Reduced expression of mitochondrial fumarate hydratase in progressive multiple sclerosis contributes to impaired in vitro mesenchymal stromal cell-mediated neuroprotection

HIF-1α in the Crosstalk Between Reactive Oxygen Species and Autophagy Process: A Review in Multiple Sclerosis

(2021) Rezvan Asgari et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

The immunologic Warburg effect: Evidence and therapeutic opportunities in autoimmunity

(2020) Michael D. Kornberg   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Targeting Keap1/Nrf2/ARE signaling pathway in multiple sclerosis

(2020) Danica Michaličková et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HIF1α‐dependent metabolic reprogramming governs mesenchymal stem/stromal cell immunoregulatory functions

(2020) Rafael Contreras‐Lopez et al.   FASEB JOURNAL

MEsenchymal StEm cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis

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Reduced neuroprotective potential of the mesenchymal stromal cell secretome with ex vivo expansion, age and progressive multiple sclerosis

(2018) Pamela Sarkar et al.   CYTOTHERAPY

Dysregulation of Mesenchymal Stromal Cell Antioxidant Responses in Progressive Multiple Sclerosis

(2018) Juliana Redondo et al.   Stem Cells Translational Medicine

CNS disease diminishes the therapeutic functionality of bone marrow mesenchymal stem cells

(2017) Alex Sargent et al.   EXPERIMENTAL NEUROLOGY

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

(2017) Amelie V. Guitart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

(2017) Juliana Redondo et al.   Multiple Sclerosis Journal

Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes

(2017) Julie Adam et al.   Cell Reports

Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

(2017) Juliana Redondo et al.   Multiple Sclerosis Journal

Nrf2–ARE pathway: An emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

(2016) Izaskun Buendia et al.   PHARMACOLOGY & THERAPEUTICS

Conditioned medium from the stem cells of human dental pulp improves cognitive function in a mouse model of Alzheimer’s disease

(2015) Tsuneyuki Mita et al.   BEHAVIOURAL BRAIN RESEARCH

Bone Marrow Mesenchymal Stromal Cells Isolated from Multiple Sclerosis Patients have Distinct Gene Expression Profile and Decreased Suppressive Function Compared with Healthy Counterparts

(2015) Gislane L. V. De Oliveira et al.   CELL TRANSPLANTATION

High content and high throughput screening to assess the angiogenic and neurogenic actions of mesenchymal stem cells in vitro

(2015) Jennifer J. Bara et al.   EXPERIMENTAL CELL RESEARCH

Reductions in kinesin expression are associated with nitric oxide-induced axonal damage

(2015) Juliana Redondo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Metabolomics Reveals a Key Role for Fumarate in Mediating the Effects of NADPH Oxidase 4 in Diabetic Kidney Disease

(2015) Y.-H. You et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mesenchymal Stem Cell Therapy for Autoimmune Disease: Risks and Rewards

(2015) Hafsa Munir et al.   STEM CELLS AND DEVELOPMENT

Assessment of bone marrow-derived Cellular Therapy in progressive Multiple Sclerosis (ACTiMuS): study protocol for a randomised controlled trial

(2015) Claire M. Rice et al.   Trials

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

Cell-Based Reparative Therapies for Multiple Sclerosis

(2013) Tamir Ben-Hur et al.   Current Neurology and Neuroscience Reports

Hepatocyte growth factor mediates mesenchymal stem cell–induced recovery in multiple sclerosis models

(2012) Lianhua Bai et al.   NATURE NEUROSCIENCE

The emerging role of fumarate as an oncometabolite

(2012) Ming Yang et al.   Frontiers in Oncology

Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway

(2011) Ralf A. Linker et al.   BRAIN

Human bone marrow mesenchymal stem cells protect catecholaminergic and serotonergic neuronal perikarya and transporter function from oxidative stress by the secretion of glial-derived neurotrophic factor

(2011) Alan L. Whone et al.   BRAIN RESEARCH

An Antioxidant Response Phenotype Shared between Hereditary and Sporadic Type 2 Papillary Renal Cell Carcinoma

(2011) Aikseng Ooi et al.   CANCER CELL

Safety and Feasibility of Autologous Bone Marrow Cellular Therapy in Relapsing-Progressive Multiple Sclerosis

(2010) C M Rice et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Characterization of in vitro expanded bone marrow-derived mesenchymal stem cells from patients with multiple sclerosis

(2010) Elizabeth Mallam et al.   Multiple Sclerosis Journal

Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension

(2009) Zhongmin Tian et al.   HYPERTENSION

Mesenchymal stem cell-secreted superoxide dismutase promotes cerebellar neuronal survival

(2009) Kevin Kemp et al.   JOURNAL OF NEUROCHEMISTRY

Human bone marrow-derived mesenchymal stem cells secrete brain-derived neurotrophic factor which promotes neuronal survival in vitro

(2009) Alastair Wilkins et al.   Stem Cell Research

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

(2008) Bruce D. Trapp et al.   Annual Review of Neuroscience

Differences in mesenchymal stem cell cytokine profiles between MS patients and healthy donors: Implication for assessment of disease activity and treatment

(2008) Benedetta Mazzanti et al.   JOURNAL OF NEUROIMMUNOLOGY

Efficacy and safety of oral fumarate in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

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