WNK1 is a chloride-stimulated scaffold that regulates mTORC2 activity and ion transport

Regulation of distal tubule sodium transport: mechanisms and roles in homeostasis and pathophysiology

(2022) David Pearce et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Hypertension

(2021) Meena S. Madhur et al.   CIRCULATION RESEARCH

NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl – concentration

(2021) Mariángeles Clauzure et al.   IMMUNOLOGY

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

(2021) Lindsey Mayes-Hopfinger et al.   Nature Communications

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters

(2020) Adrián Rafael Murillo-de-Ozores et al.   Frontiers in Physiology

Regulation of mTORC2 Signaling

(2020) Wenxiang Fu et al.   Genes

WNK4 kinase is a physiological intracellular chloride sensor

(2019) Jen-Chi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation at distinct subcellular locations underlies specificity in mTORC2 activation of SGK1 and Akt

(2019) Catherine E. Gleason et al.   JOURNAL OF CELL SCIENCE

ENaC-mediated sodium influx exacerbates NLRP3-dependent inflammation in cystic fibrosis

(2019) Thomas Scambler et al.   eLife

Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis

(2018) Joan Sanchez-Gurmaches et al.   Cell Metabolism

mTORC2 critically regulates renal potassium handling

(2016) Florian Grahammer et al.   JOURNAL OF CLINICAL INVESTIGATION

Extracellular K+rapidly controls NaCl cotransporter phosphorylation in the native distal convoluted tubule by Cl−-dependent and independent mechanisms

(2016) David Penton et al.   JOURNAL OF PHYSIOLOGY-LONDON

Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis

(2016) Andrew S. Terker et al.   KIDNEY INTERNATIONAL

Small-molecule WNK inhibition regulates cardiovascular and renal function

(2016) Ken Yamada et al.   Nature Chemical Biology

Intracellular chloride concentration of the mouse vomeronasal neuron

(2015) SangSeong Kim et al.   BMC NEUROSCIENCE

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride

(2015) Andrew S. Terker et al.   Cell Metabolism

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity

(2014) Catherine E. Gleason et al.   JOURNAL OF CLINICAL INVESTIGATION

A Genetically-Encoded YFP Sensor with Enhanced Chloride Sensitivity, Photostability and Reduced pH Interference Demonstrates Augmented Transmembrane Chloride Movement by Gerbil Prestin (SLC26a5)

(2014) Sheng Zhong et al.   PLoS One

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice

(2013) Mads V. Sorensen et al.   KIDNEY INTERNATIONAL

mTORC2 targets AGC kinases through Sin1-dependent recruitment

(2011) Angus J. M. Cameron et al.   BIOCHEMICAL JOURNAL

mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel

(2011) Ming Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum and Glucocorticoid-induced Kinase (SGK) 1 and the Epithelial Sodium Channel Are Regulated by Multiple with No Lysine (WNK) Family Members

(2010) Charles J. Heise et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Complex-2 Activates ENaC by Phosphorylating SGK1

(2010) M. Lu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of ROMK Channel and K+Homeostasis by Kidney-specific WNK1 Kinase

(2009) Zhen Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL