Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development

LC3B is an RNA-binding protein to trigger rapid mRNA degradation during autophagy

(2022) Hyun Jung Hwang et al.   Nature Communications

Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation

(2020) Hyeseung Lee et al.   NEURON

Small-molecule inhibitors of human mitochondrial DNA transcription

(2020) Nina A. Bonekamp et al.   NATURE

Mechanisms and therapeutic implications of cellular senescence in osteoarthritis

(2020) Philip R. Coryell et al.   Nature Reviews Rheumatology

The Role of Autophagy in Osteoarthritis

(2020) Ran Duan et al.   Frontiers in Cell and Developmental Biology

Evidence of Aberrant Immune Response by Endogenous Double‐Stranded RNAs: Attack from Within

(2019) Sujin Kim et al.   BIOESSAYS

Stress-activated miR-204 governs senescent phenotypes of chondrocytes to promote osteoarthritis development

(2019) Donghyun Kang et al.   Science Translational Medicine

The Role of Autophagy in Chondrocyte Metabolism and Osteoarthritis: A Comprehensive Research Review

(2019) Pan Luo et al.   Biomed Research International

Mitochondrial Damage Causes Inflammation via cGAS-STING Signaling in Acute Kidney Injury

(2019) Hiroshi Maekawa et al.   Cell Reports

Mitochondrial double‐stranded RNA in exosome promotes interleukin‐17 production through toll‐like receptor 3 in alcoholic liver injury

(2019) Jun‐Hee Lee et al.   HEPATOLOGY

Mitochondrial DNA Transcription and Its Regulation: An Evolutionary Perspective

(2018) Gilad Barshad et al.   TRENDS IN GENETICS

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

(2018) Ching-Hou Ma et al.   Redox Biology

PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs

(2018) Yoosik Kim et al.   MOLECULAR CELL

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway

(2017) Changwei Li et al.   Cell Death & Disease

Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis

(2016) William H. Robinson et al.   Nature Reviews Rheumatology

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

(2016) Valentina Gandin et al.   Nature Communications

Influence of osteoarthritis grade on molecular signature of human cartilage

(2015) Shuanhu Zhou et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Autophagy Activation and Protection From Mitochondrial Dysfunction in Human Chondrocytes

(2015) Paloma López de Figueroa et al.   Arthritis & Rheumatology

PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator

(2014) Y. Kim et al.   GENES & DEVELOPMENT

Deletion of Human tarbp2 Reveals Cellular MicroRNA Targets and Cell-Cycle Function of TRBP

(2014) Yoosik Kim et al.   Cell Reports

Roles of eIF2α kinases in the pathogenesis of Alzheimer’s disease

(2014) Masuo Ohno   Frontiers in Molecular Neuroscience

Deletion of P58IPK, the Cellular Inhibitor of the Protein Kinases PKR and PERK, Causes Bone Changes and Joint Degeneration in Mice

(2014) Sophie J. Gilbert et al.   Frontiers in Endocrinology

Cerebrospinal Fluid PKR Level Predicts Cognitive Decline in Alzheimer’s Disease

(2013) Julien Dumurgier et al.   PLoS One

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Mechanism of PKR Activation by dsRNA

(2008) Peter A. Lemaire et al.   JOURNAL OF MOLECULAR BIOLOGY

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS