Supramolecular CRISPR-OFF switches with host–guest chemistry

A general supramolecular approach to regulate protein functions by cucurbit[7]uril and unnatural amino acid recognition

(2021) Wenbing Cao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intrinsic and Extrinsic Control of the pKa of Thiol Guests inside Yoctoliter Containers

(2020) Xiaoyang Cai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potent CRISPR-Cas9 inhibitors fromStaphylococcusgenomes

(2020) Kyle E. Watters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiplexed CRISPR technologies for gene editing and transcriptional regulation

(2020) Nicholas S. McCarty et al.   Nature Communications

CRISPRoff enables spatio-temporal control of CRISPR editing

(2020) Jared Carlson-Stevermer et al.   Nature Communications

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9

(2019) Basudeb Maji et al.   CELL

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

(2019) Kale Kundert et al.   Nature Communications

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

(2019) Stephanie Panier et al.   MOLECULAR CELL

RNA Cloaking by Reversible Acylation

(2018) Anastasia Kadina et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

RNA Control by Photoreversible Acylation

(2018) Willem A. Velema et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The CRISPR tool kit for genome editing and beyond

(2018) Mazhar Adli   Nature Communications

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

(2018) Johnny H. Hu et al.   NATURE

Directed evolution of CRISPR-Cas9 to increase its specificity

(2018) Jungjoon K. Lee et al.   Nature Communications

Cucurbit[7]uril-Driven Host–Guest Chemistry for Reversible Intervention of 5-Formylcytosine-Targeted Biochemical Reactions

(2017) Shao-Ru Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diversity and evolution of class 2 CRISPR–Cas systems

(2017) Sergey Shmakov et al.   NATURE REVIEWS MICROBIOLOGY

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

Disabling Cas9 by an anti-CRISPR DNA mimic

(2017) Jiyung Shin et al.   Science Advances

Development of Light-Activated CRISPR Using Guide RNAs with Photocleavable Protectors

(2016) Piyush K. Jain et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Naturally Occurring Off-Switches for CRISPR-Cas9

(2016) April Pawluk et al.   CELL

Cucurbit[7]uril–Tetramethylrhodamine Conjugate for Direct Sensing and Cellular Imaging

(2016) Andrew T. Bockus et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

(2016) Alexandra East-Seletsky et al.   NATURE

Small-molecule control of protein function through Staudinger reduction

(2016) Ji Luo et al.   Nature Chemistry

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Molecular Recognition in Chemical and Biological Systems

(2015) Elke Persch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cucurbituril-Based Molecular Recognition

(2015) Steven J. Barrow et al.   CHEMICAL REVIEWS

Binding Hydrated Anions with Hydrophobic Pockets

(2015) Punidha Sokkalingam et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Optical Control of CRISPR/Cas9 Gene Editing

(2015) James Hemphill et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cas9 specifies functional viral targets during CRISPR–Cas adaptation

(2015) Robert Heler et al.   NATURE

Small molecule–triggered Cas9 protein with improved genome-editing specificity

(2015) Kevin M Davis et al.   Nature Chemical Biology

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

(2015) Gulen Yesilbag Tonga et al.   Nature Chemistry

CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells

(2015) Wulan Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimuli-Responsive Supramolecular Polymers in Aqueous Solution

(2014) Xiang Ma et al.   ACCOUNTS OF CHEMICAL RESEARCH

Stimuli Responsive Systems Constructed Using Cucurbit[n]uril-Type Molecular Containers

(2014) Lyle Isaacs   ACCOUNTS OF CHEMICAL RESEARCH

Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

(2014) Hiroshi Nishimasu et al.   CELL

An iCRISPR Platform for Rapid, Multiplexable, and Inducible Genome Editing in Human Pluripotent Stem Cells

(2014) Federico González et al.   Cell Stem Cell

Broccoli: Rapid Selection of an RNA Mimic of Green Fluorescent Protein by Fluorescence-Based Selection and Directed Evolution

(2014) Grigory S. Filonov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

(2014) Yuexin Zhou et al.   NATURE

Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation

(2014) M. Jinek et al.   SCIENCE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

crRNA and tracrRNA guide Cas9-mediated DNA interference inStreptococcus thermophilus

(2013) Tautvydas Karvelis et al.   RNA Biology

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Stimuli-responsive supramolecular polymeric materials

(2012) Xuzhou Yan et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and Self-Assembly Processes of Monofunctionalized Cucurbit[7]uril

(2012) Brittany Vinciguerra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Effect of the damping function in dispersion corrected density functional theory

(2011) Stefan Grimme et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The uses of supramolecular chemistry in synthetic methodology development: examples of anion and neutral molecular recognition

(2010) Leo A. Joyce et al.   CHEMICAL SOCIETY REVIEWS

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

Supramolecular fishing for plasma membrane proteins using an ultrastable synthetic host–guest binding pair

(2010) Don-Wook Lee et al.   Nature Chemistry

Cucurbituril complexes cross the cell membrane

(2009) Pedro Montes-Navajas et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES