Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs

A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

(2021) Francesco Cilenti et al.   IMMUNITY

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response

(2021) Lee Mulderrig et al.   NATURE

GDF15 Induces Anorexia through Nausea and Emesis

(2020) Tito Borner et al.   Cell Metabolism

Renoprotective and Immunomodulatory Effects of GDF15 following AKI Invoked by Ischemia-Reperfusion Injury

(2020) Jing Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cardiovascular effects and safety of (non-aspirin) NSAIDs

(2020) Anne-Marie Schjerning et al.   Nature Reviews Cardiology

CXCL5-mediated recruitment of neutrophils into the peritoneal cavity of Gdf15-deficient mice protects against abdominal sepsis

(2020) Isa Santos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptation of the master antioxidant response connects metabolism, lifespan and feather development pathways in birds

(2020) Gianni M. Castiglione et al.   Nature Communications

Canagliflozin inhibits vascular smooth muscle cell proliferation and migration: Role of heme oxygenase-1

(2020) Ghazaleh Behnammanesh et al.   Redox Biology

NRF2 Augments Epidermal Antioxidant Defenses and Promotes Atopy

(2020) Tatsuya Ogawa et al.   JOURNAL OF IMMUNOLOGY

Canagliflozin attenuates isoprenaline-induced cardiac oxidative stress by stimulating multiple antioxidant and anti-inflammatory signaling pathways

(2020) Raquibul Hasan et al.   Scientific Reports

Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis

(2020) Mengtao Li et al.   BMJ Open

High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance

(2020) David B. Lombard et al.   Science Advances

GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

(2019) Satish Patel et al.   Cell Metabolism

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

(2019) Antonio Cuadrado et al.   NATURE REVIEWS DRUG DISCOVERY

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response

(2019) Ryuichi Nagashima et al.   JOURNAL OF IMMUNOLOGY

Sulforaphane treatment reverses corticosteroid resistance in a mixed granulocytic mouse model of asthma by upregulation of antioxidants and attenuation of Th17 immune responses in the airways

(2019) Naif O. Al-Harbi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activators and Inhibitors of NRF2: A Review of Their Potential for Clinical Development

(2019) Natalia Robledinos-Antón et al.   Oxidative Medicine and Cellular Longevity

GDF15 Is an Inflammation-Induced Central Mediator of Tissue Tolerance

(2019) Harding H. Luan et al.   CELL

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

Role of GDF15 in active lifestyle induced metabolic adaptations and acute exercise response in mice

(2019) Carla Igual Gil et al.   Scientific Reports

NRF2 and the Hallmarks of Cancer

(2018) Montserrat Rojo de la Vega et al.   CANCER CELL

Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs

(2018) Jinxu Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nrf2 at the heart of oxidative stress and cardiac protection

(2018) Qin M. Chen et al.   PHYSIOLOGICAL GENOMICS

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis

(2018) Masayuki Yamamoto et al.   PHYSIOLOGICAL REVIEWS

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

(2018) Kook Hwan Kim et al.   Scientific Reports

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

(2018) Sharadha Dayalan Naidu et al.   Scientific Reports

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

(2018) Evanna L. Mills et al.   NATURE

The Nrf2-Antioxidant Response Element Signaling Pathway Controls Fibrosis and Autoimmunity in Scleroderma

(2018) Niloufar Kavian et al.   Frontiers in Immunology

NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development

(2017) Nivedita M. Ratnam et al.   JOURNAL OF CLINICAL INVESTIGATION

Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis

(2017) Bruno R da Costa et al.   LANCET

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates

(2017) Shannon E Mullican et al.   NATURE MEDICINE

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

(2017) Toru Suzuki et al.   Cell Reports

Aspirin for the Prevention of Cancer Incidence and Mortality: Systematic Evidence Reviews for the U.S. Preventive Services Task Force

(2016) Jessica Chubak et al.   ANNALS OF INTERNAL MEDICINE

Risk of asthma exacerbation associated with nonsteroidal anti-inflammatory drugs in childhood asthma

(2016) Pei-Chia Lo et al.   MEDICINE

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

(2016) Eri H. Kobayashi et al.   Nature Communications

Comparative Effectiveness of Pharmacologic Interventions for Knee Osteoarthritis

(2015) Raveendhara R. Bannuru et al.   ANNALS OF INTERNAL MEDICINE

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response

(2015) Ryota Saito et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Nrf2 signaling and longevity in naturally long-lived rodents

(2015) Kaitlyn N. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bidirectional interactions between indomethacin and the murine intestinal microbiota

(2015) Xue Liang et al.   eLife

Prediction by Pharmacogenetics of Safety and Efficacy of Non-Steroidal Anti- Inflammatory Drugs: A Review

(2014) Victoria Rollason et al.   CURRENT DRUG METABOLISM

Comparative analysis of the efficiency and specificity of myeloid-Cre deleting strains using ROSA-EYFP reporter mice

(2014) Clare L. Abram et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Enhanced Longevity by Ibuprofen, Conserved in Multiple Species, Occurs in Yeast through Inhibition of Tryptophan Import

(2014) Chong He et al.   PLoS Genetics

NSAIDs Inhibit Tumorigenesis, but How?

(2013) Evrim Gurpinar et al.   CLINICAL CANCER RESEARCH

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

(2013) Dick de Zeeuw et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells

(2013) Roberta Foresti et al.   PHARMACOLOGICAL RESEARCH

The distribution of urate deposition within the extremities in gout: a review of 148 dual-energy CT cases

(2013) Paul I. Mallinson et al.   SKELETAL RADIOLOGY

COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs

(2013) Evrim Gurpinar et al.   Frontiers in Oncology

Validation of the multiple sensor mechanism of the Keap1-Nrf2 system

(2012) Kai Takaya et al.   FREE RADICAL BIOLOGY AND MEDICINE

Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity

(2011) Tsui-Ting Ching et al.   AGING CELL

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

(2011) Patricia McGettigan et al.   PLOS MEDICINE

Management of Chronic Nonmalignant Pain with Nonsteroidal Antiinflammatory Drugs

(2008) Christopher M Herndon et al.   PHARMACOTHERAPY