patients with chronic pancreatitis: study protocol for a randomized controlled trial on the assessment of camostat treatment in chronic pancreatitis (TACTIC)

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Trypsin Treatment Unlocks Barrier for Zoonotic Bat Coronavirus Infection

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Activities of Thrombin and Factor Xa Are Essential for Replication of Hepatitis E Virus and Are Possibly Implicated in ORF1 Polyprotein Processing

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Discovery of Selective Matriptase and Hepsin Serine Protease Inhibitors: Useful Chemical Tools for Cancer Cell Biology

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A peptide-based approach to evaluate the adaptability of influenza A virus to humans based on its hemagglutinin proteolytic cleavage site

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Comparison of Nafamostat Mesilate and Unfractionated Heparin as Anticoagulants during Continuous Renal Replacement Therapy

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A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

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Desmolaris, a novel factor XIa anticoagulant from the salivary gland of the vampire bat (Desmodus rotundus) inhibits inflammation and thrombosis in vivo

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Generation of Multipotent Lung and Airway Progenitors from Mouse ESCs and Patient-Specific Cystic Fibrosis iPSCs

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Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response

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Prothrombin activation on the activated platelet surface optimizes expression of procoagulant activity

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Elastase-mediated Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein at Discrete Sites within the S2 Domain

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Acute physiopathological effects of honeybee (Apis mellifera) envenoming by subcutaneous route in a mouse model

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Pharmacology, Pharmacokinetics, and Pharmacodynamics of Dabigatran Etexilate, an Oral Direct Thrombin Inhibitor

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Characterization of a Highly Conserved Domain within the Severe Acute Respiratory Syndrome Coronavirus Spike Protein S2 Domain with Characteristics of a Viral Fusion Peptide

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Cleavage of the SARS Coronavirus Spike Glycoprotein by Airway Proteases Enhances Virus Entry into Human Bronchial Epithelial Cells In Vitro

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