Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

(2021) Abigail S. Krall et al.   Cell Metabolism

The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals

(2021) Margaret E Torrence et al.   eLife

Mitochondrial NADP(H) generation is essential for proline biosynthesis

(2021) Jiajun Zhu et al.   SCIENCE

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

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A pathway coordinated by DELE1 relays mitochondrial stress to the cytosol

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Distinct mitochondrial defects trigger the integrated stress response depending on the metabolic state of the cell

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Small molecule ISRIB suppresses the integrated stress response within a defined window of activation

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LFQ-Analyst: An Easy-To-Use Interactive Web Platform To Analyze and Visualize Label-Free Proteomics Data Preprocessed with MaxQuant

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Golgi stress response reprograms cysteine metabolism to confer cytoprotection in Huntington’s disease

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Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

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Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects

(2017) Petros A. Tyrakis et al.   Cell Reports

Maturation of selected human mitochondrial tRNAs requires deadenylation

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The integrated stress response

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Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition

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Tumour-specific proline vulnerability uncovered by differential ribosome codon reading

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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

(2016) J. R. Mayers et al.   SCIENCE

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

(2016) Xiaoyan Robert Bao et al.   eLife

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

(2015) Kıvanç Birsoy et al.   CELL

Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells

(2015) Lucas B. Sullivan et al.   CELL

A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity

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Pyruvate carboxylation enables growth of SDH-deficient cells by supporting aspartate biosynthesis

(2015) Simone Cardaci et al.   NATURE CELL BIOLOGY

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation

(2015) Yuhui Jiang et al.   NATURE CELL BIOLOGY

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Asparagine Plays a Critical Role in Regulating Cellular Adaptation to Glutamine Depletion

(2014) Ji Zhang et al.   MOLECULAR CELL

Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects

(2014) Andrew R. Mullen et al.   Cell Reports

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

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A Role for Cytosolic Fumarate Hydratase in Urea Cycle Metabolism and Renal Neoplasia

(2013) Julie Adam et al.   Cell Reports

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress

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