IRGM1 links mitochondrial quality control to autoimmunity

Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression

(2019) Lodoe Lama et al.   Nature Communications

Transcriptional Regulation of Autophagy: Mechanisms and Diseases

(2019) Chiara Di Malta et al.   Frontiers in Cell and Developmental Biology

An update on the role of type I interferons in systemic lupus erythematosus and Sjögrenʼs syndrome

(2018) Gudny Ella Thorlacius et al.   CURRENT OPINION IN RHEUMATOLOGY

Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency

(2018) Aida Rodríguez‐Nuevo et al.   EMBO JOURNAL

Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins

(2018) Suresh Kumar et al.   JOURNAL OF CELL BIOLOGY

Two novel lncRNAs discovered in human mitochondrial DNA using PacBio full-length transcriptome data

(2018) Shan Gao et al.   MITOCHONDRION

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Crohn’s disease IRGM risk alleles are associated with altered gene expression in human tissues

(2018) Teminioluwa A. Ajayi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

(2018) Katerina Gkirtzimanaki et al.   Cell Reports

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo

(2018) Thomas G. McWilliams et al.   Open Biology

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

SNAPIN is critical for lysosomal acidification and autophagosome maturation in macrophages

(2016) Bo Shi et al.   Autophagy

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

(2016) Jelena Maric-Biresev et al.   BMC BIOLOGY

Autophagy-related IRGM genes confer susceptibility to ankylosing spondylitis in a Chinese female population: a case–control study

(2016) Q Xia et al.   GENES AND IMMUNITY

Lysosome acidification by photoactivated nanoparticles restores autophagy under lipotoxicity

(2016) Kyle M. Trudeau et al.   JOURNAL OF CELL BIOLOGY

Type I interferon–mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview

(2016) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism

(2016) Li He et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interferon-Inducible GTPases in Host Resistance, Inflammation and Disease

(2016) Danielle Pilla-Moffett et al.   JOURNAL OF MOLECULAR BIOLOGY

Induction of the type I interferon response in neurological forms of Gaucher disease

(2016) Einat B. Vitner et al.   Journal of Neuroinflammation

Noncanonical autophagy inhibits the autoinflammatory, lupus-like response to dying cells

(2016) Jennifer Martinez et al.   NATURE

Defects in lysosomal maturation facilitate the activation of innate sensors in systemic lupus erythematosus

(2016) Andrew J. Monteith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy

(2015) Anne Hamacher-Brady et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human TLR8 senses UR/URR motifs in bacterial and mitochondrial RNA

(2015) A. Kru ger et al.   EMBO REPORTS

Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS

(2015) Feng Ma et al.   JOURNAL OF IMMUNOLOGY

IRGM Governs the Core Autophagy Machinery to Conduct Antimicrobial Defense

(2015) Santosh Chauhan et al.   MOLECULAR CELL

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

(2015) Jennifer Martinez et al.   NATURE CELL BIOLOGY

Suppression of systemic autoimmunity by the innate immune adaptor STING

(2015) Shruti Sharma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA

(2014) Anthony Rongvaux et al.   CELL

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

(2013) Tiffany N Caza et al.   ANNALS OF THE RHEUMATIC DISEASES

Advances in understanding the pathogenesis of primary Sjögren's syndrome

(2013) Gaëtane Nocturne et al.   Nature Reviews Rheumatology

IRG and GBP Host Resistance Factors Target Aberrant, “Non-self” Vacuoles Characterized by the Missing of “Self” IRGM Proteins

(2013) Arun K. Haldar et al.   PLoS Pathogens

IFN-  Elicits Macrophage Autophagy via the p38 MAPK Signaling Pathway

(2012) T. Matsuzawa et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

(2012) Takafumi Oka et al.   NATURE

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling

(2011) K. Y. King et al.   BLOOD

A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery

(2011) Hiroyuki Katayama et al.   CHEMISTRY & BIOLOGY

Immunity-related GTPase M (IRGM) Proteins Influence the Localization of Guanylate-binding Protein 2 (GBP2) by Modulating Macroautophagy

(2011) Maria K. Traver et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Localisation and Mislocalisation of the Interferon-Inducible Immunity-Related GTPase, Irgm1 (LRG-47) in Mouse Cells

(2010) Yang O. Zhao et al.   PLoS One

The p47 GTPase Lrg-47 (Irgm1) Links Host Defense and Hematopoietic Stem Cell Proliferation

(2008) Carl G. Feng et al.   Cell Stem Cell

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE