Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Published 2023 View Full Article
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Title
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Authors
Keywords
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Journal
NATURE
Volume 615, Issue 7952, Pages 490-498
Publisher
Springer Science and Business Media LLC
Online
2023-03-09
DOI
10.1038/s41586-023-05720-6
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Note: Only part of the references are listed.- Fumarate induces vesicular release of mtDNA to drive innate immunity
- (2023) Vincent Zecchini et al. NATURE
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- (2022) Anna Eisenstein et al. IMMUNITY
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- (2022) Leah K. Billingham et al. NATURE IMMUNOLOGY
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- (2022) Qin Li et al. NATURE
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- (2022) Sujin Kim et al. Cell Reports
- Inflammaging is driven by upregulation of innate immune receptors and systemic interferon signaling and is ameliorated by dietary restriction
- (2022) Seyed Mohammad Mahdi Rasa et al. Cell Reports
- Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
- (2021) Daniel R. Crooks et al. Science Signaling
- Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance
- (2021) Marco Tigano et al. NATURE
- IRGM1 links mitochondrial quality control to autoimmunity
- (2021) Prashant Rai et al. NATURE IMMUNOLOGY
- Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis
- (2021) Yi-Ping Wang et al. Cell Metabolism
- MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights
- (2021) Zhiqiang Pang et al. NUCLEIC ACIDS RESEARCH
- Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1α in lipopolysaccharide-activated macrophages
- (2021) Niamh C. Williams et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection
- (2021) Pamela Sarkar et al. Multiple Sclerosis Journal
- SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells
- (2021) Ying Wang et al. NATURE
- Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism
- (2021) Dylan Gerard Ryan et al. eLife
- Succination inactivates gasdermin D and blocks pyroptosis
- (2020) Fiachra Humphries et al. SCIENCE
- GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance
- (2019) Harding H. Luan et al. CELL
- LFQ-Analyst: An Easy-To-Use Interactive Web Platform To Analyze and Visualize Label-Free Proteomics Data Preprocessed with MaxQuant
- (2019) Anup D. Shah et al. JOURNAL OF PROTEOME RESEARCH
- 4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects
- (2019) Shan-Ting Liao et al. Nature Communications
- GDF15 mediates the effects of metformin on body weight and energy balance
- (2019) Anthony P. Coll et al. NATURE
- Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
- (2018) Michael D. Kornberg et al. SCIENCE
- BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
- (2018) Kate McArthur et al. SCIENCE
- Mitochondrial double-stranded RNA triggers antiviral signalling in humans
- (2018) Ashish Dhir et al. NATURE
- Parkin and PINK1 mitigate STING-induced inflammation
- (2018) Danielle A. Sliter et al. NATURE
- Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis
- (2018) Monika Bambouskova et al. NATURE
- Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
- (2018) Evanna L. Mills et al. NATURE
- Targeting STING with covalent small-molecule inhibitors
- (2018) Simone M. Haag et al. NATURE
- Dimethyl fumarate mediates Nrf2-dependent mitochondrial biogenesis in mice and humans
- (2017) Genki Hayashi et al. HUMAN MOLECULAR GENETICS
- Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
- (2017) Petros A. Tyrakis et al. Cell Reports
- Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
- (2016) Evanna L. Mills et al. CELL
- Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation
- (2016) Vicky Lampropoulou et al. Cell Metabolism
- Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
- (2016) Rob J.W. Arts et al. Cell Metabolism
- Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels
- (2016) Thekla Cordes et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus
- (2016) Simone Caielli et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition
- (2016) Marco Sciacovelli et al. NATURE
- Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
- (2016) Maxim V. Kuleshov et al. NUCLEIC ACIDS RESEARCH
- Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus
- (2016) Iwona A. Buskiewicz et al. Science Signaling
- Reactive oxygen species induce virus-independent MAVS oligomerization in systemic lupus erythematosus
- (2016) Iwona A. Buskiewicz et al. Science Signaling
- Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA
- (2015) A. Kru ger et al. EMBO REPORTS
- Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization
- (2015) Abhishek K. Jha et al. IMMUNITY
- Identification of Fumarate Hydratase Inhibitors with Nutrient-Dependent Cytotoxicity
- (2015) Toshifumi Takeuchi et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mitochondrial DNA stress primes the antiviral innate immune response
- (2015) A. Phillip West et al. NATURE
- Fumarate induces redox-dependent senescence by modifying glutathione metabolism
- (2015) Liang Zheng et al. Nature Communications
- Atherosclerosis and cardiovascular disease in systemic lupus erythematosus: effects of in vivo statin treatment
- (2014) Patricia Ruiz-Limon et al. ANNALS OF THE RHEUMATIC DISEASES
- The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling
- (2014) Karthigayan Shanmugasundaram et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
- (2013) Lucas B. Sullivan et al. MOLECULAR CELL
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia
- (2013) Julie Adam et al. Cell Reports
- Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
- (2013) Nicola Ternette et al. Cell Reports
- 5,6-Dimethylxanthenone-4-acetic Acid (DMXAA) Activates Stimulator of Interferon Gene (STING)-dependent Innate Immune Pathways and Is Regulated by Mitochondrial Membrane Potential
- (2012) Daniel Prantner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Mitochondrial Membrane Potential Is Required for MAVS-Mediated Antiviral Signaling
- (2011) T. Koshiba et al. Science Signaling
- Differential expression analysis for sequence count data
- (2010) Simon Anders et al. GENOME BIOLOGY
- Inhibition of Activator Protein-1 by Sulforaphane Involves Interaction with Cysteine in the cFos DNA-Binding Domain: Implications for Chemoprevention of UVB-Induced Skin Cancer
- (2009) S. E. Dickinson et al. CANCER RESEARCH
- Downregulation of SRF–FOS–JUNB pathway in fumarate hydratase deficiency and in uterine leiomyomas
- (2009) N Raimundo et al. ONCOGENE
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