Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis

Effect of Sirolimus on Disease Progression in Patients with Autosomal Dominant Polycystic Kidney Disease and CKD Stages 3b-4

(2016) P. Ruggenenti et al.   Clinical Journal of the American Society of Nephrology

Prevalence of autosomal dominant polycystic kidney disease in the European Union

(2016) Cynthia J. Willey et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

mTORC1-mediated inhibition of polycystin-1 expression drives renal cyst formation in tuberous sclerosis complex

(2016) Monika Pema et al.   Nature Communications

Inherited renal cystic diseases

(2016) Bohyun Kim et al.   Abdominal Radiology

Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

(2016) Linda S. Steelman et al.   Aging-US

Autosomal Dominant Polycystic Kidney Disease and Intracranial Aneurysms: Is There an Increased Risk of Treatment?

(2015) M.N. Rozenfeld et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Human Polycystin-2 Transgene Dose-Dependently Rescues ADPKD Phenotypes in Pkd2 Mutant Mice

(2015) Ao Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner

(2015) Vladimir G. Gainullin et al.   JOURNAL OF CLINICAL INVESTIGATION

A polycystin-centric view of cyst formation and disease: the polycystins revisited

(2015) Albert C.M. Ong et al.   KIDNEY INTERNATIONAL

Autosomal dominant polycystic kidney disease: the changing face of clinical management

(2015) Albert C M Ong et al.   LANCET

The history and future of targeting cyclin-dependent kinases in cancer therapy

(2015) Uzma Asghar et al.   NATURE REVIEWS DRUG DISCOVERY

Vascular complications in autosomal dominant polycystic kidney disease

(2015) Ronald D. Perrone et al.   Nature Reviews Nephrology

Systems biology of polycystic kidney disease: a critical review

(2015) Luis Fernando Menezes et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Low-Dose Rapamycin (Sirolimus) Effects in Autosomal Dominant Polycystic Kidney Disease: An Open-Label Randomized Controlled Pilot Study

(2014) W. E. Braun et al.   Clinical Journal of the American Society of Nephrology

Altered trafficking and stability of polycystins underlie polycystic kidney disease

(2014) Yiqiang Cai et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease

(2014) Peter C. Harris et al.   JOURNAL OF CLINICAL INVESTIGATION

Scattered Deletion of PKD1 in Kidneys Causes a Cystic Snowball Effect and Recapitulates Polycystic Kidney Disease

(2014) W. N. Leonhard et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An mTOR kinase inhibitor slows disease progression in a rat model of polycystic kidney disease

(2014) K. Ravichandran et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Cyst formation following disruption of intracellular calcium signaling

(2014) Ivana Y. Kuo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polycystin-1: a master regulator of intersecting cystic pathways

(2014) Sorin V. Fedeles et al.   TRENDS IN MOLECULAR MEDICINE

Cdks, cyclins and CKIs: roles beyond cell cycle regulation

(2013) S. Lim et al.   DEVELOPMENT

Sirtuin 1 inhibition delays cyst formation in autosomal-dominant polycystic kidney disease

(2013) Xia Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

A Pkd1-Fbn1 Genetic Interaction Implicates TGF-  Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease

(2013) D. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Polycystin-1 and polycystin-2—it's complicated

(2013) Terry J. Watnick et al.   Nature Reviews Nephrology

Inhibition of Comt with tolcapone slows progression of polycystic kidney disease in the more severely affected PKD/Mhm (cy/+) substrain of the Hannover Sprague-Dawley rat

(2013) Susanne N.E. Boehn et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Long-Term Treatment with Mammalian Target of Rapamycin Inhibitor Does Not Benefit Patients with Autosomal Dominant Polycystic Kidney Disease: A Meta-Analysis

(2013) Cheng Xue et al.   NEPHRON CLINICAL PRACTICE

The Role of Translation Initiation Regulation in Haematopoiesis

(2012) Godfrey Grech et al.   COMPARATIVE AND FUNCTIONAL GENOMICS

Folate-Conjugated Rapamycin Slows Progression of Polycystic Kidney Disease

(2012) J. M. Shillingford et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dose-Dependent Effects of Sirolimus on mTOR Signaling and Polycystic Kidney Disease

(2012) Z. Novalic et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapamycin-mediated suppression of renal cyst expansion in del34Pkd1−/−mutant mouse embryos: An investigation of the feasibility of renal cyst prevention in the foetus

(2012) CHERIE STAYNER et al.   NEPHROLOGY

Rapamycin for treatment of type I autosomal dominant polycystic kidney disease (RAPYD-study): a randomized, controlled study

(2012) G. Stallone et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Sirolimus Produced S-Shaped Effect on Adult Polycystic Kidneys After 2-Year Treatment

(2012) A. Soliman et al.   TRANSPLANTATION PROCEEDINGS

Transcription network and cyclin/CDKs: The yin and yang of cell cycle oscillators

(2011) Laura A. Simmons Kovacs et al.   CELL CYCLE

Molecular Advances in Autosomal Dominant Polycystic Kidney Disease

(2010) Anna Rachel Gallagher et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Polycystic kidney disease: Pathogenesis and potential therapies

(2010) Vinita Takiar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

(2010) J. M. Shillingford et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirolimus Therapy to Halt the Progression of ADPKD

(2010) N. Perico et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sirolimus attenuates disease progression in an orthologous mouse model of human autosomal dominant polycystic kidney disease

(2010) Iram Zafar et al.   KIDNEY INTERNATIONAL

Imaging for the prognosis of autosomal dominant polycystic kidney disease

(2010) Kyongtae T. Bae et al.   Nature Reviews Nephrology

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Everolimus in Patients with Autosomal Dominant Polycystic Kidney Disease

(2010) Gerd Walz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Screening for Intracranial Aneurysm in 355 Patients With Autosomal-Dominant Polycystic Kidney Disease

(2010) H.W. Xu et al.   STROKE

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice

(2009) Carlo Spirli et al.   HEPATOLOGY

Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates  -Catenin

(2009) I. Kim et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Autosomal dominant polycystic kidney disease: the last 3 years

(2009) Vicente E. Torres et al.   KIDNEY INTERNATIONAL

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Gender and human chronic renal disease

(2008) Sharon Silbiger et al.   Gender Medicine

The tuberous sclerosis proteins regulate formation of the primary cilium via a rapamycin-insensitive and polycystin 1-independent pathway

(2008) Tiffiney R. Hartman et al.   HUMAN MOLECULAR GENETICS

Global control of cell-cycle transcription by coupled CDK and network oscillators

(2008) David A. Orlando et al.   NATURE