A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection

(2022) Chansavath Phetsouphanh et al.   NATURE IMMUNOLOGY

Skeletal muscle alterations in patients with acute Covid‐19 and post‐acute sequelae of Covid‐19

(2022) Madu N. Soares et al.   Journal of Cachexia Sarcopenia and Muscle

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection

(2022) Bruce K. Patterson et al.   Frontiers in Immunology

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

(2021) Chaolin Huang et al.   LANCET

COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms

(2021) Joan Loo et al.   THORAX

Viral Involvement in Alzheimer’s Disease

(2021) Ahmad Sait et al.   ACS Chemical Neuroscience

Prolonged elevation of D‐dimer levels in convalescent COVID‐19 patients is independent of the acute phase response

(2021) Liam Townsend et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Sequelae in Adults at 6 Months After COVID-19 Infection

(2021) Jennifer K. Logue et al.   JAMA Network Open

Long-COVID postural tachycardia syndrome: an American Autonomic Society statement

(2021) Satish R. Raj et al.   CLINICAL AUTONOMIC RESEARCH

Post-Ebola syndrome presents with multiple overlapping symptom clusters: evidence from an ongoing cohort study in Eastern Sierra Leone

(2021) Nell G Bond et al.   CLINICAL INFECTIOUS DISEASES

Myopathic changes in patients with long-term fatigue after COVID-19

(2021) J. Agergaard et al.   CLINICAL NEUROPHYSIOLOGY

Ground-glass opacity (GGO): a review of the differential diagnosis in the era of COVID-19

(2021) Diletta Cozzi et al.   JAPANESE JOURNAL OF RADIOLOGY

Humility and Acceptance: Working Within Our Limits With Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

(2021) Simon Décary et al.   JOURNAL OF ORTHOPAEDIC & SPORTS PHYSICAL THERAPY

Post-acute COVID-19 syndrome

(2021) Ani Nalbandian et al.   NATURE MEDICINE

Differences in coagulopathy indices in patients with severe versus non-severe COVID-19: a meta-analysis of 35 studies and 6427 patients

(2021) Alberto Polimeni et al.   Scientific Reports

COVID-19-associated coagulopathy and antithrombotic agents—lessons after 1 year

(2021) Jenneke Leentjens et al.   Lancet Haematology

SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19

(2021) Lize M. Grobbelaar et al.   BIOSCIENCE REPORTS

Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin

(2021) Etheresia Pretorius et al.   Cardiovascular Diabetology

Pulmonary Thrombosis and Thromboembolism in COVID-19

(2021) Hooman D. Poor   CHEST

COVID‐19 and coagulopathy

(2021) Malay Sarkar et al.   Clinical Respiratory Journal

Presence of a SARS-CoV-2 Protein Enhances Amyloid Formation of Serum Amyloid A

(2021) Asis K. Jana et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Kidney Outcomes in Long COVID

(2021) Benjamin Bowe et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Platelets Contribute to Disease Severity in COVID‐19

(2021) Tessa J. Barrett et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Persistent endotheliopathy in the pathogenesis of long COVID syndrome

(2021) Helen Fogarty et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Therapeutic versus prophylactic anticoagulation for patients admitted to hospital with COVID-19 and elevated D-dimer concentration (ACTION): an open-label, multicentre, randomised, controlled trial

(2021) Renato D Lopes et al.   LANCET

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study

(2021) Ioannis Katsoularis et al.   LANCET

The four most urgent questions about long COVID

(2021) Michael Marshall   NATURE

Long COVID and kidney disease

(2021) Sachin Yende et al.   Nature Reviews Nephrology

Therapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19

(2021)   NEW ENGLAND JOURNAL OF MEDICINE

Residual ground glass opacities three months after Covid-19 pneumonia correlate to alteration of respiratory function: The post Covid M3 study

(2021) Justine Frija-Masson et al.   RESPIRATORY MEDICINE

The road to addressing Long Covid

(2021) Nisreen A. Alwan   SCIENCE

Long COVID in children and adolescents

(2021) Ali A. Asadi-Pooya et al.   World Journal of Pediatrics

Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent Symptoms

(2021) Amy D. Proal et al.   Frontiers in Microbiology

Platelets amplify endotheliopathy in COVID-19

(2021) Tessa J. Barrett et al.   Science Advances

Role of Iron Chelation and Protease Inhibition of Natural Products on COVID-19 Infection

(2021) Giuseppe Carota et al.   Journal of Clinical Medicine

The Role of Acidosis in the Pathogenesis of Severe Forms of COVID-19

(2021) Yury D. Nechipurenko et al.   Biology-Basel

Hyperbaric oxygen therapy for the treatment of long COVID: early evaluation of a highly promising intervention

(2021) Tim Robbins et al.   CLINICAL MEDICINE

Clinical Value of COVID-19 Chest Radiography and High-Resolution CT Examination

(2021) Dan Wang et al.   Current Medical Imaging Reviews

Molecular foundations of prion strain diversity

(2021) Manfredi Carta et al.   CURRENT OPINION IN NEUROBIOLOGY

Coagulopathy and COVID-19

(2021) Ferdinando Luca Lorini et al.   EUROPEAN HEART JOURNAL SUPPLEMENTS

Long COVID: long-term effects?

(2021) Alessandro Di Toro et al.   EUROPEAN HEART JOURNAL SUPPLEMENTS

Myocardial Infarction During the COVID-19 Pandemic

(2021) Alexander C. Fanaroff et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The binding of heparin to spike glycoprotein inhibits SARS-CoV-2 infection by three mechanisms

(2021) Giulia Paiardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Untargeted metabolomics of COVID-19 patient serum reveals potential prognostic markers of both severity and outcome

(2021) Ivayla Roberts et al.   Metabolomics

Promotion of non-evidence-based therapeutics within patient-led Long COVID support groups

(2021) Vicky van der Togt et al.   NATURE MEDICINE

Ground-glass opacity on emergency department chest X-ray: a risk factor for in-hospital mortality and organ failure in elderly admitted for COVID-19

(2021) Noel Roig-Marín et al.   POSTGRADUATE MEDICINE

Startling new variant raises urgent questions

(2021) Kai Kupferschmidt   SCIENCE

Incidence of venous thromboembolic events in COVID-19 patients after hospital discharge: A systematic review and meta-analysis

(2021) Marco Zuin et al.   THROMBOSIS RESEARCH

Risk of symptomatic venous thromboembolism in mild and moderate COVID-19: A comparison of two prospective European cohorts

(2021) Delphine Douillet et al.   THROMBOSIS RESEARCH

Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19

(2021) Masako Nishikawa et al.   Nature Communications

Clinical value of laboratory indicators for predicting disease progression and death in patients with COVID-19: a retrospective cohort study

(2021) Qian Wang et al.   BMJ Open

How to recognize and manage COVID-19-associated coagulopathy

(2021) Gloria F. Gerber et al.   Hematology-American Society of Hematology Education Program

Therapeutic potential of induced iron depletion using iron chelators in Covid-19

(2021) Punnoth Poonkuzhi Naseef et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Prevention and management of thrombosis in hospitalised patients with COVID-19 pneumonia

(2021) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

Characterizing Long COVID: Deep Phenotype of a Complex Condition

(2021) Rachel R Deer et al.   EBioMedicine

Long COVID in children

(2021) Deepti Gurdasani et al.   Lancet Child & Adolescent Health

Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19

(2021) Malgorzata Wygrecka et al.   Blood Advances

Relation Between Chest CT Findings and Clinical Conditions of Coronavirus Disease (COVID-19) Pneumonia: A Multicenter Study

(2020) Wei Zhao et al.   AMERICAN JOURNAL OF ROENTGENOLOGY

Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination

(2020) Dan Li et al.   BIOCHEMISTRY

COVID19 coagulopathy in Caucasian patients

(2020) Helen Fogarty et al.   BRITISH JOURNAL OF HAEMATOLOGY

Reporting of D-dimer data in COVID-19: some confusion and potential for misinformation

(2020) Emmanuel J. Favaloro et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): A case series

(2020) Janice Wang et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

ISTH interim guidance on recognition and management of coagulopathy in COVID‐19

(2020) Jecko Thachil et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Coronavirus blood-clot mystery intensifies

(2020) Cassandra Willyard   NATURE

A Champion of Host Defense: A Generic Large-Scale Cause for Platelet Dysfunction and Depletion in Infection

(2020) Martin J. Page et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

MICROVASCULAR THROMBOSIS: EXPERIMENTAL AND CLINICAL IMPLICATIONS

(2020) Monica A. Bray et al.   Translational Research

The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria

(2020) Douglas B. Kell et al.   Frontiers in Immunology

Elevated D-Dimer Levels are Associated with Increased Risk of Mortality in COVID-19

(2020) Siddharth Shah et al.   Cardiology in Review

Can iron chelation as an adjunct treatment of COVID-19 improve the clinical outcome?

(2020) Anis Abobaker   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy

(2020) Carlo Perricone et al.   IMMUNOLOGIC RESEARCH

Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?

(2020) Marvin Edeas et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes

(2020) Corlia Grobler et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Lactoferrin as Protective Natural Barrier of Respiratory and Intestinal Mucosa against Coronavirus Infection and Inflammation

(2020) Elena Campione et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Coagulopathy in COVID‐19

(2020) Toshiaki Iba et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Commentary: Could iron chelators prove to be useful as an adjunct to COVID-19 Treatment Regimens?

(2020) Maria Dalamaga et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Enhanced platelet inhibition treatment improves hypoxemia in patients with severe Covid-19 and hypercoagulability. A case control, proof of concept study

(2020) Maurizio Viecca et al.   PHARMACOLOGICAL RESEARCH

Vascular inflammation and endothelial injury in SARS-CoV-2 infection: The overlooked regulatory cascades implicated by the ACE2 gene cluster

(2020) Claire L Shovlin et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Review of the Chest CT Differential Diagnosis of Ground-Glass Opacities in the COVID Era

(2020) Maansi Parekh et al.   RADIOLOGY

Coronavirus Disease 2019 Coagulopathy: Disseminated Intravascular Coagulation and Thrombotic Microangiopathy—Either, Neither, or Both

(2020) Marcel Levi et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis

(2020) F.A. Klok et al.   THROMBOSIS RESEARCH

Management of post-acute covid-19 in primary care

(2020) Trisha Greenhalgh et al.   BMJ-British Medical Journal

Fluorescence Phenomena in Amyloid and Amyloidogenic Bionanostructures

(2020) B. Apter et al.   Crystals

Endotheliopathy in COVID-19-associated coagulopathy: evidence from a single-centre, cross-sectional study

(2020) George Goshua et al.   Lancet Haematology

Coagulation abnormalities and thrombosis in patients with COVID-19

(2020) Marcel Levi et al.   Lancet Haematology

COVID-19-Related Coagulopathy—Is Transferrin a Missing Link?

(2020) Katie-May McLaughlin et al.   Diagnostics

D-Dimer Concentrations and COVID-19 Severity: A Systematic Review and Meta-Analysis

(2020) Panagiotis Paliogiannis et al.   Frontiers in Public Health

Hyperferritinemia in patients with COVID‐19: An opportunity for iron chelation?

(2020) Vassilios D. Vlahakos et al.   ARTIFICIAL ORGANS

Development and implementation of a COVID-19 near real-time traffic light system in an acute hospital setting

(2020) Marcela P Vizcaychipi et al.   EMERGENCY MEDICINE JOURNAL

COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism/Prophylactic and Therapeutic Management

(2020) Antonis S. Manolis et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

SARS-CoV-2 binds platelet ACE2 to enhance thrombosis in COVID-19

(2020) Si Zhang et al.   Journal of Hematology & Oncology

The Impact of COVID-19 Disease on Platelets and Coagulation

(2020) Geoffrey D. Wool et al.   PATHOBIOLOGY

D-dimer level in COVID-19 infection: a systematic review

(2020) Mehrdad Rostami et al.   Expert Review of Hematology

Lactate Kinetics Reflect Organ Dysfunction and Are Associated with Adverse Outcomes in Intensive Care Unit Patients with COVID-19 Pneumonia: Preliminary Results from a GREEK Single-Centre Study

(2020) Alice G. Vassiliou et al.   Metabolites

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations

(2020) Julia A. Tree et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prevalence of readily detected amyloid blood clots in ‘unclotted’ Type 2 Diabetes Mellitus and COVID-19 plasma: a preliminary report

(2020) Etheresia Pretorius et al.   Cardiovascular Diabetology

Management of COVID‐19‐associated coagulopathy in persons with haemophilia

(2020) Steven W. Pipe et al.   HAEMOPHILIA

Effect of Amyloid-β Monomers on Lipid Membrane Mechanical Parameters–Potential Implications for Mechanically Driven Neurodegeneration in Alzheimer’s Disease

(2020) Dominik Drabik et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heparin Inhibits Cellular Invasion by SARS-CoV-2: Structural Dependence of the Interaction of the Spike S1 Receptor-Binding Domain with Heparin

(2020) Courtney J. Mycroft-West et al.   THROMBOSIS AND HAEMOSTASIS

Coronavirus Disease 2019–Associated Thrombosis and Coagulopathy: Review of the Pathophysiological Characteristics and Implications for Antithrombotic Management

(2020) Luis Ortega‐Paz et al.   Journal of the American Heart Association

Detection of Citrullinated Fibrin in Plasma Clots of Rheumatoid Arthritis Patients and Its Relation to Altered Structural Clot Properties, Disease-Related Inflammation and Prothrombotic Tendency

(2020) Johannes A. Bezuidenhout et al.   Frontiers in Immunology

Akt-Fas to Quell Aberrant T Cell Differentiation and Apoptosis in Covid-19

(2020) Anthony J. Leonardi et al.   Frontiers in Immunology

Thrombosis and Coagulopathy in COVID-19

(2020) Juan Esteban Gómez-Mesa et al.   CURRENT PROBLEMS IN CARDIOLOGY

Serum amyloid A binds to fibrin(ogen), promoting fibrin amyloid formation

(2019) Martin J. Page et al.   Scientific Reports

The Uncertainty Surrounding the Burden of Post-acute Consequences of Dengue Infection

(2019) Trinh Manh Hung et al.   TRENDS IN PARASITOLOGY

Cryo-EM of amyloid fibrils and cellular aggregates

(2019) Anthony WP Fitzpatrick et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Transition of the prion protein from a structured cellular form (PrP C ) to the infectious scrapie agent (PrP Sc )

(2019) Pravas K. Baral et al.   PROTEIN SCIENCE

A Possible Role of Amyloidogenic Blood Clotting in the Evolving Haemodynamics of Female Migraine-With-Aura: Results From a Pilot Study

(2019) Sulette de Villiers et al.   Frontiers in Neurology

Thrombectomy and Thrombolysis of Isolated Posterior Cerebral Artery Occlusion

(2019) Davide Strambo et al.   STROKE

HHV-6A infection induces amyloid-beta expression and activation of microglial cells

(2019) Daria Bortolotti et al.   Alzheimers Research & Therapy

No effects without causes: the Iron Dysregulation and Dormant Microbes hypothesis for chronic, inflammatory diseases

(2018) Douglas B. Kell et al.   BIOLOGICAL REVIEWS

Disseminated intravascular coagulation

(2018) Jae C. Chang   BLOOD COAGULATION & FIBRINOLYSIS

Translational opportunities for amyloid-targeting fluorophores

(2018) Kevin J. Cao et al.   CHEMICAL COMMUNICATIONS

The differential diagnosis and treatment of thrombotic microangiopathies

(2018) Martin Bommer et al.   Deutsches Arzteblatt International

Both lipopolysaccharide and lipoteichoic acids potently induce anomalous fibrin amyloid formation: assessment with novel Amytracker™ stains

(2018) Etheresia Pretorius et al.   Journal of the Royal Society Interface

Prions, prionoids and protein misfolding disorders

(2018) Claudia Scheckel et al.   NATURE REVIEWS GENETICS

Alzheimer’s Disease-Associated β-Amyloid Is Rapidly Seeded by Herpesviridae to Protect against Brain Infection

(2018) William A. Eimer et al.   NEURON

Lipopolysaccharide-binding protein (LBP) can reverse the amyloid state of fibrin seen or induced in Parkinson's disease

(2018) Etheresia Pretorius et al.   PLoS One

The Physiological Roles of Amyloid-β Peptide Hint at New Ways to Treat Alzheimer's Disease

(2018) Holly M. Brothers et al.   Frontiers in Aging Neuroscience

Prion infectivity is encoded exclusively within the structure of proteinase K-resistant fragments of synthetically generated recombinant PrPSc

(2018) Fei Wang et al.   Acta Neuropathologica Communications

Diffuse parenchymal pulmonary amyloidosis associated with multiple myeloma: a case report and systematic review of the literature

(2018) Yin Liu et al.   BMC CANCER

Investigation of α-Synuclein Amyloid Fibrils Using the Fluorescent Probe Thioflavin T

(2018) Anna Sulatskaya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Local vs. systemic pulmonary amyloidosis—impact on diagnostics and clinical management

(2018) Julius-Valentin Baumgart et al.   VIRCHOWS ARCHIV

The Potential of LPS-Binding Protein to Reverse Amyloid Formation in Plasma Fibrin of Individuals With Alzheimer-Type Dementia

(2018) Etheresia Pretorius et al.   Frontiers in Aging Neuroscience

Implications of deranged activated partial thromboplastin time for anaesthesia and surgery

(2018) E. Loizou et al.   ANAESTHESIA

Next generation viscoelasticity assays in cardiothoracic surgery: Feasibility of the TEG6s system

(2018) Gabor Erdoes et al.   PLoS One

Correlative Light-Electron Microscopy detects lipopolysaccharide and its association with fibrin fibres in Parkinson’s Disease, Alzheimer’s Disease and Type 2 Diabetes Mellitus

(2018) Greta M. de Waal et al.   Scientific Reports

Binding of Thioflavin T and Related Probes to Polymorphic Models of Amyloid-β Fibrils

(2017) Francesca Peccati et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Proteins behaving badly. Substoichiometric molecular control and amplification of the initiation and nature of amyloid fibril formation: lessons from and for blood clotting

(2017) Douglas B. Kell et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Lipopolysaccharide-binding protein (LBP) reverses the amyloid state of fibrin seen in plasma of type 2 diabetics with cardiovascular co-morbidities

(2017) Etheresia Pretorius et al.   Scientific Reports

Major involvement of bacterial components in rheumatoid arthritis and its accompanying oxidative stress, systemic inflammation and hypercoagulability

(2016) Etheresia Pretorius et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microbes and Alzheimer’s Disease

(2016) Ruth F. Itzhaki et al.   JOURNAL OF ALZHEIMERS DISEASE

Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach

(2016) Thomas J. Paul et al.   Journal of Physical Chemistry Letters

Acute induction of anomalous and amyloidogenic blood clotting by molecular amplification of highly substoichiometric levels of bacterial lipopolysaccharide

(2016) Etheresia Pretorius et al.   Journal of the Royal Society Interface

Post-Ebola syndrome

(2016) Talha Khan Burki   LANCET INFECTIOUS DISEASES

Mammalian prions and their wider relevance in neurodegenerative diseases

(2016) John Collinge   NATURE

Structure of aggregates revealed

(2016) Robert Tycko   NATURE

How to Assess Fibrinogen Levels and Fibrin Clot Properties in Clinical Practice?

(2016) Anetta Undas   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Platelet Physiology

(2016) Andrew Frelinger et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

The clinical relevance of altered fibrinogen packaging in the presence of 17β-estradiol and progesterone

(2016) Albe C. Swanepoel et al.   THROMBOSIS RESEARCH

Pregnancy-related thrombotic microangiopathies: Clues from complement biology

(2016) Fadi Fakhouri   TRANSFUSION AND APHERESIS SCIENCE

Poorly controlled type 2 diabetes is accompanied by significant morphological and ultrastructural changes in both erythrocytes and in thrombin-generated fibrin: implications for diagnostics

(2015) Etheresia Pretorius et al.   Cardiovascular Diabetology

Interplay between ultrastructural findings and atherothrombotic complications in type 2 diabetes mellitus

(2015) Prashilla Soma et al.   Cardiovascular Diabetology

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently

(2015) Andrew Currin et al.   CHEMICAL SOCIETY REVIEWS

The simultaneous occurrence of both hypercoagulability and hypofibrinolysis in blood and serum during systemic inflammation, and the roles of iron and fibrin(ogen)

(2015) Douglas B. Kell et al.   Integrative Biology

On the translocation of bacteria and their lipopolysaccharides between blood and peripheral locations in chronic, inflammatory diseases: the central roles of LPS and LPS-induced cell death

(2015) Douglas B. Kell et al.   Integrative Biology

Proteinase K and the structure of PrPSc: The good, the bad and the ugly

(2015) Christopher J. Silva et al.   VIRUS RESEARCH

Viscoelastic and ultrastructural characteristics of whole blood and plasma in Alzheimer-type dementia, and the possible role of bacterial lipopolysaccharides (LPS)

(2015) Janette Bester et al.   Oncotarget

CT staging and monitoring of fibrotic interstitial lung diseases in clinical practice and treatment trials: a Position Paper from the Fleischner society

(2015) David M Hansell et al.   Lancet Respiratory Medicine

An imidazole functionalized pentameric thiophene displays different staining patterns in normal and malignant cells

(2015) Karin Magnusson et al.   Frontiers in Chemistry

Use and Utility of Hemostatic Screening in Adults Undergoing Elective, Non-Cardiac Surgery

(2015) Isabel A. Weil et al.   PLoS One

Iron-enhanced coagulation is attenuated by chelation A thrombelastographic and ultrastructural analysis

(2014) Vance G. Nielsen et al.   BLOOD COAGULATION & FIBRINOLYSIS

Letter to Editors Iron-induced fibrin formation may explain vascular pathology in Alzheimer’s disease

(2014) Boguslaw Lipinski et al.   FOLIA NEUROPATHOLOGICA

Diagnostic morphology: biophysical indicators for iron-driven inflammatory diseases

(2014) Etheresia Pretorius et al.   Integrative Biology

Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells

(2014) Douglas B. Kell et al.   Metallomics

Estrogen causes ultrastructural changes of fibrin networks during the menstrual cycle: A qualitative investigation

(2014) Albe C. Swanepoel et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Part 2: Ultrastructural changes of fibrin networks during three phases of pregnancy: A qualitative investigation

(2014) Albe C. Swanepoel et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Profound Morphological Changes in the Erythrocytes and Fibrin Networks of Patients with Hemochromatosis or with Hyperferritinemia, and Their Normalization by Iron Chelators and Other Agents

(2014) Etheresia Pretorius et al.   PLoS One

Multimodal fluorescence microscopy of prion strain specific PrP deposits stained by thiophene-based amyloid ligands

(2014) Karin Magnusson et al.   Prion

Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia

(2014) I. A. Buhimschi et al.   Science Translational Medicine

Hereditary amyloidosis caused by R554L fibrinogen Aα-chain mutation in a Spanish family and review of the literature

(2013) Michael Haidinger et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

The Influence of Laboratory Coagulation Tests and Clotting Factor Levels on Rotation Thromboelastometry (ROTEM®) During Major Surgery with Hemorrhage

(2013) Oliver M. Theusinger et al.   ANESTHESIA AND ANALGESIA

Systemic Amyloidoses

(2013) Luis M. Blancas-Mejía et al.   Annual Review of Biochemistry

Systemic amyloidoses: What an internist should know

(2013) Giovanni Palladini et al.   European Journal of Internal Medicine

The Role of Iron-Induced Fibrin in the Pathogenesis of Alzheimer’s Disease and the Protective Role of Magnesium

(2013) Boguslaw Lipinski et al.   Frontiers in Human Neuroscience

Unusual clotting dynamics of plasma supplemented with iron(III)

(2013) JERZY JANKUN et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Thrombotic microangiopathies

(2013) Michael H. Rosove   SEMINARS IN ARTHRITIS AND RHEUMATISM

Albumin Stabilizes Fibrin Fiber Ultrastructure in Low Serum Albumin Type 2 Diabetes

(2013) Etheresia Pretorius et al.   ULTRASTRUCTURAL PATHOLOGY

Molecular Rotors: What Lies Behind the High Sensitivity of the Thioflavin-T Fluorescent Marker

(2012) Nadav Amdursky et al.   ACCOUNTS OF CHEMICAL RESEARCH

Spectral Discrimination of Cerebral Amyloid Lesions after Peripheral Application of Luminescent Conjugated Oligothiophenes

(2012) Bettina M. Wegenast-Braun et al.   AMERICAN JOURNAL OF PATHOLOGY

Luminescent conjugated poly- and oligo-thiophenes: optical ligands for spectral assignment of a plethora of protein aggregates

(2012) Therése Klingstedt et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The α-Helix to β-Sheet Transition in Stretched and Compressed Hydrated Fibrin Clots

(2012) Rustem I. Litvinov et al.   BIOPHYSICAL JOURNAL

Differences in Morphology of Fibrin Clots Induced with Thrombin and Ferric Ions and Its Pathophysiological Consequences

(2012) E. Pretorius et al.   Heart Lung and Circulation

Rotational Thromboelastometry (ROTEM)-Based Coagulation Management in Cardiac Surgery and Major Trauma

(2012) Kenichi A. Tanaka et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Interaction of Thioflavin T with Amyloid Fibrils: Fluorescence Quantum Yield of Bound Dye

(2012) Anna I. Sulatskaya et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Novel Use of Scanning Electron Microscopy for Detection of Iron-Induced Morphological Changes in Human Blood

(2012) Etheresia Pretorius et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Iron enhances generation of fibrin fibers in human blood: Implications for pathogenesis of stroke

(2012) Boguslaw Lipinski et al.   MICROSCOPY RESEARCH AND TECHNIQUE

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On Typing Amyloidosis Using Immunohistochemistry. Detailled Illustrations, Review and a Note on Mass Spectrometry

(2012) Reinhold P. Linke   PROGRESS IN HISTOCHEMISTRY AND CYTOCHEMISTRY

Qualitative scanning electron microscopy analysis of fibrin networks and platelet abnormalities in diabetes

(2011) Etheresia Pretorius et al.   BLOOD COAGULATION & FIBRINOLYSIS

Standardization of thromboelastography: a report from the TEG-ROTEM working group

(2011) M. CHITLUR et al.   HAEMOPHILIA

Scanning electron microscopy of fibrin networks in rheumatoid arthritis: a qualitative analysis

(2011) Etheresia Pretorius et al.   RHEUMATOLOGY INTERNATIONAL

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson’s, Huntington’s, Alzheimer’s, prions, bactericides, chemical toxicology and others as examples

(2010) Douglas B. Kell   ARCHIVES OF TOXICOLOGY

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Fibrinogen and β-Amyloid Association Alters Thrombosis and Fibrinolysis: A Possible Contributing Factor to Alzheimer's Disease

(2010) Marta Cortes-Canteli et al.   NEURON

The TEG®vs the ROTEM®thromboelastography/thromboelastometry systems

(2009) G. N. B. Jackson et al.   ANAESTHESIA

Rheumatoid arthritis, Proteus, anti-CCP antibodies and Karl Popper

(2009) Alan Ebringer et al.   AUTOIMMUNITY REVIEWS

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

(2009) Douglas B Kell   BMC Medical Genomics

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Pathogenesis of Thrombotic Microangiopathies

(2008) X. Long Zheng et al.   Annual Review of Pathology-Mechanisms of Disease

Optical properties of amyloid stained by Congo red: History and mechanisms

(2008) Alexander J. Howie et al.   MICRON