The Oncometabolite Fumarate Promotes Pseudohypoxia Through Noncanonical Activation of NF-κB Signaling

The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling

(2013) Lucas B. Sullivan et al.   MOLECULAR CELL

Structural Insights into the Functions of TBK1 in Innate Antimicrobial Immunity

(2013) Chang Shu et al.   STRUCTURE

Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε

(2012) Jessica E. Hutti et al.   PLoS One

Tissue Transglutaminase Constitutively Activates HIF-1α Promoter and Nuclear Factor-κB via a Non-Canonical Pathway

(2012) Santosh Kumar et al.   PLoS One

The Glycolytic Shift in Fumarate-Hydratase-Deficient Kidney Cancer Lowers AMPK Levels, Increases Anabolic Propensities and Lowers Cellular Iron Levels

(2011) Wing-Hang Tong et al.   CANCER CELL

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism

(2010) Linda O'Flaherty et al.   HUMAN MOLECULAR GENETICS

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1  Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species

(2009) S. Sudarshan et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

(2009) David A. Barbie et al.   NATURE

Regulation of hypoxia-inducible factor-1α by NF-κB

(2008) Patrick van Uden et al.   BIOCHEMICAL JOURNAL

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE