G-quadruplex-based CRISPR photoswitch for spatiotemporal control of genomic modulation

Supramolecular CRISPR-OFF switches with host–guest chemistry

(2022) Wei Xiong et al.   NUCLEIC ACIDS RESEARCH

Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage

(2022) Stephan Riesenberg et al.   Nature Communications

Structural basis for mismatch surveillance by CRISPR–Cas9

(2022) Jack P. K. Bravo et al.   NATURE

CRISPR–Cas9 bends and twists DNA to read its sequence

(2022) Joshua C. Cofsky et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation

(2022) Nicholas G Economos et al.   NUCLEIC ACIDS RESEARCH

Rational guide RNA engineering for small-molecule control of CRISPR/Cas9 and gene editing

(2022) Xingyu Liu et al.   NUCLEIC ACIDS RESEARCH

Precision targeting tumor cells using cancer-specific InDel mutations with CRISPR-Cas9

(2022) Taejoon Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cas9 exo-endonuclease eliminates chromosomal translocations during genome editing

(2022) Jianhang Yin et al.   Nature Communications

R-loop formation and conformational activation mechanisms of Cas9

(2022) Martin Pacesa et al.   NATURE

G-quadruplex-guided RNA engineering to modulate CRISPR-based genomic regulation

(2022) Xingyu Liu et al.   NUCLEIC ACIDS RESEARCH

Endogenous promoter-driven sgRNA for monitoring the expression of low-abundance transcripts and lncRNAs

(2021) Ni Gao et al.   NATURE CELL BIOLOGY

Cas9 deactivation with photocleavable guide RNAs

(2021) Roger S. Zou et al.   MOLECULAR CELL

Targeting G-quadruplex Forming Sequences with Cas9

(2021) Hamza Balci et al.   ACS Chemical Biology

Non‐invasive Regulation of Cellular Morphology Using a Photoswitchable Mechanical DNA Polymer

(2021) Soumya Sethi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CRISPR/Cas9‐2D Silicene Gene‐Editing Nanosystem for Remote NIR‐II‐Induced Tumor Microenvironment Reprogramming and Augmented Photonic Tumor Ablation

(2021) Haohao Yin et al.   ADVANCED FUNCTIONAL MATERIALS

Engineering Photoresponsive Ligand Tethers for Mechanical Regulation of Stem Cells

(2021) Junsheng Zhang et al.   ADVANCED MATERIALS

Single‐Cell Visualization of Monogenic RNA G‐quadruplex and Occupied G‐quadruplex Ratio through a Module‐Assembled Multifunctional Probes Assay (MAMPA)

(2021) Yicong Dai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

UFMylation of MRE11 is essential for telomere length maintenance and hematopoietic stem cell survival

(2021) Lara Lee et al.   Science Advances

Conditional control of RNA-guided nucleic acid cleavage and gene editing

(2020) Shao-Ru Wang et al.   Nature Communications

Spatiotemporal Control of CRISPR/Cas9 Function in Cells and Zebrafish using Light‐Activated Guide RNA

(2020) Wenyuan Zhou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation

(2020) Elena V. Moroz-Omori et al.   ACS Central Science

Activatable CRISPR Transcriptional Circuits Lighted up by Fluorescent RNA for mRNA Sensing and Silencing

(2020) Zhan-Ming Ying et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optical Control of CRISPR‐Cas9 system for gene editing using photolabile crRNA

(2020) Yu Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Programmable live‐cell CRISPR imaging with toehold switch‐mediated strand displacement reactions

(2020) Yaya Hao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Very fast CRISPR on demand

(2020) Yang Liu et al.   SCIENCE

Aptamer‐Mediated Reversible Transactivation of Gene Expression by Light

(2020) Christian Renzl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CRISPRoff enables spatio-temporal control of CRISPR editing

(2020) Jared Carlson-Stevermer et al.   Nature Communications

Rethinking organoid technology through bioengineering

(2020) Elena Garreta et al.   NATURE MATERIALS

Increasing the specificity of CRISPR systems with engineered RNA secondary structures

(2019) D. Dewran Kocak et al.   NATURE BIOTECHNOLOGY

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

(2019) Kale Kundert et al.   Nature Communications

A Photolabile Semiconducting Polymer Nanotransducer for Near-Infrared Regulation of CRISPR/Cas9 Gene Editing

(2019) Yan Lyu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A G-quadruplex motif at the 3′ end of sgRNAs improves CRISPR–Cas9 based genome editing efficiency

(2018) Smita Nahar et al.   CHEMICAL COMMUNICATIONS

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Spatial control of in vivo CRISPR–Cas9 genome editing via nanomagnets

(2018) Haibao Zhu et al.   Nature Biomedical Engineering

Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing

(2017) Hao Yin et al.   NATURE BIOTECHNOLOGY

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

(2016) Piyush K. Jain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs

(2016) Mohammad A. Mandegar et al.   Cell Stem Cell

Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity

(2016) Duy P. Nguyen et al.   Nature Communications

Chemically modified guide RNAs enhance CRISPR-Cas genome editing in human primary cells

(2015) Ayal Hendel et al.   NATURE BIOTECHNOLOGY

Photoactivatable CRISPR-Cas9 for optogenetic genome editing

(2015) Yuta Nihongaki et al.   NATURE BIOTECHNOLOGY

Small molecule–triggered Cas9 protein with improved genome-editing specificity

(2015) Kevin M Davis et al.   Nature Chemical Biology

CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

(2015) Miguel A Moreno-Mateos et al.   NATURE METHODS

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

(2014) Hiroshi Nishimasu et al.   CELL

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

(2014) Federico González et al.   Cell Stem Cell

Easy quantitative assessment of genome editing by sequence trace decomposition

(2014) Eva K. Brinkman et al.   NUCLEIC ACIDS RESEARCH

Aptamer photoregulation in vivo

(2014) Lele Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression

(2013) Lei S. Qi et al.   CELL

Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity

(2013) F. Ann Ran et al.   CELL

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

(2013) Vikram Pattanayak et al.   NATURE BIOTECHNOLOGY

RNA-guided gene activation by CRISPR-Cas9–based transcription factors

(2013) Pablo Perez-Pinera et al.   NATURE METHODS

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Structure of Propeller-Type Parallel-Stranded RNA G-Quadruplexes, Formed by Human Telomeric RNA Sequences in K+Solution

(2009) Herry Martadinata et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE