mTOR signaling in renal ion transport

Cellular mechanism of action of forsythiaside for the treatment of diabetic kidney disease

(2023) Chunmei Xu et al.   Frontiers in Pharmacology

Selective Deletion of the Mechanistic Target of Rapamycin From the Renal Collecting Duct Principal Cell in Mice Down-Regulates the Epithelial Sodium Channel

(2022) Bruce Chen et al.   Frontiers in Physiology

Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration

(2022) Satoshi Shimada et al.   HYPERTENSION

Non-canonical mTORC1 signaling at the lysosome

(2022) Gennaro Napolitano et al.   TRENDS IN CELL BIOLOGY

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

(2022) Peter Gollwitzer et al.   NATURE CELL BIOLOGY

Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition

(2022) Gianluca Figlia et al.   NATURE CELL BIOLOGY

WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport

(2022) Bidisha Saha et al.   JOURNAL OF CELL SCIENCE

Empagliflozin in Patients with Chronic Kidney Disease

(2022)   NEW ENGLAND JOURNAL OF MEDICINE

A Comprehensive Map of mRNAs and Their Isoforms across All 14 Renal Tubule Segments of Mouse

(2021) Lihe Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Genetic and drug-induced hypomagnesemia: different cause, same mechanism

(2021) Willem Bosman et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Hydrogen peroxide (H2O2) mediated activation of mTORC2 increases intracellular Na+ concentration in the renal medullary thick ascending limb of Henle

(2021) Nadezhda N. Zheleznova et al.   Scientific Reports

Amino Acid-Mediated Intracellular Ca2+ Rise Modulates mTORC1 by Regulating the TSC2-Rheb Axis through Ca2+/Calmodulin

(2021) Yuna Amemiya et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Distinct Mitochondrial Pathologies Caused by Mutations of the Proximal Tubular Enzymes EHHADH and GATM

(2021) Anna-Lena Forst et al.   Frontiers in Physiology

How Many Cell Types Are in the Kidney and What Do They Do?

(2021) Michael S. Balzer et al.   Annual Review of Physiology

mTOR-Activating Mutations in RRAGD Are Causative for Kidney Tubulopathy and Cardiomyopathy

(2021) Karl P. Schlingmann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Gitelman-Like Syndrome Caused by Pathogenic Variants in mtDNA

(2021) Daan Viering et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Insights into Salt Handling and Blood Pressure

(2021) David H. Ellison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sodium–Glucose Cotransporter 2 Inhibitors Work as a “Regulator” of Autophagic Activity in Overnutrition Diseases

(2021) Kazuhiko Fukushima et al.   Frontiers in Pharmacology

Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis

(2020) Qingmiao Lu et al.   Cell Death & Disease

Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney

(2020) Gijs A. C. Franken et al.   Acta Physiologica

SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition

(2020) Issei Tomita et al.   Cell Metabolism

NOX4/H 2 O 2 /mTORC1 Pathway in Salt-Induced Hypertension and Kidney Injury

(2020) Vikash Kumar et al.   HYPERTENSION

Regulation of mTORC2 Signaling

(2020) Wenxiang Fu et al.   Genes

Stimulatory effect of insulin on H+-ATPase in the proximal tubule via the Akt/mTORC2 pathway

(2020) M. Nakamura et al.   Physiology International

Insulin promotes sodium transport but suppresses gluconeogenesis via distinct cellular pathways in human and rat renal proximal tubules

(2019) Motonobu Nakamura et al.   KIDNEY INTERNATIONAL

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

(2019) Madhanagopal Anandapadamanaban et al.   SCIENCE

Structural basis for the docking of mTORC1 on the lysosomal surface

(2019) Kacper B. Rogala et al.   SCIENCE

Quantification of molecular heterogeneity in kidney tissue by targeted proteomics

(2018) K. Johanna R. Hoyer et al.   Journal of Proteomics

Therapeutic Suppression of mTOR (Mammalian Target of Rapamycin) Signaling Prevents and Reverses Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive Rats

(2018) Vikash Kumar et al.   HYPERTENSION

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Inhibition of Mammalian Target of Rapamycin Complex 1 Attenuates Salt-Induced Hypertension and Kidney Injury in Dahl Salt-Sensitive RatsNovelty and Significance

(2017) Vikash Kumar et al.   HYPERTENSION

Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis

(2017) Ao Li et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Metabolic injury-induced NLRP3 inflammasome activation dampens phospholipid degradation

(2017) Elena Rampanelli et al.   Scientific Reports

Rag GTPase in amino acid signaling

(2016) Joungmok Kim et al.   AMINO ACIDS

mTORC2 critically regulates renal potassium handling

(2016) Florian Grahammer et al.   JOURNAL OF CLINICAL INVESTIGATION

Altered mTOR signalling in nephropathic cystinosis

(2016) Ekaterina A. Ivanova et al.   JOURNAL OF INHERITED METABOLIC DISEASE

mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells

(2016) Florian Grahammer et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of the transcription factor EB rescues lysosomal abnormalities in cystinotic kidney cells

(2016) Laura R. Rega et al.   KIDNEY INTERNATIONAL

Roles of mTOR complexes in the kidney: implications for renal disease and transplantation

(2016) Daniel Fantus et al.   Nature Reviews Nephrology

Evidence of the Importance of Nox4 in Production of Hypertension in Dahl Salt-Sensitive Rats

(2015) Allen W. Cowley et al.   HYPERTENSION

Cystinosin is a Component of the Vacuolar H+-ATPase-Ragulator-Rag Complex Controlling Mammalian Target of Rapamycin Complex 1 Signaling

(2015) Z. Andrzejewska et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex

(2015) P. Liu et al.   Cancer Discovery

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

(2015) Guang Yang et al.   Cell Reports

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

(2014) Ruzica Bago et al.   BIOCHEMICAL JOURNAL

mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity

(2014) Catherine E. Gleason et al.   JOURNAL OF CLINICAL INVESTIGATION

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

(2014) Jianzhong Li et al.   KIDNEY INTERNATIONAL

Translational research in ADPKD: lessons from animal models

(2014) Hester Happé et al.   Nature Reviews Nephrology

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Insulin increases the functional activity of the renal NaCl cotransporter

(2013) María Chávez-Canales et al.   JOURNAL OF HYPERTENSION

Activation of mTORC1 in Collecting Ducts Causes Hyperkalemia

(2013) Z. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of OSR1 and the sodium, potassium, two chloride cotransporter by convergent signals

(2013) S. Sengupta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses

(2013) Carol Dangelmaier et al.   THROMBOSIS AND HAEMOSTASIS

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Characterization of a novel phosphorylation site in the sodium-chloride cotransporter, NCC

(2012) L. L. Rosenbaek et al.   JOURNAL OF PHYSIOLOGY-LONDON

Delayed mTOR Inhibition with Low Dose of Everolimus Reduces TGFβ Expression, Attenuates Proteinuria and Renal Damage in the Renal Mass Reduction Model

(2012) Melania Kurdián et al.   PLoS One

Sirolimus Induced Phosphaturia is Not Caused by Inhibition of Renal Apical Sodium Phosphate Cotransporters

(2012) Maria Haller et al.   PLoS One

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

(2012) A. V. Nair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

(2012) A. Roczniak-Ferguson et al.   Science Signaling

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

(2011) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Cysteamine therapy delays the progression of nephropathic cystinosis in late adolescents and adults

(2011) Albane Brodin-Sartorius et al.   KIDNEY INTERNATIONAL

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

(2011) R. Zoncu et al.   SCIENCE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Genomic-Derived Markers for Early Detection of Calcineurin Inhibitor Immunosuppressant–Mediated Nephrotoxicity

(2011) Yuxia Cui et al.   TOXICOLOGICAL SCIENCES

Molecular Advances in Autosomal Dominant Polycystic Kidney Disease

(2010) Anna Rachel Gallagher et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Decrease in transient receptor potential melastatin 6 mRNA stability caused by rapamycin in renal tubular epithelial cells

(2010) Akira Ikari et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

mTOR Complex-2 Activates ENaC by Phosphorylating SGK1

(2010) M. Lu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirolimus Therapy to Halt the Progression of ADPKD

(2010) N. Perico et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Primary cilia regulate mTORC1 activity and cell size through Lkb1

(2010) Christopher Boehlke et al.   NATURE CELL BIOLOGY

Rapamycin-induced phosphaturia

(2010) D. S. Kempe et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mechanisms of Nephronophthisis and Related Ciliopathies

(2010) Toby W. Hurd et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative phosphoproteomic analysis reveals cAMP/vasopressin-dependent signaling pathways in native renal thick ascending limb cells

(2010) R. Gunaratne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The mTOR pathway is highly activated in diabetic nephropathy and rapamycin has a strong therapeutic potential

(2009) Hiroyuki Mori et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Advances in the pathogenesis and treatment of polycystic kidney disease

(2009) Vishal Patel et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Polycystin-1 Regulates Extracellular Signal-Regulated Kinase-Dependent Phosphorylation of Tuberin To Control Cell Size through mTOR and Its Downstream Effectors S6K and 4EBP1

(2009) G. Distefano et al.   MOLECULAR AND CELLULAR BIOLOGY

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases

(2008) J. Ponce-Coria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE