Brain-enriched RagB isoforms regulate the dynamics of mTORC1 activity through GATOR1 inhibition

Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism

(2022) Shawn B. Egri et al.   MOLECULAR CELL

A Rag GTPase dimer code defines the regulation of mTORC1 by amino acids

(2022) Peter Gollwitzer et al.   NATURE CELL BIOLOGY

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Visualizing and interpreting cancer genomics data via the Xena platform

(2020) Mary J. Goldman et al.   NATURE BIOTECHNOLOGY

Nasally delivered VEGFD mimetics mitigate stroke-induced dendrite loss and brain damage

(2020) Daniela Mauceri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Developmental and epileptic encephalopathy due to SZT2 genomic variants: Emerging features of a syndromic condition

(2020) Marina Trivisano et al.   EPILEPSY & BEHAVIOR

A substrate-specific mTORC1 pathway underlies Birt–Hogg–Dubé syndrome

(2020) Gennaro Napolitano et al.   NATURE

The pseudoGTPase group of pseudoenzymes

(2020) Amy L. Stiegler et al.   FEBS Journal

Arg78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases

(2019) Kuang Shen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Onset of differentiation is post-transcriptionally controlled in adult neural stem cells

(2019) Avni Baser et al.   NATURE

CHOPCHOP v3: expanding the CRISPR web toolbox beyond genome editing

(2019) Kornel Labun et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex

(2019) Kuang Shen et al.   CELL

Mutational inactivation of mTORC1 repressor gene DEPDC5 in human gastrointestinal stromal tumors

(2019) Yuzhi Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Architecture of human Rag GTPase heterodimers and their complex with mTORC1

(2019) Madhanagopal Anandapadamanaban et al.   SCIENCE

Structural basis for the docking of mTORC1 on the lysosomal surface

(2019) Kacper B. Rogala et al.   SCIENCE

Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex

(2019) Rosalie E. Lawrence et al.   SCIENCE

Histone deacetylase 4 shapes neuronal morphology via a mechanism involving regulation of expression of vascular endothelial growth factor D

(2018) Christian Litke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids

(2018) Jin Meng et al.   JOURNAL OF CELL BIOLOGY

Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes

(2018) Kuang Shen et al.   NATURE

A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase–Ragulator lysosomal scaffold

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

SZT2 mutation in a boy with intellectual disability, seizures and autistic features

(2018) Ariana Kariminejad et al.   European Journal of Medical Genetics

mTOR as a central hub of nutrient signalling and cell growth

(2018) Joungmok Kim et al.   NATURE CELL BIOLOGY

Myelination and mTOR

(2017) Gianluca Figlia et al.   GLIA

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

(2017) Kuang Shen et al.   MOLECULAR CELL

Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex

(2017) Ming-Yuan Su et al.   MOLECULAR CELL

SZT2 dictates GATOR control of mTORC1 signalling

(2017) Min Peng et al.   NATURE

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

(2017) Rachel L. Wolfson et al.   NATURE

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

(2017) Mariana E. G. de Araujo et al.   SCIENCE

Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

(2017) Monther Abu-Remaileh et al.   SCIENCE

SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway

(2017) Xin Gu et al.   SCIENCE

The Complex Roles of Mechanistic Target of Rapamycin in Adipocytes and Beyond

(2017) Peter L. Lee et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

(2017) Mee-Sup Yoon   Frontiers in Physiology

The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway

(2016) Lynne Chantranupong et al.   CELL

GATOR1 complex: the common genetic actor in focal epilepsies

(2016) Sara Baldassari et al.   JOURNAL OF MEDICAL GENETICS

The fetal brain sparing response to hypoxia: physiological mechanisms

(2016) Dino A. Giussani   JOURNAL OF PHYSIOLOGY-LONDON

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

The role of mTOR signalling in neurogenesis, insights from tuberous sclerosis complex

(2016) Andrew R. Tee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Novel homozygous mutation inKPTNgene causing a familial intellectual disability-macrocephaly syndrome

(2015) Sander Pajusalu et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma

(2015) Jessica Okosun et al.   NATURE GENETICS

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

(2014) Alejo Efeyan et al.   DEVELOPMENTAL CELL

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells

(2014) Nils A Kulak et al.   NATURE METHODS

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Biallelic SZT2 Mutations Cause Infantile Encephalopathy with Epilepsy and Dysmorphic Corpus Callosum

(2013) Lina Basel-Vanagaite et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in KPTN Cause Macrocephaly, Neurodevelopmental Delay, and Seizures

(2013) Emma L. Baple et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes

(2013) Jose A. Martina et al.   JOURNAL OF CELL BIOLOGY

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

An Amino Acid Deletion in SZT2 in a Family with Non-Syndromic Intellectual Disability

(2013) Michelle Falcone et al.   PLoS One

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

(2012) Malgorzata Urbanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nuclear Calcium-VEGFD Signaling Controls Maintenance of Dendrite Arborization Necessary for Memory Formation

(2011) Daniela Mauceri et al.   NEURON

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE