Antispacer peptide nucleic acids for sequence-specific CRISPR-Cas9 modulation

Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair

(2020) Nicholas G. Economos et al.   MOLECULES

Anti-CRISPR protein applications: natural brakes for CRISPR-Cas technologies

(2020) Nicole D. Marino et al.   NATURE METHODS

A phage-encoded anti-CRISPR enables complete evasion of type VI-A CRISPR-Cas immunity

(2020) Alexander J. Meeske et al.   SCIENCE

Controlling and enhancing CRISPR systems

(2020) Haridha Shivram et al.   Nature Chemical Biology

Efficient cell penetration and delivery of peptide nucleic acids by an argininocalix[4]arene

(2019) Jessica Gasparello et al.   Scientific Reports

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9

(2019) Basudeb Maji et al.   CELL

Increasing the specificity of CRISPR systems with engineered RNA secondary structures

(2019) D. Dewran Kocak et al.   NATURE BIOTECHNOLOGY

Rationally Designed Small Nucleic Acid-Based Inhibitors of CRISPR-Cas9

(2019) Christopher L. Barkau et al.   Nucleic Acid Therapeutics

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Discovery of widespread Type I and Type V CRISPR-Cas inhibitors

(2018) Nicole D. Marino et al.   SCIENCE

Peptide nucleic acids: Advanced tools for biomedical applications

(2017) Anjali Gupta et al.   JOURNAL OF BIOTECHNOLOGY

Improving CRISPR–Cas specificity with chemical modifications in single-guide RNAs

(2017) Daniel E Ryan et al.   NUCLEIC ACIDS RESEARCH

Disabling Cas9 by an anti-CRISPR DNA mimic

(2017) Jiyung Shin et al.   Science Advances

Focus on PNA Flexibility and RNA Binding using Molecular Dynamics and Metadynamics

(2017) Massimiliano Donato Verona et al.   Scientific Reports

Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA

(2016) Christopher D Richardson et al.   NATURE BIOTECHNOLOGY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery

(2016) Raman Bahal et al.   Nature Communications

A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation

(2016) Iman Farasat et al.   PLoS Computational Biology

Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers

(2015) Isaac B Hilton et al.   NATURE BIOTECHNOLOGY

Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

(2015) Xiao-Hui Zhang et al.   Molecular Therapy-Nucleic Acids

Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

(2014) Carolin Anders et al.   NATURE

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

(2014) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

DNA targeting specificity of RNA-guided Cas9 nucleases

(2013) Patrick D Hsu et al.   NATURE BIOTECHNOLOGY

Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice

(2013) Erica B Schleifman et al.   Molecular Therapy-Nucleic Acids

Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo

(2012) N A McNeer et al.   GENE THERAPY

Modulation of the Biological Activity of microRNA-210 with Peptide Nucleic Acids (PNAs)

(2011) Enrica Fabbri et al.   ChemMedChem

Gene Targeting and Expression Modulation by Peptide Nucleic Acids (PNA)

(2010) Peter E. Nielsen   CURRENT PHARMACEUTICAL DESIGN

Nanoparticles Deliver Triplex-forming PNAs for Site-specific Genomic Recombination in CD34+ Human Hematopoietic Progenitors

(2010) Nicole A McNeer et al.   MOLECULAR THERAPY

Single Acute-Dose and Repeat-Doses Toxicity of anti-HIV-1 PNATAR–Penetratin Conjugate after Intraperitoneal Administration to Mice

(2008) Binay Chaubey et al.   OLIGONUCLEOTIDES