Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Mitochondrial DNA alterations underlie an irreversible shift to aerobic glycolysis in fumarate hydratase–deficient renal cancer
Authors
Keywords
-
Journal
Science Signaling
Volume 14, Issue 664, Pages eabc4436
Publisher
American Association for the Advancement of Science (AAAS)
Online
2021-01-06
DOI
10.1126/scisignal.abc4436
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Growth Rates of Genetically Defined Renal Tumors: Implications for Active Surveillance and Intervention
- (2020) Mark W. Ball et al. JOURNAL OF CLINICAL ONCOLOGY
- Tracing insights into de novo lipogenesis in liver and adipose tissues
- (2020) Martina Wallace et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The Metabolic Basis of Kidney Cancer
- (2019) W. Marston Linehan et al. Cancer Discovery
- Redox Chemistry in the Genome: Emergence of the [4Fe4S] Cofactor in Repair and Replication
- (2019) Jacqueline K. Barton et al. Annual Review of Biochemistry
- Growth factors stimulate anabolic metabolism by directing nutrient uptake
- (2019) Craig B. Thompson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- SnapShot: Mitochondrial Nucleoid
- (2018) Nina A. Bonekamp et al. CELL
- Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal
- (2018) Thomas J. Mitchell et al. CELL
- Oxygen Activation and Energy Conservation by Cytochrome c Oxidase
- (2018) Mårten Wikström et al. CHEMICAL REVIEWS
- Assembly of mammalian oxidative phosphorylation complexes I–V and supercomplexes
- (2018) Alba Signes et al. Essays in Biochemistry
- Spatial orchestration of mitochondrial translation and OXPHOS complex assembly
- (2018) Stefan Stoldt et al. NATURE CELL BIOLOGY
- Early loss of mitochondrial complex I and rewiring of glutathione metabolism in renal oncocytoma
- (2018) Raj K. Gopal et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity
- (2018) Michael D. Kornberg et al. SCIENCE
- ONC201 kills breast cancer cells in vitro by targeting mitochondria
- (2018) Yoshimi Endo Greer et al. Oncotarget
- The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
- (2018) Christopher J. Ricketts et al. Cell Reports
- Biogenesis and functions of mammalian iron-sulfur proteins in the regulation of iron homeostasis and pivotal metabolic pathways
- (2017) Tracey A. Rouault et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase
- (2017) Yugang Wang et al. NATURE
- Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing
- (2017) Ramon C. Sun et al. Nature Communications
- Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects
- (2017) Petros A. Tyrakis et al. Cell Reports
- Mitochondrial respiratory gene expression is suppressed in many cancers
- (2017) Ed Reznik et al. eLife
- Transcriptional Regulation by Nrf2
- (2017) Claudia Tonelli et al. ANTIOXIDANTS & REDOX SIGNALING
- Mutations in TFAM, encoding mitochondrial transcription factor A, cause neonatal liver failure associated with mtDNA depletion
- (2016) Ashlee R. Stiles et al. MOLECULAR GENETICS AND METABOLISM
- HmtDB 2016: data update, a better performing query system and human mitochondrial DNA haplogroup predictor
- (2016) Rosanna Clima et al. NUCLEIC ACIDS RESEARCH
- Mitochondrial Cristae: Where Beauty Meets Functionality
- (2016) Sara Cogliati et al. TRENDS IN BIOCHEMICAL SCIENCES
- 18-F fluorodeoxyglucose uptake in positron emission tomography as a pathological grade predictor for renal clear cell carcinomas
- (2015) Yoshifumi Noda et al. EUROPEAN RADIOLOGY
- SIFT missense predictions for genomes
- (2015) Robert Vaser et al. Nature Protocols
- Identification of protein succination as a novel modification of tubulin
- (2014) Gerardo G. Piroli et al. BIOCHEMICAL JOURNAL
- Trimmomatic: a flexible trimmer for Illumina sequence data
- (2014) Anthony M. Bolger et al. BIOINFORMATICS
- Targeting ABL1-Mediated Oxidative Stress Adaptation in Fumarate Hydratase-Deficient Cancer
- (2014) Carole Sourbier et al. CANCER CELL
- Cochaperone Binding to LYR Motifs Confers Specificity of Iron Sulfur Cluster Delivery
- (2014) Nunziata Maio et al. Cell Metabolism
- A Novel in-Frame 18-bp Microdeletion inMT-CYBCauses a Multisystem Disorder with Prominent Exercise Intolerance
- (2014) Valeria Carossa et al. HUMAN MUTATION
- Defects of Mitochondrial DNA Replication
- (2014) William C. Copeland JOURNAL OF CHILD NEUROLOGY
- Tracing Compartmentalized NADPH Metabolism in the Cytosol and Mitochondria of Mammalian Cells
- (2014) Caroline A. Lewis et al. MOLECULAR CELL
- Oxidation of Alpha-Ketoglutarate Is Required for Reductive Carboxylation in Cancer Cells with Mitochondrial Defects
- (2014) Andrew R. Mullen et al. Cell Reports
- voom: precision weights unlock linear model analysis tools for RNA-seq read counts
- (2014) Charity W Law et al. GENOME BIOLOGY
- Cellular Fatty Acid Metabolism and Cancer
- (2013) Erin Currie et al. Cell Metabolism
- TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication
- (2013) D. Milenkovic et al. HUMAN MOLECULAR GENETICS
- Predicting the molecular complexity of sequencing libraries
- (2013) Timothy Daley et al. NATURE METHODS
- Metabolic Reprogramming for Producing Energy and Reducing Power in Fumarate Hydratase Null Cells from Hereditary Leiomyomatosis Renal Cell Carcinoma
- (2013) Youfeng Yang et al. PLoS One
- Inhibition of Mitochondrial Aconitase by Succination in Fumarate Hydratase Deficiency
- (2013) Nicola Ternette et al. Cell Reports
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- GENCODE: The reference human genome annotation for The ENCODE Project
- (2012) J. Harrow et al. GENOME RESEARCH
- Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance
- (2012) Margaret M. Humble et al. HUMAN MOLECULAR GENETICS
- Predicting the Functional Effect of Amino Acid Substitutions and Indels
- (2012) Yongwook Choi et al. PLoS One
- The metabolic basis of kidney cancer
- (2012) W. Marston Linehan et al. SEMINARS IN CANCER BIOLOGY
- A novel fumarate hydratase-deficient HLRCC kidney cancer cell line, UOK268: a model of the Warburg effect in cancer
- (2012) Youfeng Yang et al. Cancer Genetics
- RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
- (2011) Bo Li et al. BMC BIOINFORMATICS
- The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels
- (2011) Wing-Hang Tong et al. CANCER CELL
- An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma
- (2011) Aikseng Ooi et al. CANCER CELL
- Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
- (2011) Julie Adam et al. CANCER CELL
- Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status
- (2011) Chiara Bardella et al. JOURNAL OF PATHOLOGY
- Reductive carboxylation supports growth in tumour cells with defective mitochondria
- (2011) Andrew R. Mullen et al. NATURE
- Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase
- (2011) Christian Frezza et al. NATURE
- Predicting the functional impact of protein mutations: application to cancer genomics
- (2011) Boris Reva et al. NUCLEIC ACIDS RESEARCH
- Clues from cell metabolism
- (2010) William G. Kaelin et al. NATURE
- A method and server for predicting damaging missense mutations
- (2010) Ivan A Adzhubei et al. NATURE METHODS
- UOK 262 cell line, fumarate hydratase deficient (FH−/FH−) hereditary leiomyomatosis renal cell carcinoma: in vitro and in vivo model of an aberrant energy metabolic pathway in human cancer
- (2009) Youfeng Yang et al. CANCER GENETICS AND CYTOGENETICS
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started